Histopathologic Evaluation of Hyaluronic Acid and Plasma-Rich Platelet Injection into Rabbit Vocal Cords: An Experimental Study

Özgürsoy, Selmin Karataylı; Tunçkaşık, Fatma; Tunçkaşık, M Emin; Akincioglu, Egemen; Doğan, Handan; Beriat, Güçlü Kaan

doi:10.5152/tao.2018.2942

Cited by 12 publications

(6 citation statements)

References 27 publications

(30 reference statements)

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“…PRP is a biological material shown to stimulate host tissue rejuvenation without eliciting immune rejection as it is derived from the patient's own blood. The composition of PRP consists primarily of a high concentration of platelets and growth factors but can also include white blood cells and other vasoactive and chemotactic agents 29 . PRP releases growth factors that expedite wound healing via cell proliferation, matrix formation, osteoid production, connective tissue healing, angiogenesis, and collagen synthesis 30,31 .…”

Section: Discussionmentioning

confidence: 99%

“…PRP injections have been shown to have a broad range of applications in tissue sealing, stabilization, scar maturation, osteogenesis, and alopecia across various surgical specialties from orthopedics to cosmetic surgery with virtually no adverse side effects 32–34 . In vivo studies revealed the effect of PRP in vocal fold healing in rabbit models following acute vocal fold injury 29 . In otolaryngology, the wound healing properties of PRP have previously been used to treat tympanic membrane perforation 35 .…”

Section: Discussionmentioning

confidence: 99%

“…[32][33][34] In vivo studies revealed the effect of PRP in vocal fold healing in rabbit models following acute vocal fold injury. 29 In otolaryngology, the wound healing properties of PRP have previously been used to treat tympanic membrane perforation. 35 This prospective clinical report on the use of PRP in the human larynx is unique and builds on recent interest in commissioning bioactive components, including fibroblast growth factors and autologous bone marrow-derived mesenchymal stromal cells, to treat pathologies of the head and neck.…”

Section: Discussionmentioning

confidence: 99%

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Safety of Platelet‐Rich Plasma Subepithelial Infusion for Vocal Fold Scar, Sulcus, and Atrophy

et al. 2022

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Objective To demonstrate the safety profile of platelet‐rich plasma (PRP) as an injectable therapeutic for the treatment of vocal fold scarring and atrophy. Methods Preliminary report on a prospective clinical trial of patients with vocal fold scar or atrophy undergoing unilateral vocal fold subepithelial infusion with autologous PRP. Enrolled patients underwent four subepithelial injections spaced 1 month apart. Adverse events were assessed peri and post‐injection at each session. Patient‐reported outcomes were collected at every visit using the Voice Handicap Index‐10 (VHI‐10) and Vocal Fatigue Index (VFI) questionnaires. Results Twelve patients underwent unilateral vocal fold injection with autologous PRP prepared according to Eclipse PRP® system protocol. Forty‐three injections were performed using a peroral or percutaneous approach. An average of 1.57 ± 0.4 cc (range 0.6–2.0 cc) injectate was used. All patients tolerated the procedure without difficulty or peri‐procedural complications. The average duration of follow‐up was 3.6 ± 1.8 months. No significant inflammatory reactions or adverse events were seen to date. There was statistically significant improvement in patient‐reported outcomes at the 3 month follow up (n = 9) follow‐up (mean ΔVHI‐10 = 10.8, p < 0.001, mean ΔVFI = 18.9, p = 0.01, t test, paired two sample for means, two‐tail). All nine patients who completed the series of four injections subjectively (yes/no) reported they were satisfied with the results. Conclusion This prospective study cohort demonstrated a favorable safety profile, with no adverse events or peri‐procedural complications. Subjective improvements in vocal quality and reduction in vocal fatigue need to be clinically correlated with further study. Level of Evidence 4 Laryngoscope, 133:647–653, 2023

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Safety of Platelet‐Rich Plasma Subepithelial Infusion for Vocal Fold Scar, Sulcus, and Atrophy

et al. 2022

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“…This trial contributes to further research on PVRP-based treatment for hearing loss ( Stolle et al, 2018 ), facial nerve palsy ( Sánchez et al, 2018 ), dysphonia ( Cobden et al, 2016 ; Özgürsoy et al, 2018 ), dysphagia ( Vidovic and Delling, 2017 ), anosmia ( Yasak et al, 2018 ), soft-tissue defects ( Eryılmaz et al, 2016 ; Tambella et al, 2018 ), or laryngotracheal reconstruction ( Sahin Onder et al, 2020 ). In addition, sterile PVRP could be administered to the sterile human body areas.…”

Section: Discussionmentioning

confidence: 99%

Autologous Platelet- and Extracellular Vesicle-Rich Plasma Is an Effective Treatment Modality for Chronic Postoperative Temporal Bone Cavity Inflammation: Randomized Controlled Clinical Trial

Vozel

Božič

Jeran

et al. 2021

Front. Bioeng. Biotechnol.

