2005
DOI: 10.1097/01.mpa.0000186245.35716.18
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Histopathological Diagnosis of Pancreatic Intraepithelial Neoplasia and Intraductal Papillary-Mucinous Neoplasms: Interobserver Agreement

Abstract: We conclude that the new definitions of PanIN and IPMN improve the consistency in classifying these lesions, but additional work is needed to further improve the reproducibility of their classification.

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Cited by 92 publications
(74 citation statements)
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“…Previous studies have found KRAS mutations, mainly at codon 12 in the exon 1, in 31% to 86 % of IPMNs (47% in our study) [21][22][23][24][25][26]. The wide variety of the reported frequencies most likely is due to the ongoing better definition of these lesions [7,38,39] and might also be dependent on the sensitivity of a chosen screening methodology [40,41]. For this study, we chose to use the plain PCR technique with direct genomic DNA sequencing to keep possible false positive results to a minimum.…”
Section: Discussionmentioning
confidence: 59%
“…Previous studies have found KRAS mutations, mainly at codon 12 in the exon 1, in 31% to 86 % of IPMNs (47% in our study) [21][22][23][24][25][26]. The wide variety of the reported frequencies most likely is due to the ongoing better definition of these lesions [7,38,39] and might also be dependent on the sensitivity of a chosen screening methodology [40,41]. For this study, we chose to use the plain PCR technique with direct genomic DNA sequencing to keep possible false positive results to a minimum.…”
Section: Discussionmentioning
confidence: 59%
“…[1][2][3] Interobserver agreement studies have been introduced as a way to enhance consensus on terminology and classification of lesions. [4][5][6][7][8] The study of pathogenesis and disease outcome would be facilitated by classification system that is devoid of subjective interpretation and could uniformly be applied worldwide, thus enabling clinicians and scientists to share and compare information.…”
mentioning
confidence: 99%
“…The natural history of IPMN is not entirely known [23] . The central type of IPMN is characterized by a higher proportion of malignancies when compared to the peripheral forms of these tumors [24] .…”
Section: Discussionmentioning
confidence: 99%