Histopathological Changes of Joint Capsule and Articular Cartilage after Knee Joint Immobility for Two Weeks in Rats.

Takemura, Keiju; Hoso, Masahiro; Yoshikubo, Hiroaki; Inoue, Sumito; Kanemori, Yoshiko; Tachino, Katsuhiko

doi:10.1589/rika.16.71

Cited by 7 publications

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“…to those observed in the short immobilization period and may be attributable to the fact that the decline in metabolism observed with aging was similar to the changes in the metabolic environment following immobilization. Regarding the change in elastic fibers, Takemura et al 12) reported decreased elastic fibers following immobilization based on the findings of a study, in which the knee joint of a rat was fixed for 2 weeks and then histologically examined. Our study is supportive of theirs since a similar tendency was observed, though no significant difference was found.…”

Section: We Histopathologically Evaluated Changes In the K N E E J O mentioning

confidence: 99%

Histopathological Changes of Joint Capsule after Joint Immobility Compared with Aging in Rats

et al. 2010

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Abstract. [Purpose] We examined the histopathological changes in the joint capsule that occurred due to long-term immobilization of the joint, and compared them with those seen in aged rats.[Subjects] A total of 26 male Wistar rats were used in this study.[Methods] The right knee joints of the experimental group rats were immobilized for periods of 2, 4, 8, 16, or 32 weeks, and three 13-week-old "adult" rats and three 70-week-old "aged" rats were used as control groups. At the end of each immobilization period, the right knee joints of the rats were used as samples for histological examination.[Results] We observed histopathological changes in the joint capsules occurring due to joint immobilization. Increase in the thickness of the joint capsule had occurred by 4 weeks of immobilization and developed with prolongation of the immobilization period. An increase in the thickness was also observed in the joint capsule of aged rats. Further, the areas of elastic fibers in aged rats and those immobilized for 32 weeks were decreased compared to adult rats.[Conclusion] The joint capsules after immobility and aging showed similar changes, suggesting that some kind of identical mechanism causes the two conditions.

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Section: We Histopathologically Evaluated Changes In the K N E E J O mentioning

confidence: 99%

Histopathological Changes of Joint Capsule after Joint Immobility Compared with Aging in Rats

et al. 2010

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“…Akenson et al 19) used a biochemical approach and reported that the amount of extracellular matrix (i.e., water and glycosaminoglycan) decreased in connective tissues around the immobilized knee joint of rabbits, leading to less spacing between collagen fibers, and our histological findings corroborated this. The posterior joint capsule became more dense after 2 weeks of immobilization 20) , and the whole joint capsule became thicker 18) , indicating a quantitative change in addition to a qualitative change. After joint excision, collagen fiber bundles could move against each other more easily, and the spaces between them expanded, resulting in a decreased density of the bundles in both the treatment and non-treatment groups.…”

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confidence: 96%

Histopathological Changes in Joint Components in a Rat Knee Joint Contracture Model Following Mobilization

et al. 2012

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Abstract.[Purpose] The aim of this study was to investigate the histopathological effects of mobilization on joint components using a rat knee joint contracture model. [Method] Twenty-two male Wistar rats (aged 9 weeks) were randomly divided into an experimental group (n = 18) and a control group (n = 4). The experimental group had the right posterior limb knee joint immobilized for 8 weeks to induce contracture after which this group was subdivided into three subgroups-immobilized, treatment, and non-treatment groups. In the immobilized group (n = 6), knee joint specimens were collected immediately after immobilization. The non-treatment group (n = 6) was bred normally for 8 weeks, while the treatment group (n = 6) underwent mobilization during the same 8 weeks. After breeding, we prepared tissue specimens of the knee joint for observation in the sagittal plane and examined them using a light microscope. [Results] Compared to the non-treatment group, the treatment group showed an increase in the number of fat cells in the synovial subintima and a reduction in the density of collagen fiber bundles in the posterior joint capsule.[Conclusion] Joint mobilization appears to effectively improve joint function.

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Histopathological Changes in Joint Components during Contracture-A Study of the Long Term Knee Joint Immobility Model in the Rat-

Watanabe

Hoso

Takemura³

et al. 2007

Rigakuryoho kagaku

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Histopathological Changes of Joint Capsule and Articular Cartilage after Knee Joint Immobility for Two Weeks in Rats.

Cited by 7 publications

References 2 publications

Histopathological Changes of Joint Capsule after Joint Immobility Compared with Aging in Rats

Histopathological Changes of Joint Capsule after Joint Immobility Compared with Aging in Rats

Histopathological Changes in Joint Components in a Rat Knee Joint Contracture Model Following Mobilization

Histopathological Changes in Joint Components during Contracture-A Study of the Long Term Knee Joint Immobility Model in the Rat-

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