Histopathological changes in the anterior segment with anterior and posterior chamber intraocular lens

Mastromonaco, Christina; Balazsi, Matthew; Saheb, Nabil; Salimi, Ali; Burnier, Miguel N.

doi:10.1016/j.jcjo.2020.05.002

Cited by 3 publications

(2 citation statements)

References 34 publications

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“…Recent histologic studies comparing phakic and pseudophakic eyes showed enlarging of the cellular component of the TM area that correlated with the distance between the scleral spur and inner uveal TM. Interestingly there was no increased fibrosis in the TM but rather in the ciliary processes, suggesting this as the primary site of remodeling [39,40 ▪ ]. This would suggest a role for decreased aqueous production.…”

Section: Mechanism Of Intraocular Pressure Reduction In Open Angle Gl...mentioning

confidence: 89%

How much does cataract surgery contribute to intraocular pressure lowering?

Sabharwal,

Garg,

Ramulu

2023

Current Opinion in Ophthalmology

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Purpose of review To review the literature evaluating the effect of cataract surgery on intraocular pressure (IOP) in patients with glaucoma. Recent Findings Recent high-quality secondary analyses of large and primary trials continue to show IOP lowering following cataract surgery. Likewise, cataract surgery remains a key treatment for angle closure glaucoma. Some micro-invasive glaucoma surgeries (MIGS) have strong evidence to be performed at the time of cataract surgery. Data clarifying when these surgeries should be combined with cataract surgery is emerging. The mechanism underlying IOP lowering after cataract surgery remains unclear. Summary Patients who are glaucoma suspects with visually significant cataracts would benefit from cataract surgery alone. Those with mild-moderate damage on 1–2 classes of medications would most likely benefit from additional MIGS. Patients with advanced disease would benefit from cataract surgery and a choice of additional surgery, which depends on disease status and patient factors. Clear lens extraction is becoming a more accepted practice as a primary procedure for patients with angle closure and high IOP or glaucoma. The role of additional MIGS in angle closure needs further study.

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Section: Mechanism Of Intraocular Pressure Reduction In Open Angle Gl...mentioning

confidence: 89%

How much does cataract surgery contribute to intraocular pressure lowering?

Sabharwal,

Garg,

Ramulu

2023

Current Opinion in Ophthalmology

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“…A low vault can lead to mechanical friction between the IOL and the natural lens and obstruction of atrial water circulation in front of the natural lens, which can lead to the development of anterior subcapsular clouding and cataract formation [8][9] . Conversely, if the vault is too high, it can close the anterior chamber angle leading to the development of angle-closure glaucoma, and it can increase friction between the posterior surface of the iris and the IOL leading to increased pigment spreading syndrome, iris atrophy, and inflammation [10][11][12][13] . ICLs are available in four sizes, 12.1, 12.6, 13.2 and 13.7 mm, and choosing the right ICL size is key to achieving the desired vault after surgery.…”

Section: Introductionmentioning

confidence: 99%

Untitled

2023

Int J Ophthalmol

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AIM:To analyze ultrasound biomicroscopy (UBM) images using random forest network to find new features to make predictions about vault after implantable collamer lens (ICL) implantation.• METHODS: A total of 450 UBM images were collected from the Lixiang Eye Hospital to provide the patient's preoperative parameters as well as the vault of the ICL after implantation. The vault was set as the prediction target, and the input elements were mainly ciliary sulcus shape parameters, which included 6 angular parameters, 2 area parameters, and 2 parameters, distance between ciliary sulci, and anterior chamber height. A random forest regression model was applied to predict the vault, with the number of base estimators (n_estimators) of 2000, the maximum tree depth (max_depth) of 17, the number of tree features (max_features) of Auto, and the random state (random_state) of 40.0.• RESULTS: Among the parameters selected in this study, the distance between ciliary sulci had a greater importance proportion, reaching 52% before parameter optimization is performed, and other features had less influence, with an importance proportion of about 5%. The importance of the distance between the ciliary sulci increased to 53% after parameter optimization, and the importance of angle 3 and area 1 increased to 5% and 8% respectively, while the importance of the other parameters remained unchanged, and the distance between the ciliary sulci was considered the most important feature. Other features, although they accounted for a relatively small proportion, also had an impact on the vault prediction. After parameter optimization, the best prediction results were obtained, with a predicted mean value of 763.688 μm and an actual mean value of 776.9304 μm. The R² was 0.4456 and the root mean square error was 201.5166.• CONCLUSION: A study based on UBM images using random forest network can be performed for prediction of the vault after ICL implantation and can provide some reference for ICL size selection.

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Filtering blue light mitigates the deleterious effects induced by the oxidative stress in human retinal pigment epithelial cells

Abdouh

Chen

et al. 2022

Experimental Eye Research

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Histopathological changes in the anterior segment with anterior and posterior chamber intraocular lens

Cited by 3 publications

References 34 publications

How much does cataract surgery contribute to intraocular pressure lowering?

How much does cataract surgery contribute to intraocular pressure lowering?

Untitled

Filtering blue light mitigates the deleterious effects induced by the oxidative stress in human retinal pigment epithelial cells

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