Histopathological Aspects of The Prognostic Factors for Salivary Gland Cancers

Nishida, Haruto; Kusaba, Takahiro; Kawamura, Kazuhiro; Oyama, Yuzo; Daa, Tsutomu

doi:10.37247/pacr3ed.3.23.4

Cited by 3 publications

(1 citation statement)

References 106 publications

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“…For instance, acinic cell carcinomas and basal cell adenocarcinomas are consistently classified as low-grade, while lymphoepithelial carcinomas and salivary duct carcinomas fall into the high-grade category by definition. The other strategy involves grading entities like mucoepidermoid carcinoma, adenocarcinoma and adenoid cystic carcinoma based on their cytological and histological appearance (2, [7][8][9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Tumor budding - a potential biomarker in low grade salivary gland carcinomas?

Burkhardt,

Kayser,

Villing

et al. 2024

Front. Oncol.

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BackgroundLow-grade salivary gland carcinoma is regularly treated with surgical therapy of the salivary gland without elective neck dissection in T1/2 carcinomas, either alone or with adjuvant radiation therapy. However, occult metastasis and locoregional recurrence influence therapy and outcome. Tumor budding is an emerging prognostic pathological factor in many carcinomas, but has not yet been adequately considered in salivary gland carcinomas.MethodsWe conducted a retrospective single-center study of 64 patients diagnosed with low-grade carcinoma of the major salivary glands treated between 2003 and 2017. Pathological risk factors and TNM classification were thoroughly assessed for each case. All hematoxylin and eosin (HE)-stained histological specimens underwent careful examination, and tumor budding was identified following the guidelines set forth by the International Tumor Budding Consensus Conference in 2016.ResultsTumor budding was not statistically significant concerning 5-year survival rate (5-YSR) (p=0.969) and mean overall survival (log-rank p=0.315). Whereas 5-year disease-free survival rate (5-YDFSR) was 87% in the low tumor budding group and 61.1% in the intermediate and high tumor budding group (p=0.021). Mean disease-free survival accounted for 100.2 months (CI: 88.6;111.9) in the low budding score group and 58.7 months (CI: 42.8;74.6) in the other group (log-rank p=0.032). Notably, pT1/2 showed significantly lower tumor buds than pT3/4 stages (2.43 tumor buds/0.785 mm2 vs. 4.19 tumor buds/0.785 mm2, p=0.034). Similar findings were noted comparing nodal-positive and nodal-negative patients, as well as patients with and without lymphovascular invasion and perineural invasion (each p<0.05).ConclusionsTumor budding might be used as an additional prognostic factor for recurrence in low-grade salivary gland carcinoma, seemingly associated with a higher nodal metastasis rate and advanced tumor stages and a worse 5-YDFSR. Consequently, the evaluation of tumor budding in resection specimens of low-grade salivary gland tumor may prove valuable in decision-making for neck dissection and follow-up strategy.

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Section: Introductionmentioning

confidence: 99%

Tumor budding - a potential biomarker in low grade salivary gland carcinomas?

Burkhardt,

Kayser,

Villing

et al. 2024

Front. Oncol.

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Prognostic Significance of Histopathological Parameters for Salivary Gland Adenoid Cystic Carcinoma

de Morais,

de Farias Morais,

de Almeida Freitas

et al. 2023

Dentistry Journal

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Adenoid cystic carcinoma (ACC) is a rare salivary gland tumor that accounts for approximately 1% of all head and neck cancers. Despite its initial indolent behavior, long-term survival is poor due to locoregional recurrence in approximately 40% and distant metastasis in up to 60% of patients who undergo radical treatment. The histological parameters of ACC and the combination of these parameters in histopathological grading systems provide valuable prognostic information about the clinical course of the disease. Within this context, this review aims to analyze the impact of histopathological parameters, individual or combined in histopathological grading systems of malignancy, on ACC prognosis. Individual histopathological parameters such as solid pattern, presence of tumor necrosis, high-grade transformation, dominance of the epithelial component, presence of perineural and lymphovascular invasion, and positive surgical margins have negative impacts on the survival of patients with ACC. There are currently four histopathological grading systems for ACC; however, few studies have validated these systems and most of them explored small cohorts with short follow-up. Considering that the application of grading systems has been associated with ACC prognosis, a broader validation will allow not only their use for prognostic prediction but also assist in treatment planning.

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Current Developments in Diagnosis of Salivary Gland Tumors: From Structure to Artificial Intelligence

Faur,

Buzaș,

Lăzărescu

et al. 2024

Life

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Salivary glands tumors are uncommon neoplasms with variable incidence, heterogenous histologies and unpredictable biological behaviour. Most tumors are located in the parotid gland. Benign salivary tumors represent 54–79% of cases and pleomorphic adenoma is frequently diagnosed in this group. Salivary glands malignant tumors that are more commonly diagnosed are adenoid cystic carcinomas and mucoepidermoid carcinomas. Because of their diversity and overlapping features, these tumors require complex methods of evaluation. Diagnostic procedures include imaging techniques combined with clinical examination, fine needle aspiration and histopathological investigation of the excised specimens. This narrative review describes the advances in the diagnosis methods of these unusual tumors—from histomorphology to artificial intelligence algorithms.

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Histopathological Aspects of The Prognostic Factors for Salivary Gland Cancers

Abstract: We describe the currently known histopathological aspects of the prognostic factors for salivary gland cancers and discuss the genetics or molecules used as diagnostic tools, which might serve as treatment targets in the future.

Cited by 3 publications

References 106 publications

Tumor budding - a potential biomarker in low grade salivary gland carcinomas?

Tumor budding - a potential biomarker in low grade salivary gland carcinomas?

Prognostic Significance of Histopathological Parameters for Salivary Gland Adenoid Cystic Carcinoma

Current Developments in Diagnosis of Salivary Gland Tumors: From Structure to Artificial Intelligence

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