Histopathological effects of experimental exposure to lead on nervous system in albino female rats

Al-Khafaf, A. I.; Ismail, Hana Kh.; Al-Saidya, A. M.

doi:10.33899/ijvs.2019.126248.1273

Cited by 13 publications

(11 citation statements)

References 21 publications

(31 reference statements)

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“…Synapses that play a significant role in the transmission of nerve signals are strongly linked to neurotoxicity due to oxidative stress (20). Since fluorine has the property of crossing the blood-brain barrier (7), nerve cells are highly susceptible to fluoride damage and neuronal fat and protein oxidation due to their high mitochondrial content, especially the presynaptic nerve cell and this result confirms that boric acid in cells may be an antioxidant agent (6,21).…”

Section: Discussionmentioning

confidence: 63%

Effect of boric acid on sodium fluoride toxicity in chicks

Alabbasi¹,

Alabdaly²

2021

IJVS

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The aim of this study to explore the therapeutic effect of boric acid on the neurobehavioral (motor activity) level, and histopathologic changes in the brain, liver and kidneys against fluorosis. In this study rose chicks have been used and determined medium lethal sodium fluoride dose at 346.5 mg/kg orally. The chicks divided into four random groups each one consists of 10 chicks. The first group considered to be a control group, the second received 20 mg/kg of sodium fluoride, the third group received 10 mg/kg of boric acid and the fourth received 20 mg/kg of sodium fluoride and boric acid at the same previous dosages. After two weeks of daily treatment, neurobehavioral measures were taken, the use of boric acid has a major effect to improve the neurobehavioral measurement and develop complications of ALT, AST, creatinine, Ca, MDA. The results indicate that boric acid may be a therapeutic agent against the fluoride toxicity of the brain, liver and kidney. This result support by histopathological changes which represented by inflammation, congestion of portal vein and dilation of sinusoids in the liver and vacuolation, vasogenic edema and gliosis in the brain and Kidney of showed segmentation of glomeruli, dilation of Bowman's space, necrosis of epithelial cells renal tubules and hemorrhage of NaF group, while the liver of the NaF with boric acid group showed an improvement the results of histopathological examination of the liver, brain and kidneys compared to the NaF group alone. The results revealed that boric acid has a preventing effects against fluoride after two weeks of treatment with boric acid.

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Section: Discussionmentioning

confidence: 63%

Effect of boric acid on sodium fluoride toxicity in chicks

Alabbasi¹,

Alabdaly²

2021

IJVS

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“…Group three treated at dose of 20 ml/ kg/ rat of red bull. The beverage was given daily through oral route via intragastric gavage to all animals of group 2 and 3 for 30 days (10). After completing the experimental period each animal was sacrificed by decapitation.…”

Section: Experimental Designmentioning

confidence: 99%

Histopathological changes in kidney and pancreas induced by energy drinks in adult male rats

Qassim¹,

Al-Sammak²,

Ayoob³

2021

IJVS

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The study aims to assess the impact of various doses of red bull on kidney and pancreas of male albino rats. Thirty male albino rats were assigned to three groups (10 animals/ group). Control group 1 received standard diet and water, group 2 and group 3 received daily oral doses of 10 ml/kg/rat and 20 ml/kg/rat of the energy drink (red bull) respectively for 30 days. Under light microscope no tissue changes were seen in kidney and pancreas of control group. In group 2 red bull causes vacuolar degeneration as well as coagulative necrosis of renal tubular epithelium, vascular congestion in the glomeruli and in the interstitial space of the kidney, in addition to atrophy of the glomeruli, as regard to pancreas it causes vascular congestion of the islets of Langerhans, increase in the size of the islets, besides, necrosis of Langerhans cells. In group 3 red bull leads to more atrophic glomeruli, massive coagulative necrosis of renal tubular epithelium, marked vascular dilatation and congestion in the interstitial space and degenerative changes of the renal tubular epithelium, whereas the pancreatic tissue revealed reduction in the size of the islets of Langerhans, vacuolation and degeneration of their cells, necrosis of other islets with mononuclear inflammatory cells infiltration and degenerative changes of pancreatic acini. It is concluded that administration of red bull to rats for 30 days will affect the histological structure of kidney as well as pancreas and this effect is a dose dependent.

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“…Dehydration (by serial dilution of ethyl alcohol), clearing (by xylol), and paraffin embedding of specimens were performed. Parasagittal sections of five microns (μm) were taken for all blocks to be ready for H&E staining (19)(20)(21) to be ready for blinded examination under Bright field Olympus light microscope(Japan)light microscope. The photomicrographs of structural changes were obtained by digital camera attached via plan apochromatic objectives.…”

Section: Study Ending and Histopathological Assessmentmentioning

confidence: 99%

Histological changes of CA and DG regions of hippocampus of rats’ brain after exposure to Acetaminophen in postnatal period

Hussin¹,

Khalel²

2021

IJVS

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Authors reported that exposure to acetaminophen postnatally may be linked to increasing the risk of ASD. However, the reports on its effects on the brain are scanty, and the knowledge concerning their safety is little as there is a traditional left out of the clinical trials by users. The present work tried to elucidate the histological effects of acetaminophen on the hippocampus of neonate male rats after early postnatal exposure. The pups were categorized into2 groups, the control group, and the acetaminophen treated group. The acetaminophen treated animals were injected subcutaneously with acetaminophen of 60 mg/Kg/day from postnatal day (PND) 7 to PND 14, while the control group treated with normal saline with a similar approach. The histopathologic assessment revealed a diminishing in the pyramidal cells layer thickness of Cornue Ammonis. Some areas are devoid of cells with the appearance of Ghost like cells indicating features of neural cell death, degenerated neurons in the pyramidal layer are noticed. Features of nuclear clumping of pyramidal cell layer were shown. Moreover, several changes including vacuolations in the granular layer of DG with disorganization in DG. Neuronal processes presented with clumping. Apoptosis in the granular cells layer and hilus of a section of DG with the appearance of many astrocytes and microglial cells. Exposures to clinically relevant doses of acetaminophen in the postnatal period were shown to affect the histology of rat hippocampal regions, and a balanced risk assessment based on the best professional judgment must be prioritized.

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Histopathological effects of experimental exposure to lead on nervous system in albino female rats

Cited by 13 publications

References 21 publications

Effect of boric acid on sodium fluoride toxicity in chicks

Effect of boric acid on sodium fluoride toxicity in chicks

Histopathological changes in kidney and pancreas induced by energy drinks in adult male rats

Histological changes of CA and DG regions of hippocampus of rats’ brain after exposure to Acetaminophen in postnatal period

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