Histopathological Evaluation of Liver Autopsies in a Tertiary Care Hospital: A Case Series

Nibhoria, Sarita; Jhajj, Kanwardeep; Nibhoria, Varinder; Padda, Preeti; Sandhu, Samarjit Kaur

doi:10.5958/j.0973-9130.7.2.012

Cited by 5 publications

(4 citation statements)

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“…Fatty liver was more common in the age group of 51-60 years as reported by Alagarsamy J et al, 4 Patel PR et al 5 and Selvi RT et al 6 But, in the present study, higher number of fatty liver cases were found to be in the age group of 41-50 years (31.14%), followed by 21-30 years (29.50%) of total cases. Our finding is comparable with the finding of Bal MS et al 10 Cirrhosis was found in 14.08% of total cases, which is comparable with Alagarsamy J et al, 4 whereas lower incidence were observed by Selvi RT et al, 6 Nibhoria S et al, 11 Devi PM et al 3 and Bal MS et al 10 recorded higher number of cirrhosis cases in the age group of 41-50 years with the male predominance, which is comparable to our study, whereas Alagarsamy J et al 4 and Selvi RT et al 6 observed cirrhosis mostly in the age group of 51-60 years. High incidence of cirrhosis and fatty liver in younger age group compared to other studies can be explained by indulge into alcohol consumption or higher incidence of viral hepatitis at young age in this area, which has progressed to cirrhosis.…”

Section: Discussionsupporting

confidence: 92%

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Histopathological Patterns of Liver Diseases in Medical Autopsies

Choudhury¹,

Laishram²,

Potom³

2017

jebmh

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BACKGROUND Liver is the site for wide spectrum of diseases, primary as well secondary, which maybe symptomatic or silent and incidentally diagnosed during routine investigation or autopsy examination. The main purpose of our study was to identify different spectrum of histopathological findings of liver in medical autopsies. MATERIALS AND METHODS The study was conducted in the Department of Pathology, Regional Institute of Medical Sciences (RIMS), Imphal. All the consecutive liver specimens dissected out during medical autopsy and postmortem were included in the study. Detailed clinical information including age and sex were obtained. All the liver specimens were examined meticulously and the gross findings were noted down. Histopathological slides were prepared from the representative areas and findings recorded. RESULTS In the present study, a total of 330 liver specimens were examined from medical autopsies during the period of 5 years. Among them, 39 cases were autolysed and remaining 291 cases were analysed grossly and histologically. 249 (85.5%) cases were males and 42 (14.4%) cases were females. 71 (24.39%) cases had no obvious pathology, followed by fatty liver (20.96%), portal triaditis (18.55%), cirrhosis (14.08%), hepatitis (11.34%) and steatohepatitis (5.15%). Other important cases like liver necrosis (2.40%), granulomatous lesion (0.68%), tuberculosis (0.68%), chronic venous congestion (0.68%), malaria pigment (0.34%), leukaemic infiltration (0.34%) and bile duct hamartoma (0.34%). Fatty liver and cirrhosis was found to be most common in the age group of 41-50 years with male predominance. Incidentally, diagnosed liver diseases are not uncommon in medical autopsy. CONCLUSION We concluded that the autopsy examination of liver is very helpful to identify silent liver diseases as it is very common in apparently healthy individuals.This data may be utilised for a medical audit.

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Section: Discussionsupporting

confidence: 92%

“…Selvi RT et al 6 and Nibhoria S et al 11 recorded hepatitis cases as 13.9% and 12.98% respectively, which is found to be similar with our observation (11.34%). In contrary to this, Devi PM et al 3 and Pudale S S et al 8 observed higher incidence of hepatitis in their respective studies.…”

Section: Discussionsupporting

confidence: 91%

Histopathological Patterns of Liver Diseases in Medical Autopsies

Choudhury¹,

Laishram²,

Potom³

2017

jebmh

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“…1,19 Chronic hepatitis is usually due to hepatotropic viruses, or conditions like autoimmune chronic hepatitis or chronic idiosyncratic drug induced hepatitis. 1,[24][25][26][27][28][29][30][31] Our study also showed increased incidence of chronic hepatitis which may be due to associated pre-existing lesions like viral infections.…”

Section: Discussionmentioning

confidence: 81%

Spectrum of morbid anatomy of liver in autopsy cases

et al. 2021

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Background: Purpose of autopsy is to learn the truth about the person’s health during and how the person died. Thus, autopsy study provides valuable information about the disease. The main aim of the study was to know the spectrum of morbid anatomical changes in liver autopsy.Methods: A prospective study was carried out on 100 liver specimens of autopsy cases comprising of 37 cases of roadside accidents, 17 of poisoning, 13 of burns, 10 of chronic illness, 7 each of hanging and head injury, 4 of myocardial infarction and 5 of death due to miscellaneous causes. Representative microsections of liver were evaluated for histopathological parameters like congestion, ballooning degeneration, hepatocellular necrosis, sinusoidal dilation, fatty change, bile stasis, fibrosis, lobular inflammation and portal inflammation.Results: Out of total 100 cases, 77 were males and 23 females. Male to female ratio was 3.34:1. Hepatomegaly was seen in 15% of cases. Chronic venous congestion was the main histopathological diagnosis seen in 61% of the cases followed by chronic hepatitis in 12%, normal liver histology in 9%, hepatic steatosis and cirrhosis in 6%, granulomatous hepatitis in 2%, and sinusoidal congestion, portal triaditis and secondary neoplasm in 1% each.Conclusions: Chronic venous congestion, chronic hepatitis, cirrhosis and hepatic steatosis were the common liver diseases identified. Autopsy study is useful to monitor the cause of death and to plan medical strategy. Histopathological examination of the liver is specialized learning tool to study the various diseases of liver which is a great value in improving the diagnosis.

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“…In the present study triple vessel diseases was 42 cases (46.6%), followed by double vessel diseases in 36 cases (40%) & single vessel disease in 12 cases (13.33%). Though 90 cases of atherosclerotic coronary artery diseases were seen out of 100 cases, frank myocardial infarction [5][6][7] was encountered in only 2 cases. In the present study, healed myocardial infarction taking fibrosis as evidence of old myocardial infarction we got 46% of cases with previous infarcts.…”

Section: Resultsmentioning

confidence: 99%

Study of Histomorphological Findings in Deaths due to Heart Diseases: An Autopsy Based study

Narayan

2023

jiafm

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Cardiovascular diseases remain the biggest cause of death worldwide. More people die annually from cardiovascular diseases then from any other diseases. Autopsies have been diagnostic tool to establish the cause of death & the missed diagnosis, if any, in instances where there have been no clinically identified heart problems. 1 The current study is aimed to establish the morphological & histopathological changes in heart, coronaries & aorta which have contributed to cause of death & also sources as a database for frequency of heart diseases found at autopsy.

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Histopathological Evaluation of Liver Autopsies in a Tertiary Care Hospital: A Case Series

Cited by 5 publications

References 0 publications

Histopathological Patterns of Liver Diseases in Medical Autopsies

Histopathological Patterns of Liver Diseases in Medical Autopsies

Spectrum of morbid anatomy of liver in autopsy cases

Study of Histomorphological Findings in Deaths due to Heart Diseases: An Autopsy Based study

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