Histopathologic findings in the sacrocaudalis dorsalis medialis muscle of horses with vitamin E–responsive muscle atrophy and weakness

Bedford, Holly E.; Valberg, Stephanie J.; Firshman, Anna M.; Lucio, M.; Boyce, M.; Trumble, Troy N.

doi:10.2460/javma.242.8.1127

Cited by 24 publications

(21 citation statements)

References 34 publications

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“…This is consistent with a diagnosis of EMND as approximately 40% of horses will respond to α‐TP supplementation . A further differential diagnosis for EMND would have been a vitE ‐deficient myopathy; however, this would have required a muscle biopsy for diagnosis and may be a prodromal stage of EMND . For the remaining horses, the owner elected to lease pasture in order to provide a source of natural vitE.…”

Section: Discussionsupporting

confidence: 64%

Pigment retinopathy in warmblood horses with equine degenerative myeloencephalopathy and equine motor neuron disease

Finno

Kaese

Miller

et al. 2016

Veterinary Ophthalmology

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Objective A pigment retinopathy has been reported in adult horses with equine motor neuron disease (EMND) arising from chronic α-tocopherol (α-TP) deficiency. A pigment retinopathy has not been identified in horses with neuroaxonal dystrophy/equine degenerative myeloencephalopathy (NAD/EDM) that affects genetically susceptible young horses with α-TP deficiency. The objective of this report is to describe, for the first time, a pigment retinopathy in a family of α-TP-deficient Warmbloods (WB) with clinically apparent NAD/EDM or EMND. Animals and Procedures Twenty-five WB horses from one farm underwent complete neurologic and ophthalmic examinations and serum α-TP concentrations were assessed. Two of the most severely ataxic horses were euthanized and postmortem examinations performed. Results Alpha-TP deficiency was widespread on this farm (22 of 25 horses). Eleven of 25 horses were clinically normal (age range 2–12 years), one had signs of EMND (6 years of age), 10 had signs of ataxia consistent with NAD/EDM (1–10 years), and two of these were postmortem confirmed concurrent NAD/EDM and EMND. A pigment retinopathy characterized by varying amounts of granular dark pigment in the tapetal retina was observed in four clinically apparent NAD/EDM horses (two postmortem confirmed concurrent NAD/EDM and EMND) and one horse with clinical signs of EMND. Conclusions A pigment retinopathy can be present in young α-TP-deficient Warmblood horses with clinical signs of EMND as well as those with signs of NAD/EDM.

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Section: Discussionsupporting

confidence: 64%

Pigment retinopathy in warmblood horses with equine degenerative myeloencephalopathy and equine motor neuron disease

Finno

Kaese

Miller

et al. 2016

Veterinary Ophthalmology

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“…Vitamin E has antioxidant properties and stabilizes cell membranes, in particular myocytes [16], against oxidative damage, which is a cause of muscle degeneration in many neuromuscular diseases [17]. Malnutrition-derived dystrophy or muscle atrophy are known in animals [18]. Some trials with vitamin E in the 1990’s, however, did not show a beneficial effect on human muscular dystrophy [19].…”

Section: Discussionmentioning

confidence: 99%

Improving Reproducibility of Phenotypic Assessments in the DyW Mouse Model of Laminin-α2 Related Congenital Muscular Dystrophy

Willmann

Gordish‐Dressman

Meinen

et al. 2017

JND

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Laminin-α2 related Congenital Muscular Dystrophy (LAMA2-CMD) is a progressive muscle disease caused by partial or complete deficiency of laminin-211, a skeletal muscle extracellular matrix protein. In the last decade, basic science research has queried underlying disease mechanisms in existing LAMA2-CMD murine models and identified possible clinical targets and pharmacological interventions. Experimental rigor in preclinical studies is critical to efficiently and accurately quantify both negative and positive results, degree of efficiency of potential therapeutics and determine whether to move a compound forward for additional preclinical testing. In this review, we compare published available data measured to assess three common parameters in the widely used mouse model DyW, that mimics LAMA2-CMD, we quantify variability and analyse its possible sources. Finally, on the basis of this analysis, we suggest standard set of assessments and the use of available standardized protocols, to reduce variability of outcomes in the future and to improve the value of preclinical research.

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“…In Quarter Horses and related breeds it appears there is a second mutation, malignant hyperthermia, that potentially worsens the signs of PSSM in affected horses. 718 Horses affected with myopathy related to vitamin E deficiency may present with signs of muscle atrophy, weakness, toe dragging, and muscle fasciculations, as well as poor performance. Recurrent exertional rhabdomyolysis (RER) is a heritable abnormality of intramuscular calcium regulation seen primarily in Thoroughbreds and to a lesser extent in Standardbreds and possibly Arabians.…”

Section: Locomotor Disordersmentioning

confidence: 99%

Clinical Approach to Commonly Encountered Problems

Hines¹

2018

Equine Internal Medicine

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Histopathologic findings in the sacrocaudalis dorsalis medialis muscle of horses with vitamin E–responsive muscle atrophy and weakness

Cited by 24 publications

References 34 publications

Pigment retinopathy in warmblood horses with equine degenerative myeloencephalopathy and equine motor neuron disease

Pigment retinopathy in warmblood horses with equine degenerative myeloencephalopathy and equine motor neuron disease

Improving Reproducibility of Phenotypic Assessments in the DyW Mouse Model of Laminin-α2 Related Congenital Muscular Dystrophy

Clinical Approach to Commonly Encountered Problems

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