Histopathological frequency of feline hepatobiliary disease in the UK

Bayton, W. A.; Westgarth, C.; Scase, T.; Price, David J.; Bexfield, Nick

doi:10.1111/jsap.12810

Cited by 16 publications

(39 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Early descriptions of neutrophilic cholangitis/cholangiohepatitis reported it as a syndrome of aged cats,12 whereas lymphocytic cholangitis was typically found in younger cats,13 a similar pattern was observed by Hirose et al 5 Other studies found the opposite distribution, and described lymphocytic cholangitis as a disease of older cats, and neutrophilic cholangitis as one of middle-aged and younger cats 1 4. The current study, similar to Bayton et al ’s4 study, found cats with neutrophilic cholangitis to be younger than those with lymphocytic cholangitis and this warrants further investigation. One confounding factor in this and other studies is the failure to distinguish between acute and chronic neutrophilic cholangitis which Callahan Clark et al 1 described as having significantly different ages of onset.…”

Section: Discussionsupporting

confidence: 88%

“…Although reversible hepatocellular injury was reported in a number of cases, hepatic lipidosis was only reported in a minority of individuals. These results are similar to the findings in a population of UK cats where biliary and parenchymal disorders made up the majority of submissions 4. However, in the UK population of cats, neutrophilic cholangitis was the most frequent hepatobiliary disease comprising 20.5 per cent of all cases whereas lymphocytic cholangitis only comprised 6.8 per cent 4.…”

Section: Discussionsupporting

confidence: 87%

See 1 more Smart Citation

Retrospective study of the relative frequency of feline hepatobiliary disease in New Zealand based on 10 years of hepatic biopsy samples

Hardcastle¹,

Smith

Gear

2019

Veterinary Record Open

View full text Add to dashboard Cite

AimsTo retrospectively determine the relative frequency of feline hepatobiliary diseases from biopsy specimens submitted to a single laboratory across a 10-year period and to establish whether age, sex or breed associations exist.MethodsHistopathological data from 154 liver biopsies of New Zealand cats sampled between 2008 and 2018 were analysed. The samples were allocated to primary, secondary and tertiary disease categories using criteria established by the World Small Animal Veterinary Association. Breed associations were derived using ORs and 95% CIs. Gender and age associations were also evaluated.ResultsThe most frequently diagnosed hepatobiliary diseases were lymphocytic cholangitis (20 per cent), hepatitis (16.9 per cent), reversible hepatocellular injury (16.4 per cent), neutrophilic cholangitis (9.7 per cent), haematopoietic neoplasia (9.7 per cent), hepatocellular neoplasia (5.6 per cent) and cholangiocellular neoplasia (4.1 per cent). Burmese cats were found to be at significantly increased risk of both biliary and parenchymal diseases and Birman cats to be at significantly increased risk of parenchymal disease. Domestic longhair cats were at significantly increased risk of hepatobiliary neoplasia. Birman cats were at significantly increased risk of hepatitis while domestic shorthair cats were at significantly decreased risk of neutrophilic cholangitis, reversible hepatocellular injury and hepatitis.ConclusionsThis study is the first retrospective examination of the relative frequency of hepatobiliary disease in biopsy specimens from New Zealand cats. Some breeds were associated with specific histopathology.

show abstract

Section: Discussionsupporting

confidence: 88%

Section: Discussionsupporting

confidence: 87%

Retrospective study of the relative frequency of feline hepatobiliary disease in New Zealand based on 10 years of hepatic biopsy samples

Hardcastle¹,

Smith

Gear

2019

Veterinary Record Open

View full text Add to dashboard Cite

show abstract

“…Primary hepatic neoplasia is estimated to account for 1% to 2.9% of all cancers [15,16]. Biliary carcinomas and HCC have been reported at a frequency of 17% and 27% of all feline hepatic neoplasms [6]. In our collections from the USA and UK over the past 10 years, HCC was the most common hepatic primary epithelial cancer (HCC = 71/132, 54%).…”

Section: Discussionmentioning

confidence: 92%

“…The potential impact of DCH on feline health will be of great interest to the global veterinary community because of the popularity of cats as human companion animals [14]. Chronic hepatitis is apparently uncommon in cats, being reported to occur at a frequency of 2.4% of all feline hepatic biopsies [6]. Primary hepatic neoplasia is estimated to account for 1% to 2.9% of all cancers [15,16].…”

Section: Discussionmentioning

confidence: 99%

“…Elevations in viral load and serum alanine aminotransferase (ALT), biomarkers of HBV progression, in some DCH-infected cats provide indirect support for a possible role for DCH in feline liver disease [5]. Chronic hepatitis and HCC, potential sequelae of HBV infection in humans, also occur in domestic cats, but they have been considered to be idiopathic in this species [6]. In this international, multicenter study, we used PCR and in situ hybridization (ISH) to identify hepatotropism, the cellular targets, and the distribution of DCH in normal and diseased feline liver samples.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

A Novel Hepadnavirus is Associated with Chronic Hepatitis and Hepatocellular Carcinoma in Cats

Pesavento

Jackson

Scase³

et al. 2019

Viruses

View full text Add to dashboard Cite

In 2015, over 850,000 people died from chronic hepatitis and hepatocellular carcinoma (HCC) caused by hepatitis B virus (HBV). A novel hepatitis B-like virus has recently been identified in domestic cats. The pathogenic potential of domestic cat hepadnavirus (DCH), for which 6.5% to 10.8% of pet cats are viremic, is unknown. We evaluated stored formalin-fixed, paraffin-embedded biopsies of diseased and normal feline liver for the presence of DCH using PCR and in situ hybridization (ISH). DCH was detected in 43% (6/14) of chronic hepatitis cases and 28% (8/29) of HCCs, whereas cholangitis (n = 6), biliary carcinoma (n = 18) and normal liver (n = 15) all tested negative for DCH. Furthermore, in DCH-associated cases, the histologic features of inflammation and neoplasia, and the viral distribution on ISH were strikingly similar to those seen with HBV-associated disease. Several histological features common in human HBV-associated hepatitis, including piecemeal necrosis and apoptotic bodies, were identified in DCH-positive cases of chronic hepatitis. In two cases of HCC examined, the proliferation index in regions that were ISH-positive was higher than in ISH-negative regions. The intracellular distribution of virus in both hepatitis and HCC demonstrated that viral nucleic acid is present in both nuclear and cytoplasmic forms. Collectively, these findings demonstrate a compelling association between DCH and some cases of chronic hepatitis and hepatocellular carcinoma in the cat that mirrors features of HBV-associated hepatopathies. Future investigations of viral epidemiology and natural history are needed to establish the impact of DCH on feline health.

show abstract