Histopathological features and their prognostic impact in nodular lymphocyte‐predominant Hodgkin lymphoma – a matched pair analysis from the German Hodgkin Study Group (GHSG)

Hartmann, Sven; Eichenauer, Dennis A.; Plütschow, Annette; Mottok, Anja; Bob, Roshanak; Koch, Karoline; Bernd, Heinz‐Wolfram; Cogliatti, Sergio; Hummel, Michael; Feller, Alfred C.; Ott, German; Möller, Peter; Rosenwald, Andreas; Stein, Harald; Hansmann, Martin‐Leo; Engert, Andreas; Klapper, Wolfram

doi:10.1111/bjh.12997

Cited by 38 publications

(32 citation statements)

References 16 publications

(27 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Atypical nLPHL comprised just over a fifth of our cohort (n = 13; 22%), which is slightly less than in adults with nLPHL in published literature (Hartmann et al, 2014(Hartmann et al, , 2013a as the cohort is relatively small it is possible that in a larger cohort of patients the number of children with atypical nLPHL may be higher. However, this is the first report of histological variants of nLPHL in children and it may be that diagnostic criteria used in the previous studies were different.…”

Section: Discussionmentioning

confidence: 84%

“…The small size of our cohort in this report makes it difficult to draw conclusions about the prognostic significance of immunoglobulin isotype expression in nLPHL although it is reported to have some significance in B‐cell NHL (Lindemalm et al , ). A recent report on histological features and their prognostic impact, including expression of IgD, on outcome in adult patients with nLPHL revealed a non‐significant trend towards a lower relapse rate in patients whose presenting lymph node contained epithelioid cell clusters (Hartmann et al , ).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Childhood and Adolescent nodular lymphocyte predominant Hodgkin lymphoma ‐ A review of clinical outcome based on the histological variants

et al. 2015

View full text Add to dashboard Cite

SummaryNodular lymphocyte predominant Hodgkin lymphoma (nLPHL) comprises approximately 10-12% of all childhood Hodgkin lymphoma. As the majority have low stage disease recent years have seen a de-escalation of treatment intensity to avoid treatment-related morbidity. This report evaluates treatment outcome in children with histopathological variants of nLPHL after therapy de-escalation. Biopsies from 60 patients were reviewed and histology categorized as typical (n = 47; 78%) or variant nLPHL (n = 13; 22%). Furthermore, presence of immunoglobulin D (IgD) expression by the lymphocyte predominant (LP) cells was assessed in 41 patients. Treatment outcomes were compared according to treatment received and histopathology of nLPHL. Compared to typical nLPHL, children with variant nLPHL had higher stage disease at diagnosis (stage III: 3/13; 23% vs. 3/47; 6%, P = 0Á11), lower complete response rates (6/13; 46% vs. 38/47; 81%, P = 0Á029) and higher relapse rates (2/13; 15% vs. 2/47; 4%, P = 0Á20). Additionally, IgD expression by LP cells was associated with poorer treatment response and was more commonly seen in patients with variant nLPHL. (11/13; 85% vs. 15/28; 54%, P = 0Á08). Variant histology appears to be indicative of a poorer prognosis in patients with early stage disease, and may be an important factor to take into account when moving towards reduced intensity treatment for nLPHL.

show abstract

Section: Discussionmentioning

confidence: 84%

Section: Discussionmentioning

confidence: 99%

Childhood and Adolescent nodular lymphocyte predominant Hodgkin lymphoma ‐ A review of clinical outcome based on the histological variants

et al. 2015

View full text Add to dashboard Cite

show abstract

“…Immunohistochemical IgD‐staining was performed for a subset of patients using anti‐IgD antibody (IR517, DAKO, Glostrup, Denmark) and the Envision‐FLEX detection system (DAKO) as previously described …”

