Histopathological and capillaroscopical features of the cuticles and bleeding clots in ring or middle fingers of systemic scleroderma patients

Maeda, Manabu; Matubara, Katutoshi; Kachi, Hideki; Mori, Shunji; Kitajima, Yasuo

doi:10.1016/0923-1811(95)93712-a

Cited by 5 publications

(6 citation statements)

References 15 publications

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“…Although the cuticle’s principle function is to serve as a sealant, investigators have also utilized the cuticle for evaluating capillary microcirculation [6], for performing genetic studies [7], and for aiding in the diagnosis of autoimmune connective tissue diseases [8-9]. Researchers developed a technique to evaluate the microcirculation in humans by measuring the pressure of the capillaries in the cuticles of the fourth finger.…”

Section: Discussionmentioning

confidence: 99%

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Curling Cuticles of the Great Toenails: A Case Report of Eponychogryphosis

Cohen¹

2019

Cureus

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The cuticle, also referred to as the eponychium, creates a seal between the proximal nail fold and the nail plate. It is derived from both the ventral and dorsal portions of the proximal nail fold. In addition to its principle function as a barrier preventing allergens, irritants and pathogens from entering the nail cul-de-sac, the cuticle can play a role as a model for evaluating the etiology and management of diseases that affect capillary microcirculation, provide a source of solid tissue for genetic disorder studies, and aid in the evaluation of patients in whom the diagnoses of either systemic scleroderma or dermatomyositis is being entertained. Curling cuticle is a distinctive and unique occurrence. The clinical features of a man with curling cuticles on the lateral portion of both great toes is described. Although a deficiency in personal hygiene may partially account for the clinical finding, the pathogenesis of this observation remains to be established. The term ‘eponychogryphosis’ is proposed to describe the alteration of the patient’s cuticles.

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Section: Discussionmentioning

confidence: 99%

“…Both of these conditions (during the acute phase of disease activity) have characteristic nail fold findings. These include dilated capillaries, cuticular (eponychial) hemosiderin-containing deposits (CEHD), and microhemorrhages that can be readily visualized using a ten-fold magnification dermoscopy [8-9].…”

Section: Discussionmentioning

confidence: 99%

Curling Cuticles of the Great Toenails: A Case Report of Eponychogryphosis

Cohen¹

2019

Cureus

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“…tosen des Nagelhäutchens können auftreten [4,5,7]. Von Interesse sind Beobachtungen, daß die beschriebenen Nagelerscheinungen bei Besserung der Dermatomyositis verschwinden und bei Rezidiven erneut auftreten [5].…”

Section: Das "Keining-zeichen" Bei Dermatomyositisunclassified

Das „Keining-Zeichen” bei Dermatomyositis

Kunte

Plewig

1998

Der Hautarzt

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“…Systemic scleroderma (SSc) is a collagen disease involving the skin and possibly the internal organs such as the heart, lungs, esophagus, and kidneys (1). There are many clinical features indicating SSc such as Raynaud's phenomenon, pitting scars, contracture, sclerodactylia, shortened frenulum of tongue, periungual erythema with elongation and/or hemorrhage in the cuticles distal to the proximal nailfolds, etc (2‐4). They are of help in differentiating SSc from other collagen diseases (4).…”

Section: Introductionmentioning

confidence: 99%

“…There are many clinical features indicating SSc such as Raynaud's phenomenon, pitting scars, contracture, sclerodactylia, shortened frenulum of tongue, periungual erythema with elongation and/or hemorrhage in the cuticles distal to the proximal nailfolds, etc (2‐4). They are of help in differentiating SSc from other collagen diseases (4). Recently, surfactant protein (SP) A and SP‐D, collagenous glycoproteins with multiple functions in the lung (5), have been useful biomarkers for intestitial lung disease in patients with SSc (6).…”

Section: Introductionmentioning

confidence: 99%

Surfactant Protein D (SP‐D) and Systemic Scleroderma (SSc)

Maeda

Ichiki

Aoyama

et al. 2001

The Journal of Dermatology

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We measured serum levels of SP-D in collagen diseases (110 cases) such as systemic scleroderma (SSc), scleroderma spectrum disorders (SSD), systemic lupus erythematodes (SLE), Sjogren syndrome (Sjs), dermatomyositis (DM), rheumatoid arthritis (RA), and dermatitis (DE) (109 cases) as a control. Additionally, we performad a correlation analysis to determine how these levels were related to pulmonary fibrosis and function test (vital capacity, %DLco). The serum levels of SP-D increased in SSc patients with Barnett type III more than in SSc patients with Barnett type I or II, while they increased slightly in SSD (incomplete type of SSc) patients. The differences in these figures were statistically significant between the SSc (SSc & SSD) and non-SSc (SLE, DM, Sjs & RA) groups (p<0.005). The serum levels of SP-D in SSc patients with anti-topoisomerase I antibodies were statistically higher than those in SSc patients with other types of anti-nuclear antibodies. There was a statistically significant correlation between the severity of pulmonary fibrosis and the serum levels of SP-D, and a statistically negative correlation between SP-D levels and vital capacity or %DLco, but there was no proportional correlation with the forced expiatory volume (FEV1.0%). There was no statistical relationship between pre- and post-therapy with photopheresis; however, there was a statistical correlation between the serum levels of SPD and KL-6. In the group of collagen diseases, plasma levels of SP-D were higher than serum levels of SP-D. Patients with SSc possess higher levels of SP-D than do those with other collagen diseases and dermatitis, which may correspond to the severity of pulmonary fibrosis.

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Histopathological and capillaroscopical features of the cuticles and bleeding clots in ring or middle fingers of systemic scleroderma patients

Cited by 5 publications

References 15 publications

Curling Cuticles of the Great Toenails: A Case Report of Eponychogryphosis

Curling Cuticles of the Great Toenails: A Case Report of Eponychogryphosis

Das „Keining-Zeichen” bei Dermatomyositis

Surfactant Protein D (SP‐D) and Systemic Scleroderma (SSc)

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