Histopathological and immunohistochemical analysis of calcifying odontogenic cysts

Yoshida, Mitsuhide; Kumamoto, Hiroyuki; Ooya, Kiyoshi; Mayanagi, Hideaki

doi:10.1034/j.1600-0714.2001.301002.x

Cited by 55 publications

(52 citation statements)

References 21 publications

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“…In CCOT, cytokeratins 14 and 19 have been identified in the epithelial component, with CK6 expression in both the epithelium and ghost cells [38]. The proliferation fraction, as assessed by Ki-67, is very similar to ameloblastoma, particularly in those lesions where the lining is obviously ameloblastoma-like [39,40]. The solid lesions show a similar immunophenotype [41].…”

Section: Lesions Containing Ghost Cellsmentioning

confidence: 75%

The Diagnostic Usefulness of Immunohistochemistry for Odontogenic Lesions

Hunter

Speight

2014

Head and Neck Pathol

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The diagnosis of odontogenic tumors can be challenging, largely due to their rarity and consequent difficulties in gaining experience in their assessment. In most cases, careful attention to morphology, in conjunction with clinical and radiological features will allow a diagnosis to be made. However, in some cases, immunohistochemical analysis of the tumor may be useful. In this review we will outline the immunohistochemical expression profile of normal developing odontogenic tissues and a range of odontogenic tumors. In many cases the immunohistochemical markers are neither specific nor sensitive enough to be of help in diagnosis, but in some cases such analysis may prove very useful. Thus we have outlined a limited number of circumstances where immunohistochemistry may be of use to the practicing diagnostic pathologist.

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Section: Lesions Containing Ghost Cellsmentioning

confidence: 75%

The Diagnostic Usefulness of Immunohistochemistry for Odontogenic Lesions

Hunter

Speight

2014

Head and Neck Pathol

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“…It is clinically characterized as a painless-slow-growing tumor, that affects the maxilla as well as the mandible, and generally occurs in young adults in the third or fourth decade of life. It exhibits no sexual predilection and is most commonly seen in the anterior region [7] [8]. CCOT can present alone, as in the present case, or is associated with other odontogenic tumors, such as odontomas, adenomatoid odontogenic tumors, and ameloblastomas [9].…”

Section: Discussionmentioning

confidence: 90%

“…In the 8 cases, the patient age ranged from 5 to 45 years, with a mean age of The discussion about the neoplastic behavior of CCOT is still recent. Yoshida et al [7] The recommended treatment for CCOT is usually conservative and consists of enucleation with curettage, i.e., enucleation followed by removal of a 1 -2 mm layer of bone around the complete periphery of the cystic cavity with a sharp curette or a bone bur [13]. The purpose of this procedure is to remove epithelial debris that could turn into a recurrent lesion.…”

Section: Discussionmentioning

confidence: 99%

A Large Calcifying Cystic Odontogenic Tumor Occupying the Maxillary Sinus: A Case Report and Review of Literature

Nakamura¹,

Tamaki²,

Yamakawa³

et al. 2017

OJST

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Calcifying cystic odontogenic tumor (CCOT) is an uncommon benign cystic neoplasm of the jaw that develops from the odontogenic epithelium. It is clinically characterized as a painless-slow-growing tumor that affects the maxilla as well as the mandible, and generally occurs in young adults in the third or fourth decade of life. Herein, we present the case of a 16-year-old Japanese boy who showed a CCOT in the maxillary sinus. Panoramic radiography showed a unilocular lesion in the left maxillary sinus. Computed tomography showed an approximately 5-cm well-defined unilocular expansile lesion with multiple radiopaque calcific specks, arising from the left maxillary alveolar ridge. The lesion was surgically removed, under general anesthesia, and the patient was followed up for 3 years after the surgery, and there have not been any signs of recurrence.

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“…Takata (10) found that the mean PCNA labeling index in the nonproliferative type was lower than that in the proliferative type, and that in the malignant COC was higher than in benign COC. Yoshida et al (16) also found that the mean Ki-67 labeling index was slightly greater in proliferative COC, combined COC or COC with ameloblastomatous proliferation than in those without these histological features, and that the proportion of cases positive for bcl-2 was slightly higher in COCs with odontoma than in those without odontoma.…”

Section: Discussionmentioning

confidence: 93%

Immunohistochemical analysis of p53 and PCNA expression in calcifying odontogenic cyst

et al. 2010

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Calcifying odontogenic cyst (COC) is adevelopmental odontogenic cyst in the jaw. Because of its diverse histopathologic features and biological behavior, there has long been confusion with regard to its nature as a cyst or neoplasm. This study evaluated the proliferative activity of 57 COC samples, including simple cyst (10 cases), cystic neoplasm (34 cases), solid neoplasm (6 cases) and combined lesion (7 cases) by p53 and PCNA immunohistochemical staining. For assessment of p53 and PCNA positivity, the number of positively stained cells with brown-stained nuclei was counted in 1000 cells from each sample. p53 and PCNA expression in the solid neoplasm subtype were significantly higher when compared to cystic neoplasm and simple cyst (P < 0.05). The lowest p53 and PCNA expression was found in the simple cyst subtype. p53 and PCNA expression in the basal and suprabasal layers was significantly higher in the solid subtype when compared to others, and the difference between COC groups was significant. The results demonstrated that within benign types of COC, the amount of p53 and PCNA in proliferative epithelium is significantly higher when compared to non-proliferative epithelium.

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Histopathological and immunohistochemical analysis of calcifying odontogenic cysts

Abstract: We conclude that COCs with various histological features have neoplastic potential and may not be separate entities within the same histological spectrum.

Cited by 55 publications

References 21 publications

The Diagnostic Usefulness of Immunohistochemistry for Odontogenic Lesions

The Diagnostic Usefulness of Immunohistochemistry for Odontogenic Lesions

A Large Calcifying Cystic Odontogenic Tumor Occupying the Maxillary Sinus: A Case Report and Review of Literature

Immunohistochemical analysis of p53 and PCNA expression in calcifying odontogenic cyst

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