Histopathological Evaluation of Skin Neoplasms

Abstract

Introduction: Skin tumor incidence has increased over the last several decades. A wide range of tumors are encountered in clinical practice. Accurate identification of skin lesions is vital in ensuring malignancies are not missed and that they are treated early to avoid morbidity and mortality.Materials and Methods: A retrospective cross sectional hospital based study on a series of cases was performed in the Department of Pathology, Patan Academy of Health Sciences, Patan Hospital, Lalitpur, Nepal from April 2011 to March 2016. Data from the histopathology database were analyzed using SPSS version 16.0.Results: During the study period, 410 skin biopsies were received, of which 214 (52.2%) were skin neoplasms. Among them, 175 (81.8%) were benign and 39 (18.2%) were malignant neoplasms. Incidence of keratinocytic tumors was highest followed by soft tissue tumors and melanocytic tumors. Intradermal nevus was the most common benign neoplasm. Among the malignant neoplasms, squamous cell carcinoma was most prevalent (46.1%) followed by basal cell carcinoma (15.3%). Skin neoplasms were present in all age groups with maximum number of benign neoplasms prevalent in 21-30 years and malignant in 51-60 years age group. Mean age was 38 years and 58 years for benign and malignant neoplasms respectively.Conclusions: Histopathological evaluation of skin biopsy is an important tool in diagnosis of skin neoplasms. Intradermal nevus and squamous cell carcinoma was the most common benign and malignant neoplasm respectively. Malignant neoplasms were more common in older patients.

Skin Tumors among Biopsy Samples in Patients Attending Dermatological Out Patient Department in a Tertiary Care Hospital of Nepal: A Descriptive Cross-sectional Study

“…Females also had more benign tumors in various other studies from Nepal. [10][11][12] Similar to our study malignant skin tumors were commoner in females in a study by Adhikari et al 19 This may be due to the fact that females have health seeking behavior for their skin problems as they are more cosmetically concerned compared to males.…”

“…Similar findings were observed in various studies. 10,[11][12] In our study, out of 105 benign tumors, soft tissue tumors of dermis (37.1%) were commonest followed by keratinocytic tumors. Karki et al also showed out of 142 cases of benign tumors, soft tissue tumors of the dermis (34%) were commonest followed by keratinocytic tumors.…”

“…Keratinocytic tumors have been observed to be the commonest skin tumors in Nepal in studies done by Sherpa and KC and Thapa et al also. [11][12] Maximum number of malignant tumors in our study belonged to the keratinocytic category by 90%. Similar findings were observed in various studies.…”

“…1 Similarly, in our study as well out of 125 skin tumors, 84% were benign and 16% were malignant. In the study done by Sherpa and KC 11 , out of 214 skin tumors, 81.8% were benign and 18.2% were malignant. 11 Similar results were obtained from various studies from Nepal.…”

“…In the study done by Sherpa and KC 11 , out of 214 skin tumors, 81.8% were benign and 18.2% were malignant. 11 Similar results were obtained from various studies from Nepal. 10,12 Studies from India also showed higher number of benign tumors.…”