Histopathological and immunohistochemical studies of intracranial nervous-system tumours in four cattle

Yamada, Michio; Nakagawa, Miho; Yamamoto, Miyuki; Furuoka, Hidefumi; Matsui, Takane; Taniyama, Hiroyuki

doi:10.1016/s0021-9975(98)80073-x

Cited by 18 publications

(24 citation statements)

References 13 publications

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“…Clinic signs for cattle with neoplasms of the choroid plexus depend on the anatomical location of the tumor and the resultant compression on adjacent structures. Circling and head tilt to the right side, and ataxia were observed in a case of plexus papilloma of fourth ventricle in a bovine (YAMADA et al, 1998) and progressive ataxia, ventromedial strabismus and hyperaesthesia were reported in a cow with choroid plexus papilloma of the third ventricle (HOENERHOFF et al, 2006). In the present case, the affected cow presented anorexia, weight loss, incoordination and corneal opacity.…”

Section: Palavras-chave: Doenças De Bovinos Neoplasmas Neuropatologiasupporting

confidence: 49%

Choroid plexus carcinoma in a cow

et al. 2009

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Section: Palavras-chave: Doenças De Bovinos Neoplasmas Neuropatologiasupporting

confidence: 49%

Choroid plexus carcinoma in a cow

et al. 2009

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“…In cattle, three reports describe this neoplastic lesion (Luginbuhl et al 1968;Yamada et al 1998;Hoenerhoff et al 2006). In a series of 1,093 bovine necropsy specimens, Yamada et al (1998) identified only four primary intracranial nervous system tumours, one of which was diagnosed as a choroid plexus papilloma.…”

Section: Discussionmentioning

confidence: 99%

“…In a series of 1,093 bovine necropsy specimens, Yamada et al (1998) identified only four primary intracranial nervous system tumours, one of which was diagnosed as a choroid plexus papilloma. In 2006 Hoenerhoff et al described gross, microscopical, immunohistochemical and ultrastructural findings of a choroid plexus papilloma in a Scottish Highland cow.…”

Section: Discussionmentioning

confidence: 99%

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Choroid plexus papilloma in an adult ewe – a case report

González¹,

Lacasta

Sanz

et al. 2013

Acta Vet. Brno

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Primary neoplasms of the central nervous system have been rarely reported in sheep. A threeyear-old Rasa Aragonesa ewe was admitted to the small ruminant external consultancy at the Veterinary Faculty of University of Zaragoza, Spain. Clinical, haematological and neurological examinations were performed. Neurological examination showed signs of ataxia, hyperextension of the right front limb and abnormal postural reactions. The animal was unable to stand and walk, even with help. Patellar and flexor reflexes were normal and superficial sensation was present but decreased. Humanitarian sacrifice was carried out one month later. Gross and histopathological findings revealed a choroid plexus papilloma located in the fourth ventricle of the brain. To the authors' knowledge this is the first description of this neoplastic disorder in sheep. Sheep, central nervous system, pathology, choroid plexus papilloma, primary neoplasmPrimary neoplasms of the central nervous system (CNS) have been rarely reported in sheep (Olson et al. 1981; González et al. 1994;Oda et al. 1997;Roels et al. 2001;Zanolari et al. 2004; Ortin et al. 2006;Derakhshanfar and Mozaffari 2010). Choroid plexus papilloma in sheep and goat has not been described in the literature. Furthermore, only three cases of this tumour have been reported in cattle (Luginbuhl et al. 1968;Yamada et al. 1998;Hoenerhoff et al. 2006).The present report describes the clinical presentation and histopathological findings of an ovine choroid plexus papilloma. Clinical presentationA three-year-old Rasa Aragonesa ewe was admitted to the small ruminant external consultancy at Veterinary Faculty of University of Zaragoza, Spain. The affected ewe showed neurological signs. The animal had a 2-week history of progressive ataxia, followed by recumbency, holding the head to the right side (Plate I, Fig. 1).The ewe was kept at the facilities for one month and clinical, haematological and neurological examinations were performed. At examination, the ewe showed normal heart and respiratory rates (105 beats/min and 58 bpm) and rectal temperature was 39 ºC. Haematological indicators retrieved were within the normal range. Neurological examination confirmed signs of ataxia. Hyperextension of the right front limb and abnormal postural reactions were observed. The animal was unable to stand and walk, even with help. Patellar and flexor reflexes were normal and superficial sensation was present but decreased. Post mortem findingsDue to the poor body condition and bad prognosis, the animal was euthanized. A humanitarian sacrifice was carried out with 200 mg pentobarbital sodium (product Dolethal ® , 0.7 ml/kg, Vetoquinol UK Ltd.), and necropsy was performed.

