Histopathological changes of experimental burns in rabbits treated with Berberine nano gel

Abstract

Berberin, isolated from Coscinium fenestratum and some plants in the family Ranunculaceae, has been shown to have healing effects on wounds, burns. Study to determine the effect of treatment of superficial burns in rabbits on the pathophysiology of burns of berberine nano gel produced by the National Burn Hospital.The study was conducted on 45 rabbits, creating circular burns with a diameter of 4cm on both sides of the rabbit's back skin; rabbits were divided into 3 groups (15 rabbits, 30 burns/group), study group (A): Treated site by Berberin nano gel; control group (B): Treatment with SSD; Standard group (C): Treatment with Natri Chloride 0.9%. Follow-up histopathology at the rabbit burn site until the end of the study. Results: Group A burns had a lower number of inflammatory cells and a higher number of fibroblasts and blood vessels than group B and C burns. Conclusion: Berberin nano gel for treatment of superficial burns has been shown to have anti-inflammatory effects and stimulate wound healing.