Histopathological alterations in the prostates of Mongolian gerbils exposed to a high-fat diet and di-n-butyl phthalate individually or in combination

Postnatal development of Mongolian gerbil female prostate: An immunohistochemical and 3D modeling study

“…Because of the low occurrence of prostate in female rats and mice, there is a substantial knowledge gap in this subject (Thomson et al, 2002). The Mongolian gerbil is a promising experimental model to study the female prostate because females have a large amount of prostate and this rodents are easy to breed and * (Jesus et al, 2015;Sanches et al, 2014). The description of the main events in the development of the prostate in female Mongolian gerbils generates an important comparative parameter for studies evaluating hormone manipulation, development disruptions, and the susceptibility to prostatic diseases; topics that have been under intense scrutiny recently (Jesus et al, 2015;Perez et al, 2011Perez et al, , 2012Zanatelli et al, 2014).…”

The Expression of the Androgen Receptor and Estrogen Receptor 1 is Related to Sex Dimorphism in the Gerbil Prostate Development

“…In view of this practical limitation, the female Mongolian gerbil, which has a large functional prostate, constitutes a promising experimental model for research on the female gland. Moreover, breeding and handling of this strain are an easy task in the laboratory setting (Santos and Taboga, ; Sanches et al, , 2015; Jesus et al, ).…”

“…The difficulties and ethical issues associated with the study of the woman prostate (Zaviačič, 1999;Zaviačič et al, 2000) make the gerbil an excellent model to examine prostatic pathologies that resemble those in humans . Also, the investigation of the underlying molecular mechanisms could help us to understand the sexual variations in the development of prostatic pathologies that result from the exposure to endocrine disruptors and steroids Perez et al, 2011Perez et al, , 2012, or from lifestyle habits (Jesus et al, 2015).…”

Differential ontogenetic exposure to obesogenic environment induces hyperproliferative status and nuclear receptors imbalance in the rat prostate at adulthood

“…Prostate development is directly influenced by hormonal milieu [16][17][18][19] which makes this gland a potential target for gestational or perinatal alterations involving sex steroid hormones. There is wide evidence that an alteration in sex steroid signaling induced by exposure to androgen, estrogen, or endocrine-disrupting chemicals (EDC) in intra-uterine and neonatal life may impact prostate development and alter the susceptibility to prostate disease later in life [20][21][22][23][24][25]. However, the consequences of altered intra-uterine nutrition on prostate maturation and health remain elusive, particularly as regards excessive dietary fat [12][13][14][15].…”