2012
DOI: 10.1590/s1678-91992012000300005
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Histopathological characterization of experimentally induced cutaneous loxoscelism in rabbits inoculated with Loxosceles similis venom

Abstract: Abstract:Envenomation by Loxosceles bites is characterized by dermonecrotic and/or systemic features that lead to several clinical signs and symptoms called loxoscelism. Dermonecrotic lesions are preceded by thrombosis of the dermal plexus. Recent studies show that atheromatous plaque is prone to thrombosis due to endothelial cell apoptosis. To the best of our knowledge, there are no reports of microscopic dermal lesion and endothelial cell apoptosis induced by Loxosceles similis venom in the literature. Thus,… Show more

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Cited by 3 publications
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“…The dermatohistopathology of Loxosceles bites include dermal edema, thickening of blood vessel endothelium, leukocyte infiltration, intravascular coagulation, vasodilatation, destruction of blood vessel walls and hemorrhage. [ 15 ] Renal injury in loxoscelism has been attributed to pigmentary nephropathy due to hemoglobin or myoglobin, secondary to hemolysis or rhabdomyolysis. [ 16 ]…”
Section: Discussionmentioning
confidence: 99%
“…The dermatohistopathology of Loxosceles bites include dermal edema, thickening of blood vessel endothelium, leukocyte infiltration, intravascular coagulation, vasodilatation, destruction of blood vessel walls and hemorrhage. [ 15 ] Renal injury in loxoscelism has been attributed to pigmentary nephropathy due to hemoglobin or myoglobin, secondary to hemolysis or rhabdomyolysis. [ 16 ]…”
Section: Discussionmentioning
confidence: 99%