Histopathological and Functional Evaluation of Radiation-Induced Sciatic Nerve Damage: Melatonin as Radioprotector

Shabeeb, Dheyauldeen; Musa, Ahmed Eleojo; Keshavarz, Mansoor; Esmaely, Farid; Hassanzadeh, Gholamreza; Shirazi, Alireza; Najafi, Masoud

doi:10.3390/medicina55080502

Cited by 10 publications

(14 citation statements)

References 67 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…RT mainly targets tumour cells; however, when irradiating the tumour with the appropriate dose, it is often impossible not to affect the surrounding tissues. RIPND is the least known and perhaps the most frightening of the late complications of RT [10]. This is because permanent damage (sensory and/or motor) may occur in the extremities both in the early stages of the disease and even years after its remission.…”

Section: Discussionmentioning

confidence: 99%

“…[11,12]. Superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase (CAT) are antioxidant enzymes that protect cells against free radical damage [10]. Since the mid-19th century, many chemical compounds, including antioxidant agents, have been used to reduce these side effects of IR [10,[14][15][16].…”

Section: Marmara Medical Journalmentioning

confidence: 99%

“…Superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase (CAT) are antioxidant enzymes that protect cells against free radical damage [10]. Since the mid-19th century, many chemical compounds, including antioxidant agents, have been used to reduce these side effects of IR [10,[14][15][16]. Annona muricata (AM) (Graviola), the tropical tree from the Annonaceae family, consists of evergreen dark green leaves and heart-shaped fruits [13].…”

Section: Marmara Medical Journalmentioning

confidence: 99%

“…Therefore, the patients face additional stress and it reduces the patients' quality of life. Due to IR, neuron damage is closely related to early biochemical and histomorphological changes and late scar formation [9,10]. The mechanism of all these changes occurs due to the process that results in cell death due to DNA damage.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

The neuroprotective and anti-inflammatory effects of Annona muricata (Graviola) on radiation-induced rat sciatic nerve injury

KESKIN¹,

ELMAS²,

SAHIN³

et al. 2022

Marmara Medical Journal

View full text Add to dashboard Cite

Objective: This study aimed to evaluate Annona muricata's (AM) radioprotective effects on sciatic nerve injury due to ionising radiation (IR). Materials and Methods: Thirty-two adult female Wistar albino rats were separated into four equal groups; Control (C), Annona muricata leaf extracts (AME), radiation (RAD), radiation and AME (AME+RAD). In groups AME and AME+RAD, AME was administered at a dose of 300 mg/kg for the first day and 50 mg/every day for the following one week intraperitoneally. In RAD and AME+RAD, rats were exposed to a single dose of 20 Gray (Gy) IR to their right legs. All the subjects were sacrificed at the end of the first month. Oxidative stress biochemical parameters from blood samples were analysed. In addition, right sciatic nerves were extracted and histomorphology was evaluated. Results: Statistically significant vasculature, degenerative and necrotic changes were observed in RAD, compared to C and AME (p<0.01). Swelling in myelin sheath was predominantly seen in RAD. Alterations in the level of catalase (p<0.01), superoxide dismutase (p<0.01) and glutathione peroxidase (p<0.05) in the AME+RAD group compared to the RAD group were found to be statistically significant. Conclusion: Our study unveiled that AM could potentially enhance biochemical and histomorphological healing in the acute period on sciatic nerve injury due to IR.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Marmara Medical Journalmentioning

confidence: 99%

Section: Marmara Medical Journalmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The neuroprotective and anti-inflammatory effects of Annona muricata (Graviola) on radiation-induced rat sciatic nerve injury

KESKIN¹,

ELMAS²,

SAHIN³

et al. 2022

Marmara Medical Journal

View full text Add to dashboard Cite

show abstract

“…The history of traditional herb medicine dates back to a long time ago, however, during the recent decades owing to the considerable positive impacts of herbals (Aliasgharzadeh et al, ; Farhood et al, ; Mortezaee et al, ; Najafi et al, ; Shabeeb et al, ) and noticeable side effects of chemical drugs, much attention has been made in pharmacognosy (Farhood et al, , , , ; Najafi et al, ). In other words, the harmful effects of synthetic drugs lead to the substitution of natural compounds for the remediation of a number of disorders (Azmoonfar et al, ; Farhood et al, ; Kolivand et al, ; Shabeeb et al, ).…”

