Histopathological and clinical evaluation of chronic spontaneous urticaria patients with neutrophilic and non-neutrophilic cutaneous infiltrate

Martins, Charles Ferreira; Morais, Karina Lopes; Figueroa, Pamela; Dias, Natália Martins; Valente, Neusa Yuriko Sakai; Maruta, Celina Wakisaka; Criado, Paulo Ricardo

doi:10.1016/j.alit.2017.06.012

Cited by 16 publications

(11 citation statements)

References 18 publications

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“…As reported in other studies on urticaria, 15,18 intravascular and extravascular neutrophils (perivascular and interstitial) were observed in most patients, with similar frequencies in both groups. They were not the predominant cell type in none of the cases, and systemic symptoms and laboratory workup were not consistent with the diagnosis of neutrophilic urticarial dermatosis or a neutrophilic autoinflammatory syndrome 6,25,26 …”

Section: Discussionsupporting

confidence: 87%

“…In the whole cohort, we observed the classic histopathological findings of urticaria, namely dermal edema and a perivascular infiltrate composed of eosinophils, neutrophils, lymphocytes, and mast cells 4,15‐17 . In most cases, as reported by Barzilai et al, 18 the inflammatory infiltrate also had a deep component involving the reticular dermis and extending beyond the perivascular area to the interstitium, particularly in CSU with bruising.…”

Section: Discussionsupporting

confidence: 65%

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Histopathology of chronic spontaneous urticaria with occasional bruising lesions is not significantly different from urticaria with typical wheals

et al. 2021

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Background Chronic spontaneous urticaria (CSU) may occasionally exhibit long‐lasting lesions with bruising, usually considered a hallmark of urticarial vasculitis (UV). Histopathology of these chronic urticarial lesions has not been extensively studied. Methods Skin biopsies from patients with anti‐H1 resistant CSU were evaluated for several parameters (edema, location, intensity, and cell composition of the inflammatory infiltrate, and abnormalities in the blood vessels). Results We studied 45 patients (37 female/8 male, mean age 49.3 years) with CSU, 60% of whom with occasional bruising lesions and 3 patients with hypocomplementemic UV. Histopathology in CSU showed mainly perivascular and interstitial inflammatory infiltrate (91.1%), including eosinophils (80%), neutrophils (77.8%), and lymphocytes (71.1%), vasodilatation (88.9%), intravascular neutrophils (95.6%), dermal edema (51.1%), swelling of endothelial cells (51.1%), and minor and rare fibrinoid necrosis and karyorrhexis (6.7%). Significant karyorrhexis and frank fibrinoid necrosis were observed, respectively, in two and three cases of UV. In patients with occasional bruising, mast cells occurred in fewer cases whereas eosinophils were more frequent, but no statistically significant difference was found for other parameters. Conclusions Histopathological findings were not significantly different between CSU with or without bruising lesions. Bruising may be associated with more severe forms of CSU with no histopathological signature, although UV cannot be completely excluded based on histopathology.

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Section: Discussionsupporting

confidence: 87%

Section: Discussionsupporting

confidence: 65%

Histopathology of chronic spontaneous urticaria with occasional bruising lesions is not significantly different from urticaria with typical wheals

et al. 2021

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“…IL-17A stimulates the production of proin ammatory cytokines like IL-1 and IL-6 and adhesion molecules [7]. It plays a role in recruitment of neutrophils present in urticarial in ltrate [8,22]. Together with IL-23, it is involved in the development of autoimmune mechanisms, which is of particular importance for CU [7,21].…”

Section: Discussionmentioning

confidence: 99%

Assessment of selected interleukins (IL-6, IL-17A, IL-18, IL-23) and chemokines (RANTES, IP-10) in children with acute and chronic urticaria

Góra

Przybył

Świętochowska

et al. 2022

Preprint

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Background Urticarial lesions develop as a result of the activation of mast cells which, through the release of mediators, influence the formation of local inflammatory infiltrates. Changes in the expression of many cytokines and chemokines are observed in the course of urticaria.The aim of the study was to evaluate serum levels of interleukin (IL)-6, IL-17A, IL-18, IL-23, regulated on activation, normal T cell expressed and secreted (RANTES) and interferon (IFN)-γ-inducible protein-10 (IP-10) in children with acute and chronic urticaria in comparison to healthy volunteers. Moreover, we made an attempt to identify factors predicting the occurrence and course of urticaria among the studied parameters.MethodsWe retrospectively analyzed 32 children with acute urticaria and 32 children with chronic urticaria. The control group consisted of 40 healthy children. Each patient was clinically evaluated. Serum concentrations of selected cytokines and chemokines were determined by using enzyme-linked immunosorbent assay.ResultsPatients with acute and chronic urticaria had higher concentrations of IL-6 and IL-17A (p<0.001) and lower concentrations of IL-18, IL-23, RANTES and IP-10 (p<0.001) as compared to the control group. IL-6 and IP-10 showed high predictive values for the development of urticaria. There was no correlation of the studied cytokines and chemokines with disease activity.ConclusionsIn children with acute and chronic urticaria, the cytokine profile differs compared to healthy subjects. IL-6 and IP-10 are useful in differentiating children with urticaria and healthy ones. The search for factors predicting the course of the disease requires further studies.

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“…Actuellement, il n'existe pas de consensus ni de définition précise des UN. Certains auteurs considèrent que cette entité ne peut pas être individualisée et que les lésions histologiques décrites correspondent à de simples urticaires riches en neutrophiles [7,8].…”

Section: Méthodesunclassified

Qu’est-ce que l’urticaire neutrophilique ?

Monfort

Moguelet

Amsler

et al. 2019

Annales de Dermatologie et de Vénéréologie

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Histopathological and clinical evaluation of chronic spontaneous urticaria patients with neutrophilic and non-neutrophilic cutaneous infiltrate

Abstract: There is not enough scientific evidence to support neutrophilic urticaria as a solid, separate entity.

Cited by 16 publications

References 18 publications

Histopathology of chronic spontaneous urticaria with occasional bruising lesions is not significantly different from urticaria with typical wheals

Histopathology of chronic spontaneous urticaria with occasional bruising lesions is not significantly different from urticaria with typical wheals

Assessment of selected interleukins (IL-6, IL-17A, IL-18, IL-23) and chemokines (RANTES, IP-10) in children with acute and chronic urticaria

Qu’est-ce que l’urticaire neutrophilique ?

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