Histopathological changes in the pancreas of laboratory rats

Kendrey, G; Roe, F. J. C.

doi:10.1258/002367769781071844

Cited by 34 publications

(4 citation statements)

References 10 publications

(6 reference statements)

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“…It is perhaps significant that one of the 12 control rats had a pancreatic lesion identical to that found in the ethanol-intoxicated animals. Kendrey and Roe (1969) described similar lesions in chronic pancreatitis occurring spontaneously in the rat, and Wexler (1970) in repeatedly bred male and female rats. Limited acinoductal lesions occur in normal man also, and it may be that the role of alcohol is to aggravate or unmask lesions which usually remain latent (Sarles et al, 1965).…”

Section: Chronic Ethanol Intoxicationmentioning

confidence: 76%

A comparison of alcoholic pancreatitis in rat and man

Sarles¹,

Lebreuil²,

Tasso³

et al. 1971

Gut

132

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SUMMARY Acute ethanol intoxication was studied in 38 Wistar rats, 18 on a balanced dietand 20 on a high fat diet, fed by gavage on 47 % ethanol in a dosage of from 3 to 12 g/kg body weight daily for periods ranging from three to 16 days. No macroscopic changes in pancreas or liver were found in any of these animals. Histological changes (venous congestion of the pancreas, the liver, and the kidneys) were found in rats given 4 g or more per kilogram. The only difference between the findings in rats given a balanced diet and those given a high fat diet was the development of fatty livers in the latter group.Chronic ethanol intoxication was studied in 45 Wistar rats, on a balanced diet, which were given 20% ethanol freely for 20 to 30 months. More than half the animals developed pancreatic lesions very similar to those of human chronic pancreatitis. The pathological changes, in foci surrounded by normal pancreatic tissue, were a reduction in acini, duct multiplication (probably by neogenesis), protein plugs, sometimes calcified in the ducts and sclerosis. Samples of pancreatic juice from four animals exposed to ethanol contained significantly higher protein concentrations than samples taken from two control animals. Protein precipitates appeared spontaneously in the pancreatic juice of the animals exposed to ethanol, but not in that of the controls. These findings are very similar to those in alcoholic pancreatitis in man, which has thus been reproduced for the first time in experimental animals. Beta-cell adenomata of the islets of Langerhans were observed in four of the rats exposed to ethanol.

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Section: Chronic Ethanol Intoxicationmentioning

confidence: 76%

A comparison of alcoholic pancreatitis in rat and man

Sarles¹,

Lebreuil²,

Tasso³

et al. 1971

Gut

132

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“…The ductal plugs observed in ethanol-fed rats have also been reported in control animals [34], and have occurred spontaneously in 15-17 months old Wistar rats [12,35].…”

Section: Chronic Alcohol Feeding Alonementioning

confidence: 80%

Animal Models in Alcoholic Pancreatitis — What Can We Learn?

2002

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“…McMinn and Kugler (15) and Kendrey and Roe (11) performed a histochemical investigation of pancreatic duct epithelial cells in mammalian species (the mouse, hamster, rat, guinea pig, cat, dog, and rhesus monkey). The pancreatic duct epithelia revealed specialized cells, different in different species (35).…”

Section: Resultsmentioning

confidence: 99%

Morphological study of the pancreatic duct system in chinchilla (Chinchilla laniger Molina).

KUCHINKA,

RADZIMIRSKA,

NOWAK

et al. 2024

Medycyna Weterynaryjna

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The aim of our investigation was analysis of the morphology of the pancreatic duct system in chinchilla. Investigation was carried out on twenty adult individuals of either sex. Macromorphological studies of pancreatic duct system were performed using colored latex. The histological studies were performed paraffin slides with H&E staining method. Photography documentations were prepared using a Nikon Digital Sight SD-L1 System. The pancreas in this species is formed of three irregular flattened parts or lobes. The main accessory duct was not observed. The accessory pancreatic duct was the only duct to drain pancreatic secretion into the duodenum on the minor duodenal papilla. The histological structure of these ducts does not differ from the general scheme. Our investigation demonstrated significant anatomical variability of the pancreatic duct system in chinchilla which is not always accurately described in literature.

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Histopathological changes in the pancreas of laboratory rats

Cited by 34 publications

References 10 publications

A comparison of alcoholic pancreatitis in rat and man

A comparison of alcoholic pancreatitis in rat and man

Animal Models in Alcoholic Pancreatitis — What Can We Learn?

Morphological study of the pancreatic duct system in chinchilla (Chinchilla laniger Molina).

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