2020
DOI: 10.14202/vetworld.2020.1045-1049
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Histopathological evaluation of latex of Bellaco-Caspi, Himatanthus sucuuba (Spruce) Woodson on wound healing effect in BALB/C mice

Abstract: Background and Aim: Himatanthus sucuuba (Spruce) Woodson (Apocynaceae) is a medicinal plant known as "Bellaco- Caspi" widely distributed in Loreto, Peru. In the Peruvian traditional medicine, the latex of the plant is used for the treatment of wounds, inflammation, ulcers, and other ailments. This study aims to evaluate the wound healing effect of the latex of H. sucuuba in BALB/C albino mice. Materials and Methods: Thirty BALB/C male mice were used for wound healing study. In the experimental procedu… Show more

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Cited by 6 publications
(5 citation statements)
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“…As indicated by the histological changes, treatment with latex caused collagen formation and anti-inflammatory effects and closed injuries in less time compared to the control group without treatment. Our results are similar to those in a previous report, but these latter results were derived via 15 days of treatment with once-daily application [ 6 ].…”
Section: Resultssupporting
confidence: 92%
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“…As indicated by the histological changes, treatment with latex caused collagen formation and anti-inflammatory effects and closed injuries in less time compared to the control group without treatment. Our results are similar to those in a previous report, but these latter results were derived via 15 days of treatment with once-daily application [ 6 ].…”
Section: Resultssupporting
confidence: 92%
“…On day 10, mice were euthanized, and tissue cuts of the treated zone were immediately fixed in buffer formol, embedded in paraffin, sliced into sections 4 μm thick, and stained with hematoxylin and eosin (H&E). Finally, the samples were analyzed using an optic microscope (Olympus BX51; Olympus Corporation, Tokyo, Japan) [ 6 ].…”
Section: Methodsmentioning
confidence: 99%
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“…Results of this study suggest that the extract accelerates wound healing by inducing fibroblast migration and, in turn increases collagen production in the affected area. In the initial stages of wound healing, fibroblasts play a fundamental role by migrating to the wound area and inducing synthesis of a new extracellular matrix in fibroplasia and granulation tissue formation [27][28][29]. Important to consider in the proliferation phase is that when collagen has completely filled the wound, the fibroblast activity will stop and this is a physiological process in the human body to prevent excessive wound healing; and under the influence of growth factors and hydrolytic enzymes released by macrophages, fibroblasts proliferate and produce a large amount of collagen [29,30].…”
Section: Discussionmentioning
confidence: 99%
“…In the initial stages of wound healing, fibroblasts play a fundamental role by migrating to the wound area and inducing synthesis of a new extracellular matrix in fibroplasia and granulation tissue formation [27][28][29]. Important to consider in the proliferation phase is that when collagen has completely filled the wound, the fibroblast activity will stop and this is a physiological process in the human body to prevent excessive wound healing; and under the influence of growth factors and hydrolytic enzymes released by macrophages, fibroblasts proliferate and produce a large amount of collagen [29,30]. The amount of collagen fibers deposited in the tissue can be used as a marker of mechanical resistance of connective and epithelial tissue, which form a support structure to promote wound healing and for maintaining tissue strength in the wound area [31]; also reducing the chances of opportunistic infections in the area.…”
Section: Discussionmentioning
confidence: 99%