Histopathological changes in tumor budding between biopsy and resected specimens from patients treated with preoperative S‐1 chemotherapy for oral cancer

Abstract

Background S‐1 is an oral anticancer agent containing tegafur, a prodrug of 5‐fluorouracil (5‐FU). Preoperative S‐1 chemotherapy is performed to prevent tumor proliferation before surgery in oral squamous cell carcinoma (OSCC). The aim of this study was to evaluate the effects of preoperative S‐1 chemotherapy on tumor budding. Methods We examined 248 cases of OSCC and evaluated the budding scores in biopsy and resected specimens by keratin immunohistochemistry. Results In S‐1‐untreated patients, the budding scores in resected specimens tended to show a mild increase. S‐1 treatment had the effect of lowering the budding score, although some cases with dramatically increased budding scores in resected specimens were found in the early phase of administration. Relapse‐free survival showed a significant difference (P < .01) according to the presence or absence of S‐1 treatment among patients with high budding scores. Conclusions The present findings indicate that S‐1 administration may be more effective in patients with high budding scores than in those with lower budding scores.

Oral cancer: changing the aim of the biopsy in the age of precision medicine. A review

“…All six papers included were retrospective, and were divided into two groups based on the aim of the study (Tab. II) 48,49,[58][59][60][61] :…”

“…Comparison of tissue markers on biopsy and post-operative samples. Three papers [58][59][60] compared the values of biomarkers measured on patient's biopsy and post-operative samples from the same patients in order to evaluate their concordance and reliability. Almangush et al 58 reviewed the slides of 100 patients (81 = Stage I-II) with SCC of the mobile tongue treated with surgical excision.…”

“…III) and LVI, and found that the depth of infiltration measured on biopsies was lower than that on post-operative samples, while there was a good correlation of budding score in pre-treatment and post-treatment samples. Seki Soda et al 60 recently analysed the relationship between TBS in biopsies and in resected specimens of 248 patients with OSCC and the effect of pre-operative chemotherapy on TBS. The authors did not report staging, but pointed out that 141 of 248 patients received preoperative chemotherapy.…”

The Emerging Impact of Tumor Budding in Oral Squamous Cell Carcinoma: Main Issues and Clinical Relevance of a New Prognostic Marker

“…Manual detection [ 15 , 18 , 19 , 24 , 25 , 26 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 36 , 37 , 38 , 40 , 43 , 53 , 54 , 55 , 56 , 57 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 ]…”

“…Single cut-off: 3 buds/field [ 31 , 32 , 44 , 64 ] 4 buds/field [ 55 ] 5 buds/fields [ 16 , 23 , 24 , 26 , 29 , 33 , 34 , 37 , 38 , 40 , 43 , 53 , 58 , 59 , 60 , 63 , 64 , 67 , 69 , 71 ] 10 buds/field [ 15 , 19 , 61 , 62 ] 15 buds/field [ 24 ] …”