Histopathological findings in eyes after silicone oil injection

Kirchhof, Bernd; U, Tavakolian; Paulmann, H.; Heimann, Klaus

doi:10.1007/bf02144130

Cited by 59 publications

(35 citation statements)

References 4 publications

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“…29 30 In the retinectomy oil specimens, intraretinal silicone oil was observed only when the retinal architecture was severely disorganised, suggesting that retinal injury is a prerequisite for oil infiltration. Kirchof et al, 31 in a case series of eight eyes, reported that intraretinal silicone oil was absent unless accompanied by subretinal oil. In addition, animal studies did not find silicone oil in the outer retinal layer unless injected subretinally, 32 and it has been postulated that this may be because of the integrity of the outer limiting membrane.…”

Section: Discussionmentioning

confidence: 98%

Immunopathology of intraocular silicone oil: retina and epiretinal membranes

Wickham

Asaria

Luthert³

et al. 2007

British Journal of Ophthalmology

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Section: Discussionmentioning

confidence: 98%

Immunopathology of intraocular silicone oil: retina and epiretinal membranes

Wickham

Asaria

Luthert³

et al. 2007

British Journal of Ophthalmology

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“…Bambas et al [14] found toxic low-molecular-weight components in SiO samples removed from eyes after several months. Several studies showed oil droplets in epiretinal membranes, retina, and optic nerve [32][33][34][35][36][37][38] . In our study, we could not find clear signs of retained SiO within retinal tissue.…”

Section: Discussionmentioning

confidence: 99%

Thinning of Inner Retinal Layers after Vitrectomy with Silicone Oil versus Gas Endotamponade in Eyes with Macula-Off Retinal Detachment

Purtskhvanidze¹,

Hillenkamp²,

Tode³

et al. 2017

Ophthalmologica

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Purpose: To evaluate retinal layer thickness with optical coherence tomography (OCT) in eyes with macula-off retinal detachment after silicone oil (SiO) or gas endotamponade. Procedures: Cross-sectional study of 40 eyes with macula-off rhegmatogenous retinal detachment that underwent vitrectomy. 20 eyes received SiO tamponade and 20 matched eyes received gas. 33 healthy fellow eyes served as controls. Macular spectral domain OCT was performed with automated layer detection in the 5 inner subfields of the Early Treatment Diabetic Retinopathy Study (ETDRS) map. Results: Comparing the SiO group with the gas group, the ganglion cell layer showed a significant thinning in all fields of the inner ring of the ETDRS map, the inner plexiform layer in the nasal, superior and temporal quadrants, and the outer plexiform layer in the nasal quadrant. Conclusions: Inner retinal layers in the fovea/parafovea were significantly thinner in the SiO group. Prospective studies are warranted to further elucidate possible retinal adverse effects of SiO tamponade.

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“…24,25 Silicone oils also have other disadvantages, including increased postoperative cataract formation and glaucoma development and the need for surgical removal. [26][27][28][29][30][31] Additionally, silicone oil is hydrophobic, so it is not possible to completely fill the vitreous cavity with it. As a result, a fluidic space is created where growth factors can accumulate and proliferative membranes can form.…”

Section: Discussionmentioning

confidence: 99%

A Self-Assembling Peptide Gel as a Vitreous Substitute: A Rabbit Study

Uesugi

Sakaguchi

Hayashida

et al. 2017

Invest. Ophthalmol. Vis. Sci.

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Citation: Uesugi K, Sakaguchi H, Hayashida Y, et al. A self-assembling peptide gel as a vitreous substitute: a rabbit study. Invest Ophthalmol Vis Sci. 2017;58:4068-4075. DOI: 10.1167/iovs.17-21536 PURPOSE. To evaluate a self-assembling peptide gel as a potential vitreous substitute.METHODS. PanaceaGel SPG-178, a self-assembling peptide gel, was diluted with distilled water and a balanced salt solution to achieve a final peptide concentration of 0.1%. The gel's refractive index, visible light transmission rate, and rheologic properties were investigated. The gel's biocompatibility was evaluated by examining the cellular viability (live and dead staining) and proliferation rate (alamarBlue assay). A 25-G pars plana vitrectomy was performed on the right eye of 21 New Zealand white rabbits. The gel was then injected into the vitreous cavity of 15 eyes. Six eyes were injected with a balanced salt solution (BSS) and served as controls. Toxicity was examined using electroretinography and histologic analysis after the injection of the gel.RESULTS. The gel's physical properties closely resembled those of human vitreous. The gel showed no apparent toxicity. When the gel was injected into the vitreous cavity, fragmentation was not observed. Additionally, the gel remained transparent in the vitreous cavity and no complications were observed for 3 months after the injection. Electroretinography and histology confirmed the gel's biocompatibility.CONCLUSIONS. This diluted self-assembling peptide gel could be provide a promising vitreous substitute.Keywords: vitreous humor, retina, self-assembling peptide gel T he vitreous is located in the posterior segment of the eye and fills approximately two-thirds of the globe. It is a waterbased hydrogel containing collagen and hyaluronic acid. It also plays an important role in the pathophysiology for some vitreoretinal diseases, including retinal detachment and macular hole. 1,2To treat these diseases, the vitrectomy is an important procedure, and the use of vitreous substitute is necessary. The aim of its use is to not only provide an organic substitute to recover IOP and eyeball volume but to also supply a functional substitute for retinal reattachment. Air, expandable gas, and silicone are currently used as vitreous substitutes. However, air and expandable gas are not suitable long-term substitutes due to their absorption. A silicone substitute must be removed from the eye after a specific period of time because its toxicity can lead to complications, including glaucoma and cataracts. Because of their hydrophobic properties of these substitutes, the eye is not completely filled and growth factors can accumulate in the unfilled spaces. This may also lead to postoperative complications, including development of proliferative membranes. [4][5][6] Recently, several studies have examined both natural 7-13 and synthetic 2,14-20 hydrophilic polymers as vitreous substitutes. These polymers do not have limitations related to hydrophobicity, but other problems may be observed. Hydrogels ...

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Histopathological findings in eyes after silicone oil injection

Cited by 59 publications

References 4 publications

Immunopathology of intraocular silicone oil: retina and epiretinal membranes

Immunopathology of intraocular silicone oil: retina and epiretinal membranes

Thinning of Inner Retinal Layers after Vitrectomy with Silicone Oil versus Gas Endotamponade in Eyes with Macula-Off Retinal Detachment

A Self-Assembling Peptide Gel as a Vitreous Substitute: A Rabbit Study

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