Histopathological Change of Esophagus Related to Dysphagia in Mixed Connective Tissue Disease

Kamataki, Akihisa; Uzuki, Miwa; Sawai, Takashi

doi:10.5772/60509

Cited by 3 publications

(2 citation statements)

References 16 publications

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“…One hypothesis is that autoantibodies attack smooth muscle tissue in the esophagus as well as ganglion cells in the Auerbach plexus, vascular walls, muscular tissue, and squamous epithelium contributing to the dysphagia [7]. Postmortem analysis has shown histopathologic changes more severe in the lower two-thirds of the esophagus and in the inner circular muscular layer of the esophagus [8].…”

Section: Discussionmentioning

confidence: 99%

A Rare Cause of Dysphagia and Weight Loss

Gyorffy

Marowske

Gancayco

2017

American Journal of Gastroenterology

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Mixed connective tissue disease (MCTD) is a rare connective tissue disorder with clinical features that overlap with systemic lupus erythematous, systemic sclerosis, and polymyositis. We report the case of a patient who presented with dysphagia, 25-lb weight loss, difficulty opening her mouth, and joint pain. Dysphagia workup showed a normal barium swallow and normalappearing EGD but esophageal manometry consistent with severe dysmotility. Through further laboratory and imaging studies, the patient met the diagnostic criteria for MCTD. She had marked improvement in her dysphagia with steroids, biologic therapy, and intravenous immunoglobulin.

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Section: Discussionmentioning

confidence: 99%

A Rare Cause of Dysphagia and Weight Loss

Gyorffy

Marowske

Gancayco

2017

American Journal of Gastroenterology

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“…Niektorí autori zastávajú názor, že poškodenie spôsobujú autoprotilátky napádajúce hladkú svalovinu tráviaceho traktu, gangliónové bunky Auerbachového plexu, stenu ciev a svalových vlákien, čo vedie k dysfágií (13). Z jednej štúdie realizovanej postmortem u pacientov s MCTD boli prítomné histopatologické zmeny vnútornej cirkulárnej vrstvy svaloviny, predominantne v dolných 2/3 pažeráku (14).…”

Section: Diskusiaunclassified

Gastrointestinal tract involvement in mixed connective tissue disease (Sharp syndrome)

Nosáková¹,

Schnierer²,

Bánovčin³

et al. 2020

Vnitr Lek

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Interná klinika -gastroenterologická JLF UK a UN Martin, Slovenská republika Sharpov syndróm (mixed connective tissue diseases -MCTD) je veľmi zriedkavé autoimunitné ochorenie spájajúce klinické príznaky systémového lupusu, systémovej sklerózy, polymyozitídy a reumatoidnej artritídy. Klinické prejavy sú veľmi rôznorodé. U niektorých pacientov býva postihnutý tráviaci trakt v rôznom rozsahu. Najčastejšie býva postihnutý pažerák a pacienti sa sťažujú na dysfágiu. Morfologicky je toto postihnutie podobné postihnutiu pažeráka pri systémovej sklerodermii. V tejto kazuistike popisujeme jedinečný prípad ťažkého tráviaceho traktu manifestujúceho sa poruchami motility pažeráka, kachektizáciou, ascitom a opakovanými ileóznymi stavmi.

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Esôfago e autoimunidade

2022

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O acometimento esofágico por doenças autoimunes tem sido cada vez mais reportado na literatura. A incidência e a prevalência de esofagite eosinofílica têm aumentado nas últimas décadas e as opções terapêuticas têm evoluído bastante, mas o corticoide tópico e o uso de inibidores de bombas de prótons permanecem como excelentes opções terapêuticas. Diversas doenças sistêmicas autoimunes podem cursar com acometimento esofágico secundário, com prejuízos da motilidade do corpo esofágico e do esfíncter esofagiano inferior. Esse acometimento se traduz principalmente em disfagia e refluxo gastroesofágico patológico, com suas complicações associadas. Atenção deve ser dada ao tratamento da doença do refluxo gastroesofágico nesses pacientes, de tal forma a melhorar a qualidade de vida e evitar complicações, como esôfago de Barrett e estenoses pépticas. Unitermos: esclerose sistêmica; esofagite eosinofílica; manometria; disfagia; refluxo gastroesofágico.

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Histopathological Change of Esophagus Related to Dysphagia in Mixed Connective Tissue Disease

Cited by 3 publications

References 16 publications

A Rare Cause of Dysphagia and Weight Loss

A Rare Cause of Dysphagia and Weight Loss

Gastrointestinal tract involvement in mixed connective tissue disease (Sharp syndrome)

Esôfago e autoimunidade

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