Histopathologic risk factors in retinoblastoma: A retrospective study of 172 patients treated in a single institution

Abstract

In our experience, retrolaminar optic nerve involvement, with free resection line, and massive choroidal invasion significantly increase the risk for orbital and/or metastatic disease.

Diagnosis and current management of retinoblastoma

“…Massive choroidal invasion is generally considered the only other risk factor, the association of optic nerve and choroidal invasion carrying the greatest risk (Shields et al, 1993a;Khelfaoui et al, 1996;Chantada et al, 1999).…”

Iodine-125 Orbital Brachytherapy with a Prosthetic Implant In Situ

“…As we now know which tumors are likely to recur in the orbit on the basis of the histological assessment of the enucleated eye, those at risk can be treated with radiotherapy and/ or chemotherapy adjunctively to minimize the risk [7,11,12,14,19,20]. Brachytherapy is a very good approach to irradiate small volumes precisely [15,22].…”

Retinoblastoma

“…Une classification internationale inté grant l'extension locoré gionale et à distance a é té publié e ré cemment [8]. extraoculaires, est dé battue, fondé e sur les ré sultats de l'analyse histopathologique de la piè ce d'é nuclé ation [9,21,23,39,44]. Plusieurs associations de mé dicaments de chimiothé rapie sont utilisé es : carboplatine-é toposide, vincristine-cyclophosphamide AE doxorubicine.…”