Histopathologic effects of Stachytarpheta jamaicensis (L.)Vahl. on Wistar rats

., J.E. Ataman; Idu, MacDonald; Odia, E. A.; Omogbai, Eric K. I.; ., F. Amaechina; Akhigbe, AO; ., L.E. Ebite

doi:10.1055/s-2006-949893

Cited by 4 publications

(6 citation statements)

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“…In herbal medicine, S. jamaicensis itself has been known to demonstrate analgesic, 8 anti-inflammatory, 9 antihelminthic, 10 diuretic, laxative, lactagogue, purgative, sedative, spasmogenic, vasodilator, vulnerary, and vermifuge properties 11 and claims of blood sugar lowering effect by some traditional healers. 12 This study, therefore, investigated the hypoglycaemic effect viz-aviz the antidiabetic property of S. jamaicensis leaves.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the Antioxidant and Hypoglycaemic Potentials of the Leaf Extracts of Stachytarphyta jamaicensis (Verbenaceae)

Egharevba¹,

Chukwuemeke-Nwani²,

Eboh³

et al. 2019

TJNPR

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Stachytarpheta jamaicensis (family Verbanaceae) commonly known as blue porterweed is widely used in folk medicine for the treatment of various diseases including diabetes mellitus. The present study investigated the blood glucose lowering effect and the antioxidant activity of the leaf extracts of Stachytarpheta jamaicensis. The phytochemical screening of the powdered leaf sample was done according to standard procedures. The antioxidant activity of the methanol and ethyl acetate extracts of the leaves were investigated using the 1,1-diphenyl-2-picrylhydrazine (DPPH) radical scavenging assay, the total phenolic and flavonoid contents were also evaluated following standard procedures. The hypoglycaemic effect of the extracts was evaluated using streptozotocin-induced diabetes in rats. Phytochemical screening shows the presence of carbohydrates, alkaloids, saponins, tannins, phenolic compounds, and flavonoids. The extracts demonstrated appreciable and concentration-dependent radical scavenging effect with IC50 values of 16.95 µg/mL and 33.12 µg/mL, for the methanol extract and ethyl acetate extract, respectively. Oral administration of the extracts at 200 mg/kg and 400 mg/kg daily dose significant lowers blood glucose levels in streptozotocin-induced diabetes in experimental rats compared to the control group (untreated diabetic animals). The present findings have therefore shown that S. jamaicensis leaves has hypoglycaemic and antioxidant effects and may therefore serve as a potential source of hypoglycaemic agent as well as antioxidant agents for the prevention and management of free radical induced metabolic diseases.

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Section: Introductionmentioning

confidence: 99%

Evaluation of the Antioxidant and Hypoglycaemic Potentials of the Leaf Extracts of Stachytarphyta jamaicensis (Verbenaceae)

Egharevba¹,

Chukwuemeke-Nwani²,

Eboh³

et al. 2019

TJNPR

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“…Known locally to the Malays as 'selasih dandi', S. jamaicensis is also used as a remedy for pain and in Sabah, Malaysia, the entire plant is boiled and the decoction applied to treat sprains [5] . The leaves of S. jamaicensis have also been used in some Nigerian communities for treating ailments such as diabetes, hypertension and bacterial infections [6] .…”

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confidence: 99%

“…S. cayennensis leaves have also been reported to exhibit anti-inflammatory and antinociceptive activities elicited by two compounds, iridoid ipolamiide and acetoside, isolated from the leaves of the plant [10] . S. jamaicensis [6] has also been found to cause mild non-dose-dependent systemic activity in some specific tissues (liver, kidney, lung and testis) with no effects seen in the brain, eyes, intestine and heart tissues. S. jamaicensis extracts have also been demonstrated to cause toxicity to the Aedes aegypti mosquito [11] .…”

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confidence: 99%

Antinociceptive and Anti-Inflammatory Effects of <i>Stachytarpheta jamaicensis </i>(L.) Vahl (Verbenaceae)in Experimental Animal Models

Sulaiman

Zunita²,

Chiong³

et al. 2009

Med Princ Pract

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Objective: The present study was carried out to explore the antinociceptive as well as the anti-inflammatory effects of an ethanol extract of Stachytarpheta jamaicensis (L.) Vahl (EESJ) using 3 models of nociception and 2 models of inflammation in experimental animals. Materials and Methods: EESJ was prepared by overnight soaking of the oven-dried (50°C; 72 h) ground leaves (500 g) in 80% ethanol (1:5; w/v). The filtrate was evaporated to dryness (50°C), resuspended in distilled water at concentrations to provide the desired doses of 50, 100 and 150 mg/kg. For antinociceptive effects, 3 models were used: acetic acid-induced abdominal writhing, hot-plate- and formalin-induced paw-licking tests; for anti-inflammatory effects, 2 models were used – carrageenan-induced paw edema and cotton-pellet-induced granuloma tests. Appropriate doses were administered intraperitoneally (i.p.) to mice/rats prior to each test. The mechanisms of antinociceptive action of the extract were also investigated by pretreatment with naloxone (5 mg/kg, i.p.). Results: The extract exhibited significant (p < 0.05) antinociceptive activity in all nociceptive models tested with dose-dependent activity observed using the abdominal writhing and formalin tests. Pretreatment with naloxone partially, but significantly (p < 0.05) reversed the antinociceptive activity of the extract when assessed using the abdominal-writhing- and formalin-induced paw-licking tests, and completely inhibited its activity when the hot-plate test was used. The extract also showed significant (p < 0.05) anti-inflammatory activity in both the acute (carrageenan-induced paw edema test) and the chronic (cotton-pellet granuloma test) tests. Conclusion: This study showed the potential of EESJ to exert antinociceptive and anti-inflammatory activities, the former being modulated via peripheral and central mechanisms and involving, in part, activation of the opioid receptor system.

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“…30 It was thus important to investigate the effect of A. difformis on the function of these organs. Although, 9 reported that A. difformis used to handle different ailments is toxic to the renal tissue at a dose-dependent level, acute treatment of rats with 10,000 mg/kg in this study did not cause death or any toxicological manifestations in the rats ( Table 1).…”

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confidence: 57%

“…7 It is sometimes called forest anchomanes in English, 8 Ogiriisako or Oje (Igbo language), Langbodo or Isu-igo in Yoruba language, Chakara in Hausa language, and ebe-olikhoro in bini language. 9 An in vitro study of the antimicrobial activities of A. difformis leaves and rhizomes against selected pathogens of public health importance showed that most pathogens of public health importance were susceptible to both extracts showing that A. difformis has got antimicrobial activity. In parts of Africa such as Tanzania, the juice from the root tuber is used in the treating river blindness.…”

mentioning

confidence: 99%

Toxicological studies of Anchomanes difformis Blume (Araceae) using rats and mice

Oghale

Idu

Eze

et al. 2015

Int J Basic Clin Pharmacol

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Histopathologic effects of Stachytarpheta jamaicensis (L.)Vahl. on Wistar rats

Cited by 4 publications

References 0 publications

Evaluation of the Antioxidant and Hypoglycaemic Potentials of the Leaf Extracts of Stachytarphyta jamaicensis (Verbenaceae)

Evaluation of the Antioxidant and Hypoglycaemic Potentials of the Leaf Extracts of Stachytarphyta jamaicensis (Verbenaceae)

Antinociceptive and Anti-Inflammatory Effects of <i>Stachytarpheta jamaicensis </i>(L.) Vahl (Verbenaceae)in Experimental Animal Models

Toxicological studies of Anchomanes difformis Blume (Araceae) using rats and mice

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