Section: Introductionmentioning

confidence: 99%

Therapeutic effects of kaempferol affecting autophagy and endoplasmic reticulum stress

Ashrafizadeh

Tavakol

Ahmadi

et al. 2019

Phytotherapy Research

View full text Add to dashboard Cite

Regulated cell death (RCD) guarantees to preserve organismal homeostasis. Apoptosis and autophagy are two major arms of RCD, while endoplasmic reticulum (ER) as a crucial organelle involved in proteostasis, promotes cells toward autophagy and apoptosis. Alteration in ER stress and autophagy machinery is responsible for a great number of diseases. Therefore, targeting those pathways appears to be beneficial in the treatment of relevant diseases. Meantime, among the traditional herb medicine, kaempferol as a flavonoid seems to be promising to modulate ER stress and autophagy and exhibits protective effects on malfunctioning cells. There are some reports indicating the capability of kaempferol in affecting autophagy and ER stress. In brief, kaempferol modulates autophagy in noncancerous cells to protect cells against malfunction, while it induces cell mortality derived from autophagy through the elevation of p-AMP-activated protein kinase, light chain-3-II, autophagy-related geness, and Beclin-1 in cancer cells. Noteworthy, kaempferol enhances cell survival through C/EBP homologous protein (CHOP) suppression and GRP78 increment in noncancerous cells, while it enhances cell mortality through the induction of unfolding protein response and CHOP increment in cancer cells. In this review, we discuss how kaempferol modulates autophagy and ER stress in noncancer and cancer cells to expand our knowledge of new pharmacological compounds for the treatment of associated diseases. K E Y W O R D S apoptosis, autophagy, cell death, endoplasmic reticulum stress, flavonoid, kaempferol

show abstract

Potential therapeutic effects of curcumin mediated by JAK/STAT signaling pathway: A review

Ashrafizadeh

Rafiei

Mohammadinejad

et al. 2020

Phytotherapy Research

View full text Add to dashboard Cite

Curcumin is a naturally occurring nutraceutical compound with a number of therapeutic and biological activities such as antioxidant, anti‐inflammatory, anti‐diabetic, antitumor, and cardioprotective. This plant‐derived chemical has demonstrated great potential in targeting various signaling pathways to exert its protective effects. Signal transducers and activator of transcription (STAT) is one of the molecular pathways involved in a variety of biological processes such as cell proliferation and cell apoptosis. Accumulating data demonstrates that the STAT pathway is an important target in treatment of a number of disorders, particularly cancer. Curcumin is capable of affecting STAT signaling pathway in induction of its therapeutic impacts. Curcumin is able to enhance the level of anti‐inflammatory cytokines and improve inflammatory disorders such as colitis by targeting STAT signaling pathway. Furthermore, studies show that inhibition of JAK/STAT pathway by curcumin is involved in reduced migration and invasion of cancer cells. Curcumin normalizes the expression of JAK/STAT signaling pathway to exert anti‐diabetic, renoprotective, and neuroprotective impacts. At the present review, we provide a comprehensive discussion about the effect of curcumin on JAK/STAT signaling pathway to direct further studies in this field.

show abstract

Histopathological and Functional Evaluation of Radiation-Induced Sciatic Nerve Damage: Melatonin as Radioprotector

Cited by 10 publications

References 67 publications

The neuroprotective and anti-inflammatory effects of Annona muricata (Graviola) on radiation-induced rat sciatic nerve injury

The neuroprotective and anti-inflammatory effects of Annona muricata (Graviola) on radiation-induced rat sciatic nerve injury

Therapeutic effects of kaempferol affecting autophagy and endoplasmic reticulum stress

Potential therapeutic effects of curcumin mediated by JAK/STAT signaling pathway: A review

Contact Info

Product

Resources

About