Histopathological spectrum of polymorphous low-grade adenocarcinoma

Surya, Varun; Tupkari, Jagdish Vishnu; Joy, Tabita; Verma, Priyanka

doi:10.4103/0973-029x.164555

Cited by 7 publications

(3 citation statements)

References 9 publications

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“… 3 Most commonly it presents in the sixth or seventh decade of life with a 2:1 predilection for females. 4 High rates of perineural invasion have been reported. 5 The 10-year relative survival is 98.8%, and complete surgical resection is the preferred treatment of choice.…”

Section: Discussionmentioning

confidence: 99%

Polymorphous low-grade adenocarcinoma with cavernous sinus involvement presenting as third nerve palsy

Chan

Chang

Jiun

et al. 2022

American Journal of Ophthalmology Case Reports

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Section: Discussionmentioning

confidence: 99%

Polymorphous low-grade adenocarcinoma with cavernous sinus involvement presenting as third nerve palsy

Chan

Chang

Jiun

et al. 2022

American Journal of Ophthalmology Case Reports

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“…Hence surgical excision was performed without radiation therapy. Histological reports of PLGA may show several variations such as solid, trabecular, ductal, tubular, cribriform, cystic and papillary cystic patterns, but the infiltrating cells and the cytological features remain more or less the same [10,11]. This was considered while reviewing the histological picture.…”

Section: Discussionmentioning

confidence: 99%

Mistaken identity of polymorphous low‐grade adenocarcinoma treated as periapical lesion in anterior maxilla: A case report

Sridharan¹,

Shashidara²,

Ramya³

et al. 2022

Aust Endodontic J

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This report presents a rare case of polymorphous low‐grade adenocarcinoma (PLGA) in the anterior maxilla, mimicking a periapical lesion. A 56‐year‐old male reported with a painless swelling in the maxillary right canine‐premolar region. The patient gave a history of root canal therapy for the same teeth one month ago. On intraoral examination, the involved teeth were restored with ceramic crowns. Radiographic examination revealed inadequate obturation with an ill‐defined radiolucency in the periapical region. 3D cone beam computer tomography (CBCT) revealed erosion of the buccal cortical plate near the apices of the roots. Endodontic re‐treatment was performed on both the teeth. Following this, the lesion was excised and submitted for histopathological analysis wherein it was identified as PLGA. Computerised tomographic (CT) scan and positron emission tomography scan (PET) results showed no regional or distant metastasis. Under general anaesthesia, the teeth were extracted, and wide surgical excision of the anterior maxilla was done till the healthy bone was exposed. Healing was uneventful during the follow‐up period.

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“…When compared to adenoid cystic carcinoma, staining is positive for p-53, ki-67, bcl-2, and CD117. Perineural invasion is a feature of both PAC and adenoid cystic carcinoma, but the presence of the targetoid arrangement of perineural invasion is characteristic of PAC [ 17 ]. Also, in comparison to PAC, the cells of adenoid cystic carcinoma are smaller with hyperchromatic and angulated nuclei, less cytoplasm, and a coarser nuclear chromatin [ 18 ].…”

Section: Discussionmentioning

confidence: 99%

Polymorphous Adenocarcinoma: A Rare Case Report with Unique Radiographic Appearance on CBCT

Chandra

Ahmed

Koul

et al. 2021

Case Reports in Dentistry

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Background. Polymorphous low-grade adenocarcinoma (PLGA) is a slow growing malignant tumor of minor salivary glands and is generally of indolent nature. However, according to the most recent WHO Classification of Salivary Gland Tumors (2017), the cancer is classified as Polymorphous AdenoCarcinoma (PAC). PAC presents as a less aggressive tumor, though it could on rare occasions demonstrate distant metastasis. Case Presentation. A 47-year-old man who was referred by a private practitioner for a CBCT scan in reference to a proliferative soft-tissue growth in the hard palate. The growth was mild and tender and there was Grade III mobility in relation to all the maxillary teeth. Panoramic radiograph taken previously had revealed evidence of alveolar bone loss in relation to the maxillary teeth and was inconclusive of any other findings. The CBCT scan revealed evidence of moth-eaten appearance of maxilla with destruction of medial and lateral walls and floor of maxillary sinus. There was also evidence of involvement of right eustachian tube, ethmoidal wall, and nasopalatine canal. An intraosseous malignancy of the palate was suspected, and a total maxillectomy was performed. The tissue sample was sent for histopathological assessment wherein changes diagnostic for polymorphous low-grade adenocarcinoma of the palate were observed. Conclusion. PAC is a distinct, yet commonly occurring, minor salivary gland tumor with varied clinical and histologic appearance. This case report highlights the importance of CBCT in diagnosing the intraosseous involvement of such tumors which can help shed some light in enhancing our knowledge about the minor salivary gland malignancies like PAC.

show abstract

Histopathological spectrum of polymorphous low-grade adenocarcinoma

Cited by 7 publications

References 9 publications

Polymorphous low-grade adenocarcinoma with cavernous sinus involvement presenting as third nerve palsy

Polymorphous low-grade adenocarcinoma with cavernous sinus involvement presenting as third nerve palsy

Mistaken identity of polymorphous low‐grade adenocarcinoma treated as periapical lesion in anterior maxilla: A case report

Polymorphous Adenocarcinoma: A Rare Case Report with Unique Radiographic Appearance on CBCT

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