Histopathological, Lymphoscintigraphical, and Immunological Changes in the Inguinal Lymph Nodes of Rhesus Monkeys during the Early Course of Infection withBrugia malayi

Dennis, Vida A.; Lasater, Barbara L.; Blanchard, James; Lowrie, Robert C.; Campeau, Richard J.

doi:10.1006/expr.1998.4300

Cited by 17 publications

(10 citation statements)

References 15 publications

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“…Rhesus monkeys are permissive to infection (65,66). However, susceptibility to microfilaremia is highly variable (66,67).…”

Section: Brugia Malayimentioning

confidence: 99%

“…Patency generally commences 10 to 12 weeks after subcutaneous injection of L3 larvae but may occur as late as 39 weeks p.i. (66,67). As many as half of infected monkeys remain microfilaremic at 1 year p.i.…”

Section: Brugia Malayimentioning

confidence: 99%

Section: Brugia Malayimentioning

confidence: 99%

“…Infected animals commonly exhibit disruption of lymphatic flow, dependent edema, and grossly enlarged lymph nodes (66)(67)(68). Microscopically, there is evidence of hyperplasia and eosinophilic lymphadenitis (67). Similar to humans, rhesus monkeys that develop lymphedema tend to be amicrofilaremic and exhibit strong immune responses to filarial antigens (68).…”

Section: Brugia Malayimentioning

confidence: 99%

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A Comprehensive, Model-Based Review of Vaccine and Repeat Infection Trials for Filariasis

et al. 2013

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SUMMARY Filarial worms cause highly morbid diseases such as elephantiasis and river blindness. Since the 1940s, researchers have conducted vaccine trials in 27 different animal models of filariasis. Although no vaccine trial in a permissive model of filariasis has provided sterilizing immunity, great strides have been made toward developing vaccines that could block transmission, decrease pathological sequelae, or decrease susceptibility to infection. In this review, we have organized, to the best of our ability, all published filaria vaccine trials and reviewed them in the context of the animal models used. Additionally, we provide information on the life cycle, disease phenotype, concomitant immunity, and natural immunity during primary and secondary infections for 24 different filaria models.

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“…Rhesus monkeys are permissive to infection (65,66). However, susceptibility to microfilaremia is highly variable (66,67).…”

Section: Brugia Malayimentioning

confidence: 99%

Section: Brugia Malayimentioning

confidence: 99%

Section: Brugia Malayimentioning

confidence: 99%

Section: Brugia Malayimentioning

confidence: 99%

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A Comprehensive, Model-Based Review of Vaccine and Repeat Infection Trials for Filariasis

et al. 2013

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“…These findings have been bolstered by the studies in persmissive animal models [e.g. jirds (28), cats (29), dogs (30), monkeys (31) and chimpanzees (32)] in which most of these features have been seen early in infection. With the onset of patency (development of adult worms and/or appearance of microfilariae in the blood), certain immune responses are profoundly altered.…”

Section: Introductionmentioning

confidence: 99%

Regulation of the immune response in lymphatic filariasis: perspectives on acute and chronic infection with Wuchereria bancrofti in South India

Nutman

Kumaraswami

2001

Parasite Immunology

101

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Delineating the immune responses in lymphatic filariasis has been complicated not only by the rapidly expanding knowledge of new immunological mediators and effortors, but also by new methodologies (in particular, circulating filarial antigen detection) for defining and categorizing filarial-infected individuals. By using assays for circulating antigen in the sera collected as part of the many immunological studies performed on individuals in a Wuchereria bancrofti-endemic region of South India, we have attempted to explore the influence of patency on the antigen-driven proliferative and cytokine responses seen in peripheral blood mononuclear cells of individuals with varying clinical manifestations of lymphatic filarial infection. Moreover, we have provided perspectives on the differences between acute and chronic infection with W. bancrofti and suggested mechanisms that may underly the modulation of the immune response as patency occurs.

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Antifilarial Vaccine Development: Present and Future Approaches

Lustigman

Abraham

Klei

2012

Parasitic Helminths

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Histopathological, Lymphoscintigraphical, and Immunological Changes in the Inguinal Lymph Nodes of Rhesus Monkeys during the Early Course of Infection withBrugia malayi

Cited by 17 publications

References 15 publications

A Comprehensive, Model-Based Review of Vaccine and Repeat Infection Trials for Filariasis

A Comprehensive, Model-Based Review of Vaccine and Repeat Infection Trials for Filariasis

Regulation of the immune response in lymphatic filariasis: perspectives on acute and chronic infection with Wuchereria bancrofti in South India

Antifilarial Vaccine Development: Present and Future Approaches

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