Histopathological spectrum of gallstone disease from cholecystectomy specimen in rural areas of West Bengal, India- an approach of association between gallstone disease and gallbladder carcinoma

The Spectrum of Gallbladder Histopathology at a Tertiary Hospital in a Developing Country: A Retrospective Study

“…In our study, cholesterolosis was observed in 32.8% of the cases. A study conducted by Mondal et al concluded the presence of the pathology in merely 2.9% of the patient population, while Sangwan et al reported a prevalence of 9.43% [5,19]. The prevalence of the pathology in our study was therefore noted to be significantly higher.…”

“…Imperatively, most of the patients who presented with these premalignant afflictions belonged to the older age groups. This indicates that an increased age at presentation increases the risk of a malignant transformation [ 5 , 15 ]. If not detected early, these lesions can orchestrate the pathogenesis that underlies the development of GBC.…”

“…While carcinoma of the GB remains a relatively rare aetiology, ubiquitous conditions, such as chronic cholecystitis secondary to gallstones, can irritate the GB mucosa, thereby heralding the onset of metaplastic and dysplastic transformations. These transformations can, in turn, predispose the patients to the future development of gallbladder carcinoma (GBC) [4,5]. Timely cholecystectomy to treat such longstanding inflammatory conditions therefore remains focal.…”

“…Pertinently, dilatory detection of GB cancer can lead to adverse outcomes for the patient [8]. Even in instances where it is detected early, GBC boasts a forbidding mortality rate [5,8,9]. To prevent these grave complications, histopathological workup of resected specimens is warranted in order to thwart the pathogenesis underlying GBC.…”

Can gallbladder wall thickness by gross examination predicts its carcinoma before histopathological study?

“…Comparison of incidence of gallbladder carcinoma in the present study with other studies: Incidence of carcinoma gallbladder found in the present study was 1.89% (6 cases), which correlated very well to the incidence found in the study conducted by Murmu S et al [10] (2 cases, 1.88%), Kumar H et al [11] (North Indian data-8 cases, 2%, South Indian data-5 cases, 1.25%) and the study by Kumari G et al [12] (7 cases, 1.27%). A lower incidence was observed in studies done by Beena D et al [13] (1 case, 0.5%), Mondal B et al [14] (5 cases, 0.6%), Sharma I et al [15] (3 cases, 0.86%) and H Mohan et al [16] (12 cases, 1.09%).…”