Histopathologic Study of the Human Eustachian Tube and Its Surrounding Structures Following Irradiation for Carcinoma of the Oropharynx

Abstract

This is the first histopathologic report, to our knowledge, demonstrating the effects on the ET lumen and supporting structures following acute weight loss, possible tumor infiltration, and radiation changes for carcinoma of the oropharynx.

Studies in Otitis Media: Children's Hospital Of Pittsburgh–University of Pittsburgh Progress Report—2004

“…Other contributions from Sando's laboratory were related to the pathological changes of the eustachian tube‐middle ear in individuals with cleft palate and high arched palate, 45 Down syndrome, 41 congenital syndromes, 46,47 chromosomal abnormalities, 48,49 advanced malignant tumors of the head and neck with involvement of the paratubal structures, 22 carcinoma of the oropharynx, 50 lymphoma invading the tensor veli palatini muscle implicating functional obstruction, 51 chronic renal failure, 52 and the occurrence of mucosa‐associated lymphoid tissue in the middle ear and the eustachian tube, possibly related to otitis media 53 …”

2. Eustachian Tube, Middle Ear, and Mastoid Anatomy; Physiology, Pathophysiology, and Pathogenesis

“…Cheng et al 24 reported the long-term follow-up of 21 patients following irradiation for nasopharyngeal carcinoma and demonstrated that the tube is usually patulous, as assessed by sonotubometry or inflation-deflation tests, but that in time the tympanic membrane became normallikely because of the patulous tube. Takasaki et al 25 described the effect of irradiation of the oropharynx on the human ET from histopathologic assessment of temporal bones and reported that the tubal lumen was patulous and wider, and that Ostmann's fatty tissue, the levator veli palatini muscle, and submucosal glands around the tubal cartilage were replaced by denser connective tissue than in control cases. In another study, Young and Lu 26 reported that according to a 10-year follow-up of patients who had been irradiated for nasopharyngeal carcinoma, hearing can be preserved if ME inflammation can be controlled and advised against routine insertion of tympanostomy tubes for recurrent and chronic otorrhea.…”

The Analysis of Late-Term Otologic Complications Secondary to Treatment and Treatment Methods of Complications in Patients with Nasopharyngeal Cancer

“…3,7 Östaki tüpünün geç fibrozisi, farengeal orifiste veya mukozal atrofi sonucu patent tuba östaki de gelişebilir. 8 Bu çalışmada; en sık muayene bulgusu olarak 41 (%33,6) orta kulak normal olarak değerlendirildi. Patolojilerde en sık adeziv otitis media (n=31, %25,4); sonra sırasıyla valsalva ile düzelen östaki tüp disfonksiyonu (n=30, %24,6), miringoskleroz (n=29, %23,8), SOM (n=11, %9,0), mukozal kronik otitis media (n=2, %1,6) izlendi.…”