Histopathological spectrum of neoplastic lesions of female reproductive system-a two-year experience in Eastern Nepal

Abstract

Background: Neoplastic lesions of female reproductive system (FRS) consist majority of surgical cases. The aim of this study is to find out the frequency distribution of tumors occurring in FRS.Methods: This is a retrospective study carried out in Birat Medical College, situated in eastern Nepal. All formalin fixed surgical specimen of FRS from August 2015 to September 2017 were subjected for histopathology and examined under light microscopy. All neoplastic lesions were included, and non-neoplastic lesions were excluded from the study.Results: A total number of ninety (90) histopathological tissues representating various types of neoplastic lesion of FRS were studied. Out of which 6 (6.6%) tumors were from uterine cervix, (including 1 cervical leiomyoma and 5 squamous cell carcinoma cervix) 45(50%) tumors were from uterine body, (all leiomyoma) 20 (22.2%) tumors were from ovary (including 9 mature teratoma, 1 immature teratoma, 6 mucinous cystadenoma and 4 cases of serous cystadenoma) and 19 (21.2%) tumors were from breast (including 16 fibroadenoma, 1 lactational adenoma, 2 infiltrating ductal carcinoma and 1 comedo carcinoma). Majority 81(90%) were benign and 9 (10%) were malignant. Most common benign tumor was leiomyoma of uterine body and most common malignant tumor was squamous cell carcinoma of uterine cervix both commonly occurring in the age group of 41-50 years.Conclusions: Benign tumor, leiomyoma is the common tumor occurring in FRS. Carcinoma of the cervix is the common malignant tumor.

Incidence of neoplastic lesions of female genital tract in a tertiary care centre: A 3 year retrospective study

“…Similar observations were also noted in the study by Khandekar S et al (6.28%) [15] while other studies by Gaikwad SL et al [12] , Singh M et al et al [16] and Paul SN et al [13] reported squamous cell carcinoma as 9.28%,7.04% and 7% respectively. In our study, the other histological variant of cervical carcinoma reported was a single case of small cell carcinoma in the age group of 41-50 years.…”

“…Similarly, Dhakal HP et al [17] also noted various other less common histological types of cervical carcinomas out of all the cervical cancers (1293 cases) in their study namely adenocarcinoma (3.8%), small cell carcinoma (0.3%), adenosquamous carcinoma (0.2%) and carcinosarcoma (0.2%) whereas in a study by Rahman MA et al [18] , cervical adenocarcinoma (1.08%) out of 62 cases of gynecological cancers, was also found other than squamous cell carcinoma. [12] Khandekar S [15] Singh M et al [16] Paul S N et al [13] Cervix (squamous cell carcinoma) 5.51% 9.28% 6.28% 7.04% 7% Endometrium (adenocarcinoma) 4.82% 2.14% 3.38% --Ovary (mucinous cystadenocarcinoma) 0.68% 0.71% 0.96% --…”