Histopathological evidence of inorganic mercury and methyl mercury toxicity in the arctic charr (Salvelinus alpinus)

Ribeiro, Ciro Alberto de Oliveira; Belger, Lauren; Pelletier, Émilien; Rouleau, Claude

doi:10.1016/s0013-9351(02)00025-7

Cited by 138 publications

(98 citation statements)

References 23 publications

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“…Loss of fat reserve cells was also reported in arctic charr (Salvelinus alpinus) and Northern pike (Esox lucius) exposed to inorganic Hg (Oliveira-Ribeiro et al 2002;Drevnick, Sandheinrich, and Oris 2006). In the current study, there was no evidence of hepatic necrosis in the control or Hg exposure groups, unlike another study in arctic charr associated with Methyl Hg exposure, which showed severe necrosis of hepatocytes (Oliveira-Ribeiro et al 2002). In Hg-exposed bleaks, there were multifocal granulomas, macrovesicular steatosis, nuclear pyknosis of hepatocytes with bile duct proliferation ), but no evidence of these lesions was found in this study.…”

Section: Discussionmentioning

confidence: 60%

Short-term Exposure of Nile Tilapia (Oreochromis niloticus) to Mercury

et al. 2012

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To investigate effects of short-term mercury (Hg) exposure in tilapia (Oreochromis niloticus) including histopathological changes, Hg bioaccumulation, and protective role of metallothionein (MT) in different exposure routes, adult tilapias were intraperitoneally injected, orally intubated, or semistatically exposed to 0.5, 1, 2, 5 mg/g mercuric chloride. Histopathology, autometallography (AMG), inductive coupled plasma-atomic emission spectrometry (ICP-AES), and MT immunohistochemistry were determined at 0, 3, 6, 9, 12, and 15 days postexposure. Microscopic lesions were observed in the kidney, hepatopancreas, spleen, and intestine. AMG positive grains were found in renal tubule epithelium, melanomacrophage centers (MMCs), and intestinal epithelium of treated tilapias. Hg concentrations measured by ICP-AES in abdominal visceral organs were significantly higher than in other organs. All exposure routes caused lesions of increasing severity and Hg accumulations in a dose-dependent manner. Semistatic groups produced the highest intensity of lesions, AMG positive staining, as well as total Hg concentrations. Positive MT expression in renal tubule epithelium, pancreatic acini, and splenic MMCs was observed only in semistatic groups. The semistatic exposure route demonstrated the most significant microscopic lesions, Hg bioaccumulation, and MT expression.

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Section: Discussionmentioning

confidence: 60%

Short-term Exposure of Nile Tilapia (Oreochromis niloticus) to Mercury

et al. 2012

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“…Therefore, the high T-Hg differential from gills to its internal interface (blood) gives support to the idea that gills provide a rapid and significant storage compartment for inorganic mercury. 47 This aspect can assume an augmented significance if we consider the high renewal rate of branchial tissue as an unfavourable factor to bioconcentration; gills' epithelium is regularly subject to exfoliation and erosion, which is counteracted by an intense cell division rate. 48 The tendency of the gills/kidney ratios to be nearer to 1, namely at L2, associated with the significant correlation observed between T-Hg in gills and kidney, corroborates the idea that kidney is preferentially targeted by chemicals when taken up through the gills.…”

Section: Mercury Accumulation Dynamicsmentioning

confidence: 99%

Mercury distribution in key tissues of fish (Liza aurata) inhabiting a contaminated estuary—implications for human and ecosystem health risk assessment

et al. 2009

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This study brings a new viewpoint based on multiple-tissue analyses to form the basis for a predictive mode of mercury accumulation dynamics in fish body under field conditions. Total mercury (T-Hg) was determined in key tissues of Liza aurata captured along an estuarine contamination gradient, displaying the following hierarchy: kidney > liver > muscle > brain > gills > blood. Brain was the tissue that better reflected the mercury contamination extent, closely followed by liver and muscle. Organic mercury (O-Hg) measured in muscle and liver represented more than 85% and less than 30% of the T-Hg, respectively. The lowest O-Hg percentage was found in the most contaminated area, for both muscle and liver. Mercury distribution and accumulation patterns showed dependence on the specific tissue. The high mercury levels found in organs involved in vital physiological processes point out the risk to autochthonous fish fauna. Human risk associated to the ingestion of fish living in the surveyed areas cannot be excluded.

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“…It is thus necessary to investigate the impact of these rainbow trout production technologies on the fish organism, including the morphology of gills, using a histopathological evaluation to explore the health of fish xposed to a variety of factors both under laboratory (Cerquiera and Fernandes 2002, Mazon et al 2002, Oliveira-Ribeiro et al 2002, Thophon et al 2003 and environmental (Teh et al 1997, Stentiford et al 2003, Flores-Lopez et al 2005 conditions. If used for such a purpose, pathomorphology is easier and faster than functional changes and demonstrates abnormalities earlier than the latter Lauren 1990, Strzyżewska et al 2016).…”

Section: Introductionmentioning

confidence: 99%

Impact of production technology on morphological lesions in the gills of commercial rainbow trout (Oncorhynchus mykiss, Walbaum 1792)

Strzyżewska-Worotyńska

Szarek

Babińska

et al. 2017

Polish Journal of Veterinary Sciences

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The most popular rainbow trout (Oncorhynchus mykiss, Walbaum 1792) production technologies include both an extensive method with the flow through system (FTS) and an intensive method with the recirculating aquaculture system (RAS). Their impact on the fish was evaluated with a morphological assessment of the gills, as these are organs susceptible to environmental changes. Trout of 350 -500 g body mass were caught for trial in spring and autumn, with 36 fish originating from 3 fish farms with the FTS system and an equal number from 3 RAS fish farms (n = 6). The fish were macroscopically examined and the gills were investigated microscopically (haematoxylin and eosin staining). Hypertrophy and hyperplasia were most commonly detected, amounting to 89% of all structural abnormalities. These lesions were slightly more common in the FTS, especially in autumn, whereas the changes to the blood vessels in the gills were observed more frequently in the rainbow trout from the RAS system than in the fish obtained from the FTS technology (the difference was statistically significant). The morphological lesions in the mucous cells of the gills were detected at a comparable severity regardless of the technology or production season. The predominantly low values of the histopathologic indices, which described the microscopic lesions in the gills of fish from the FTS and RAS systems, showed that the examined organ was most often free of lesions or demonstrated only minor morphological damage regardless of the production technology.

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Histopathological evidence of inorganic mercury and methyl mercury toxicity in the arctic charr (Salvelinus alpinus)

Cited by 138 publications

References 23 publications

Short-term Exposure of Nile Tilapia (Oreochromis niloticus) to Mercury

Short-term Exposure of Nile Tilapia (Oreochromis niloticus) to Mercury

Mercury distribution in key tissues of fish (Liza aurata) inhabiting a contaminated estuary—implications for human and ecosystem health risk assessment

Impact of production technology on morphological lesions in the gills of commercial rainbow trout (Oncorhynchus mykiss, Walbaum 1792)

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