Section: Methodsmentioning

confidence: 99%

The time to relapse correlates with the histopathological growth pattern in nodular lymphocyte predominant Hodgkin lymphoma

et al. 2019

Self Cite

View full text Add to dashboard Cite

Nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) can present with different histopathological growth patterns. The impact of these histopathological growth patterns on relapse characteristics is unknown. We therefore analyzed paired biopsies obtained at initial diagnosis and relapse from 33 NLPHL patients who had received first‐line treatment within German Hodgkin Study Group (GHSG) trial protocols, and from a second cohort of 41 relapsed NLPHL patients who had been treated outside GHSG studies. Among the 33 GHSG patients, 21 patients presented with a typical growth pattern at initial diagnosis, whereas 12 patients had a variant histology. The histopathological growth patterns at initial diagnosis and at relapse were consistent in 67% of cases. A variant histology at initial diagnosis was associated with a shorter median time to lymphoma recurrence (2.8 vs 5.2 years; P = .0219). A similar tendency towards a shorter median time to lymphoma recurrence was observed for patients presenting with a variant histology at relapse, irrespective of the growth pattern at initial diagnosis. Results obtained from the 41 NLPHL patients who had been treated outside GHSG studies were comparable (median time to lymphoma recurrence for variant histology vs typical growth pattern at initial diagnosis: 1.5 vs 7.0 years). In conclusion, the histopathological growth pattern remains consistent at relapse in the majority of NLPHL cases, and has major impact on the time of relapse.

show abstract

“…Hartman S. et al, performed a matched‐pair analysis to evaluate the prognostic impact of several histopathological features in NLPHL. None of the histopathological features was associated with a particular clinical outcome . A recent analysis of 99 relapsed NLPHL patients, which were obtained from the database of German Hodgkin Study Group (GHSG), has also documented a favorable outcome even after relapsed disease.…”

Section: Discussionmentioning

confidence: 99%

Nodular lymphocyte predominant Hodgkin's lymphoma in daily practice: A multicenter experience

Gemici

Aydoğdu

Terzi

et al. 2017

Hematological Oncology

View full text Add to dashboard Cite

Nodular lymphocyte predominant Hodgkin's lymphoma (NLPHL) is a rare subtype of Hodgkin's lymphoma. In this study, we aimed to investigate the clinical features and therapeutic outcomes of patients with NLPHL who were diagnosed at different institutes in Turkey. We retrospectively reviewed the records of the patients diagnosed with NLPHL. Adult patients who were diagnosed after 2005 with histological confirmation were selected for the study. Forty-three patients were included in the study. Median age of patients was 37.5 years (18-70) at the time of diagnosis. About 60.5% patients were diagnosed as stage I and II NLPHL, and remaining 39.5% had stage III and IV disease. Median follow-up was 46 months. During follow-up, none of the patients died. Seven patients relapsed or progressed after initial therapy at a median of 12 months. Five of 7 relapsed/refractory patients (71.4%) were salvaged with chemotherapy only (DHAP, ICE), and the remaining 2 (28.6%) were salvaged with chemoimmunotherapy. All of relapsed/refractory patients were able to achieve complete remission after salvage therapy. Lactate dehydrogenase levels were significantly higher in patients with progressive disease compared with nonprogressive disease. Our study showed an excellent outcome with all patients alive at last contact with a median follow up of 46 months despite a wide range of different therapeutic approaches. All relapsed and refractory patients were successfully salvaged despite a low frequency of patients received immunotherapy in conjunction with chemotherapy. Our results suggest that immunotherapy may be reserved for further relapses.

show abstract

Histopathological features and their prognostic impact in nodular lymphocyte‐predominant Hodgkin lymphoma – a matched pair analysis from the German Hodgkin Study Group (GHSG)

Cited by 38 publications

References 16 publications

Childhood and Adolescent nodular lymphocyte predominant Hodgkin lymphoma ‐ A review of clinical outcome based on the histological variants

Childhood and Adolescent nodular lymphocyte predominant Hodgkin lymphoma ‐ A review of clinical outcome based on the histological variants

The time to relapse correlates with the histopathological growth pattern in nodular lymphocyte predominant Hodgkin lymphoma

Nodular lymphocyte predominant Hodgkin's lymphoma in daily practice: A multicenter experience

Contact Info

Product

Resources

About