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PurposeTo determine the efficacy of autologous platelet- and extracellular vesicle-rich plasma (PVRP) to treat chronic postoperative temporal bone cavity inflammation (CPTBCI) after exhausting surgical and standard conservative therapies.Materials and MethodsPatients were randomly allocated to treatment with PVRP (PVRP group) or standard conservative methods (control group) in a setting of four once-monthly checkups and subsequent follow-up. The treatment outcome was measured with the Chronic Otitis Media Questionnaire-12 (COMQ-12), CPTBCI focus surface area, and CPTBCI symptom-free time after the fourth checkup.ResultsEleven patients from each group completed the trial; 95% of patients suffered from chronically discharging mastoid cavity (the type of CPTBCI). Within four checkups, the COMQ-12 score decreased statistically significantly in the PVRP group (p < 0.001) but not in the control group (p = 0.339). The CPTBCI foci surface area decreased statistically significantly between the first and second checkups (p < 0.0005) but not between other checkups (p > 0.05) in the PVRP group. No statistically significant differences in CPTBCI foci surface area were detected between checkups in the control group (p = 0.152). Nine patients from the PVRP group and three patients from the control group were CPTBCI symptom-free at the fourth checkup. The median symptom-free time was 9.2 months (95% CI [7.4, 11.9]) in the PVRP group. Cumulatively, 49% of patients in the PVRP group remained CPTBCI symptom-free for 12.7 months after the fourth checkup.ConclusionAutologous PVRP represents a novel additional and successful treatment modality for a chronically discharging radical mastoid cavity when the surgical and standard conservative treatment methods have been exhausted.Trial Numberhttps://clinicaltrials.gov (NCT04281901).

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“…A few animal studies have reported favorable results in vocal fold healing using PRP following acute vocal fold injury [ 11 , 12 , 13 ]. To the best of our knowledge, there are currently no human studies regarding the effect of PRP on voice outcomes following phonosurgery.…”

Section: Introductionmentioning

confidence: 99%

The Effect of Platelet-Rich Plasma Injection on Short Term Vocal Outcomes Following Phonosurgery—A Pilot Study

et al. 2022

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Background and Objectives: The efficiency and optimal voice rest period following phonosurgery remains debatable. Platelet-rich plasma (PRP) is a safe and cheap alternative to many bioactive agents being studied on animal models, and is already in use in many medical areas. We investigate the short-term effects of PRP and voice rest on voice outcomes following phonosurgery as an alternative to voice rest alone. Materials and Methods: A prospective single-blinded pilot study was conducted. Sixteen patients with a diagnosis of vocal fold cyst and polyps were included, forming equal groups (PRP and voice rest vs. voice rest alone). Voice analysis was carried out on the preoperative day, day three, and week three following surgery. The measured parameters were fundamental frequency (F0), noise–signal ratio (NSR), harmonic poverty (HP), attack alteration (AL), pitch instability (PI), and amplitude instability (AI).VHI(Voice Handicap Index)-30 questionnaires were carried out before surgery and three weeks following surgery to assess the impact of subjective voice change on quality of life. PRP was obtained using commercial kits with separator gel. Results: An average 3.68-fold increase in platelets was obtained with PRP. No side effects were noted after injection. All voice parameters improved on day three and week three following surgery. Statistical significance was noted only in the fundamental frequency of male patients (p = 0.048) in favor of the PRP-voice rest group. In addition, the VHI- 30 questionnaire results between preoperative and postoperative assessments showed statistically significant differences in total VHI score (p = 0.02) as well as the physical (p = 0.05) and emotional (p = 0.02) scale in favor of the PRP-voice rest group. Conclusions: PRP presents short term safety in patients who undergo phonosurgery, although long-term outcomes are unknown. PRP and voice rest are superior to voice rest alone when considering subjective assessment of the voice. When analyzing acoustic parameters, PRP and voice rest are not superior to voice rest alone.

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Histopathologic Evaluation of Hyaluronic Acid and Plasma-Rich Platelet Injection into Rabbit Vocal Cords: An Experimental Study

Cited by 12 publications

References 27 publications

Safety of Platelet‐Rich Plasma Subepithelial Infusion for Vocal Fold Scar, Sulcus, and Atrophy

Safety of Platelet‐Rich Plasma Subepithelial Infusion for Vocal Fold Scar, Sulcus, and Atrophy

Autologous Platelet- and Extracellular Vesicle-Rich Plasma Is an Effective Treatment Modality for Chronic Postoperative Temporal Bone Cavity Inflammation: Randomized Controlled Clinical Trial

The Effect of Platelet-Rich Plasma Injection on Short Term Vocal Outcomes Following Phonosurgery—A Pilot Study

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