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“…Although keratin is broadly expressed in epithelial cells (Albers and Fuchs 1992), it has also been detected recently in normal nervous tissue, such as the bovine neural plate (MaddoxHyttel et al 2003), mouse neural crest cells (Katagata et al 1999), radial glia of the human spinal cord (Walder et al 2003), rat ependymal cells (Kasper 1992), neurons of the human cochlea spiral ganglion (Anniko et al 1990;Okabe et al 1997) and neurons of the adult rabbit spinal ganglion (Iwatsuki and Suda 2005b). In addition, keratin has also been detected in the cells of the following tumors of the nervous system: paragangliomas (Moran et al 1997;Chetty et al 1998), spinal ependymomas (Takeuchi et al 2002), schwannomas (Guarino 1993), choroid plexus papillomas (Yamada et al 1998), astrocytomas (Yamada et al 1998) and oligodendrogliomas (Kashima et al 1993). Since keratin has been detected not only in undifferentiated neuronal cells but also in dedifferentiated tumor cells of the nervous system, it seems that keratin, in addition to nestin, could also be utilized as a valuable histochemical marker for nervous system stem cells.…”

Section: Introductionmentioning

confidence: 99%

Transient expression of keratin during neuronal development in the adult rabbit spinal ganglion

Iwatsuki

Suda

2009

Anat Sci Int

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A few neurons of the adult rabbit spinal ganglion express keratin. To examine the characters of these keratin-positive neurons, six kinds of intermediate filament proteins, namely keratin 8, keratin 14, nestin, vimentin, neurofilament 68 (NF-L) and glial fibrillary acidic protein (GFAP), were investigated immunohistochemically in developing and adult rabbit spinal ganglia. At 15 days of gestation, the spinal ganglion increased rapidly in volume and mainly consisted of three kinds of cells: small cells expressing vimentin, spindle-shaped cells co-expressing vimentin and nestin, and ovoid cells with an eccentric nucleus expressing nestin. Since some ovoid cells coexpressed nestin with either NF-L or GFAP, the ovoid cell may be considered to be an embryonic neural stem cell of the ganglion. In addition, a few keratin-positive polymorphic cells could be observed among these three kinds of cells. These polymorphic cells expressed five kinds of intermediate filament proteins, namely keratin 8, keratin 14, nestin, NF-L and GFAP. These cells were also detected in newborn and adult ganglia. A few neurons in the adult ganglion also expressed these five kinds of proteins as a Golgi-associated network. However, neurons expressing these proteins could not be detected in embryonic and newborn ganglia. Therefore, it may be considered that the keratin-positive polymorphic cell is a postnatal neural stem cell of the ganglion and that neurons transiently express keratin when polymorphic cells differentiate into neurons.

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Histopathological and immunohistochemical studies of intracranial nervous-system tumours in four cattle

Cited by 18 publications

References 13 publications

Choroid plexus carcinoma in a cow

Choroid plexus carcinoma in a cow

Choroid plexus papilloma in an adult ewe – a case report

Transient expression of keratin during neuronal development in the adult rabbit spinal ganglion

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