Histopathological differential diagnosis of frontal fibrosing alopecia and fibrosing alopecia in a pattern distribution

Teixeira, Mónica; Dias, Maria Fernanda Reis Gavazzoni; Vilar, Enoí Aparecida Guedes; Pantaleão, Luciana; Jourdan, R F R; Ekelem, Chloe; Rochael, Mayra C

doi:10.1111/bjd.20592

Cited by 1 publication

(3 citation statements)

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“…This ratio decrease in Chinese FAPD is consistent with that in previous studies. T:V mean ratio score was 3.19 : 1 in Teixeira's study, 8 and 1.8 : 1 in Jerjen's. 13 The histopathology of FAPD typically shows features of both LPP and AGA in each biopsy specimen, including interface dermatitis (vacuolar degeneration of the follicular epithelium and epithelial/stromal clefting of inflamed follicles), concentric perifollicular lamellar fibrosis, follicular scars, and hair follicle miniaturization.…”

Section: Discussionmentioning

confidence: 62%

“…This ratio decrease in Chinese FAPD is consistent with that in previous studies. T:V mean ratio score was 3.19 : 1 in Teixeira's study, 8 and 1.8 : 1 in Jerjen's 13 …”

Section: Discussionmentioning

confidence: 71%

“…Based on the descriptions in previous studies, 2,3,7,8 the following histopathologic information associated with AGA was assessed and collected: (1) the numbers of total hair follicles, terminal follicles (≥0.06 mm in diameter), indeterminant follicles (0.03-0.06 mm in diameter), and vellus/miniaturized follicles (<0.03 mm in diameter) were counted on transverse sections; (2) telogen-to-vellus (T:V) ratio was calculated. Indeterminant follicles were divided by two and added to the 6) follicular spongiosis.…”

Section: Histopathologymentioning

confidence: 99%

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Clinicopathological characteristics of fibrosing alopecia in a pattern distribution: a single‐center, retrospective study

Wei,

Ni,

Huang

et al. 2023

Int J Dermatology

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BackgroundFibrosing alopecia in a pattern distribution (FAPD) is a distinct entity of primary cicatricial alopecia (PCA), mimicking diffuse hair loss of androgenetic alopecia (AGA) with trichoscopic and histopathologic features of both AGA and lichen planopilaris (LPP).MethodsClinical, demographic, and histopathological data of 20 FAPD patients were retrospectively collected.ResultsAll patients presented with female pattern hair loss with a median Sinclair grade of 3. Trichoscopic findings revealed hair diameter variability (20/20), perifollicular erythema (mild 7/20, moderate 11/20, severe 2/20), peripilar casts (none 2/20, mild 12/20, moderate 5/20, severe 1/20), and loss of follicular ostia (+12/20, ±7/20, −1/20). Histopathologic examination revealed perifollicular lymphocytic infiltration at the infundibulum or isthmus level and an increase of vellus‐like hairs. All cases showed interface dermatitis with concentric perifollicular lamellar fibrosis and follicular scars. Infundibular or isthmic infiltration of mast cells was found.ConclusionsThe uniqueness of our study lies in perifollicular mast cells and discovering that the young population is at higher risk than previously thought. Clinicopathological features of FAPD were identified, filling the void of much‐needed details for FAPD diagnosis tailored to the Chinese population.

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Section: Discussionmentioning

confidence: 62%

“…This ratio decrease in Chinese FAPD is consistent with that in previous studies. T:V mean ratio score was 3.19 : 1 in Teixeira's study, 8 and 1.8 : 1 in Jerjen's 13 …”

Section: Discussionmentioning

confidence: 71%