Histopathological and Immunohistochemical Comparison of the Brain of Human Patients with Alzheimer’s Disease and the Brain of Aged Dogs with Cognitive Dysfunction

Yu, Chi Ho; Song, Geun Seog; Yhee, Ji Young; Kim, Jong Hyuk; Im, Keum Soon; Nho, W. G.; Lee, J. H.; Sur, Jung-Hyang

doi:10.1016/j.jcpa.2010.11.004

Cited by 65 publications

(70 citation statements)

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“…66 In a study of cognitively impaired pet dogs that included a variety of breeds, intracellular phosphorylated tau was observed that was similar to the AD brain. 67 …”

Section: Neurobiology Of Aging In the Dogmentioning

confidence: 99%

Aging in the Canine and Feline Brain

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2014

Veterinary Clinics of North America: Small Animal Practice

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“…66 In a study of cognitively impaired pet dogs that included a variety of breeds, intracellular phosphorylated tau was observed that was similar to the AD brain. 67 …”

Section: Neurobiology Of Aging In the Dogmentioning

confidence: 99%

Aging in the Canine and Feline Brain

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Head

2014

Veterinary Clinics of North America: Small Animal Practice

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“…Despite controversy regarding the mechanistic pathways involved in the CNS damage associated with exposure to air pollutants, specifically fine and ultrafine particles of diverse origin, animal models and tissue culture studies have greatly improved our understanding of the mechanistic processes [39, 41, 42, 48–52, 58–66, 69–71]. We are looking forward to bridging the gap between early neuroinflammation and neurodegeneration observed in childhood and early adulthood and experimental air pollution animal models.…”

Section: Compensatory Responses Versus Neurotoxic and Neurodegenermentioning

confidence: 99%

Early Alzheimer’s and Parkinson’s Disease Pathology in Urban Children: Friend versus Foe Responses—It Is Time to Face the Evidence

Calderón‐Garcidueñas

Franco-Lira

Mora-Tiscareño

et al. 2013

BioMed Research International

106

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Chronic exposure to particulate matter air pollution is known to cause inflammation leading to respiratory- and cardiovascular-related sickness and death. Mexico City Metropolitan Area children exhibit an early brain imbalance in genes involved in oxidative stress, inflammation, and innate and adaptive immune responses. Early dysregulated neuroinflammation, brain microvascular damage, production of potent vasoconstrictors, and perturbations in the integrity of the neurovascular unit likely contribute to progressive neurodegenerative processes. The accumulation of misfolded proteins coincides with the anatomical distribution observed in the early stages of both Alzheimer's and Parkinson's diseases. We contend misfolding of hyperphosphorylated tau (HPπ), alpha-synuclein, and beta-amyloid could represent a compensatory early protective response to the sustained systemic and brain inflammation. However, we favor the view that the chronic systemic and brain dysregulated inflammation and the diffuse vascular damage contribute to the establishment of neurodegenerative processes with childhood clinical manifestations. Friend turns Foe early; therefore, implementation of neuroprotective measures to ameliorate or stop the inflammatory and neurodegenerative processes is warranted in exposed children. Epidemiological, cognitive, structural, and functional neuroimaging and mechanistic studies into the association between air pollution exposures and the development of neuroinflammation and neurodegeneration in children are of pressing importance for public health.

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“…Clinical diagnosis of possible cognitive dysfunction may be made in the presence of other significant diseases (McKann et al 1984). The aged dog brain could be a useful model for understanding the pathogenesis of early AD, and these animals represent a valuable resource for the preclinical testing of therapeutic approaches that could be used to diagnose and treat this devastating disorder in man (Yu et al 2011).…”

Section: Behavior Diagnosismentioning

confidence: 99%

“…The reason for the absence of these protein aggregates in dogs with cognitive decline remains poorly understood. One presumption is that the earlier death of dogs precludes this protein accumulation (Yu et al 2011). Yu et al (2011) detected moderate levels of ubiquitin in the cerebral cortices and hippocampi of humans with Alzheimer´s disease.…”

Section: Introductionmentioning

confidence: 99%

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Cognitive dysfunction syndrome: updated behavioral and clinical evaluations as a tool to evaluate the well-being of aging dogs

et al. 2014

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Cognitive dysfunction syndrome: updated behavioral and clinical evaluations as a tool to evaluate the well-being of aging dogsSíndrome de disfunción cognitiva: actualización del conocimiento como herramienta para el bienestar animal en perros seniles RESUMENLa mejora en la atención veterinaria, la nutrición y el enriquecimiento del entorno doméstico ha facilitado que cada vez haya un mayor número de perros que vivan su etapa senil. Sin embargo, se debe tener en cuenta que una mayor longevidad implica una mayor prevalencia de problemas cognitivos en nuestras mascotas. A lo largo de su vida geriátrica los perros son más vulnerables a padecer síndromes demenciales neurodegenerativos de carácter progresivo. Una de las enfermedades neurodegenerativas que actualmente está siendo objeto de estudio por su elevada prevalencia es el síndrome de disfunción cognitiva. La enfermedad es una entidad neurocomportamental que se presenta en perros ancianos, caracterizado por un déficit en el aprendizaje, en la memoria y en la conciencia espacial del perro, además de ser un trastorno clínico que tiene un impacto significativo en la vida de los perros de edad avanzada y sus propietarios. La escasez de pruebas diagnósticas de alta confiabilidad que garanticen la presencia o no de la enfermedad, otorga a la identificación temprana de los signos clínicos, un papel crucial para el establecimiento de un buen pronóstico en términos de mejoría y extensión en la calidad de vida de los pacientes afectados. El tratamiento debe dirigirse a frenar la progresión de la pérdida de cognición, mediante la instauración de técnicas y programas que mejoren la actividad física, los aspectos nutricionales y el ambiente del animal. Por lo tanto, son necesarias futuras investigaciones en el conocimiento, control y prevención de esta patología, para disminuir el impacto generado por sus efectos sobre la calidad de vida de los perros y sus propietarios.Palabras clave: síndrome de disfunción cognitiva, perros, proteína β-amiloidea. SUMMARYImprovements in veterinary medicine, nutrition and the enrichment of the domestic environment have helped more dogs reach to their senile phase. However, greater longevity leads to a higher prevalence of cognitive problems in our pets. Throughout their geriatric lives, dogs are more vulnerable to suffering progressive neurodegenerative dementia syndromes. Due to its high prevalence, cognitive dysfunction syndrome is one of the most studied neurodegenerative diseases. This disease is a neurobehavioral entity that presents itself in senile dogs, and it is characterized by a deficit in learning, memory and the dog's spatial awareness. It is a clinical disorder that has a significant impact on older dogs and their owners. There is a lack of reliable diagnostic tests that can guarantee the presence of the disease, provide early identification of the clinical signs of this disease, or establish a prognosis in terms of the recovery and expansion of the quality of life of the affected patient. Treatment should be directed at slowi...

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Histopathological and Immunohistochemical Comparison of the Brain of Human Patients with Alzheimer’s Disease and the Brain of Aged Dogs with Cognitive Dysfunction

Cited by 65 publications

References 50 publications

Aging in the Canine and Feline Brain

Aging in the Canine and Feline Brain

Early Alzheimer’s and Parkinson’s Disease Pathology in Urban Children: Friend versus Foe Responses—It Is Time to Face the Evidence

Cognitive dysfunction syndrome: updated behavioral and clinical evaluations as a tool to evaluate the well-being of aging dogs

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