Histopathologic Effects of Stachytarpheta jamaicensis (L.) Vahl. on Wistar Rats

., J.E. Ataman; Idu, MacDonald; Odia, E. A.; Omogbai, Eric K. I.; ., F. Amaechina; Akhigbe, AO; ., L.E. Ebite

doi:10.3923/pjbs.2006.477.482

Cited by 8 publications

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“…Moreover, ultrasound picture of heart, liver, kidney, and spleen also showed no significant difference from control [45]. However, Ataman et al [46] reported that rats were fed with the same dose and concentration as in Idu et al [45] showed slight variation on the physical signs/body appearance of the animals and mild histopathologic lesions such as congestion, fatty changes, and necrosis were found in certain tissues, such as liver, blood vessels, kidney, lung, and testis. On the other hand, the brain, eyes, small and large intestines, and heart tissues were essentially normal.…”

Section: Toxicology Studies Of S Jamaicensismentioning

confidence: 99%

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Stachytarpheta jamaicensis (L.) Vahl: From Traditional Usage to Pharmacological Evidence

Liew

Yong

2016

Evidence-Based Complementary and Alternative Medicine

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Introduction. Stachytarpheta jamaicensis (L.) Vahl belongs to the family of Verbenaceae and is commonly known as Gervao, Brazilian tea, verbena cimarrona, rooter comb, or blue porter weed. It is one of the important plants with high medicinal and nutraceutical benefits. S. jamaicensis contains various medicinal properties in traditional and folk medicinal systems, with cures for several diseases. Objective. The objective of this review paper is to collect information concerning the morphology, distribution, traditional usage, phytochemical compositions, biological activities, and safety data of S. jamaicensis. Materials and Methods. The information was obtained from literature search through electronic databases such as PubMed and Google Scholar on S. jamaicensis. Results and Conclusion. The high medicinal properties of this plant, for instance, antimicrobial and antifungal effect as the main activities, but verbascoside as the main active chemical component, make it a valuable source of the medicinal compound. This review paper summarizes all information concerning the morphology, distribution, traditional usage, phytochemical compositions, pharmacological activities, and toxicological studies of S. jamaicensis.

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Section: Toxicology Studies Of S Jamaicensismentioning

confidence: 99%

“…On the other hand, the brain, eyes, small and large intestines, and heart tissues were essentially normal. These data suggested that S. jamaicensis seems to cause mild systemic toxicity in certain tissues [46]. Further studies have been conducted by Idu et al [1] on acute toxicity of S. jamaicensis leaves.…”

Section: Toxicology Studies Of S Jamaicensismentioning

confidence: 99%

Stachytarpheta jamaicensis (L.) Vahl: From Traditional Usage to Pharmacological Evidence

Liew

Yong

2016

Evidence-Based Complementary and Alternative Medicine

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“…This observation is in tandem with the cytotoxic effects of high fat diet plus streptozotocin on the pancreas of rats which might have led to β cell damage and consequently hyperglycaemia [47]. Section of the pancreas of the rats treated with various doses of Stachytarpheta jamaicensis extracts revealed marked improvements over the diabetic untreated (Plate 3) [44].…”

Section: Discussionmentioning

confidence: 95%

“…This is supported by the elevation of liver enzymes and lipid profiles of the untreated diabetic rats. Non-alcoholic fatty liver disease is a condition which characterizes poorly controlled diabetes mellitus [44,45].…”

Section: Discussionmentioning

confidence: 99%

Anti-diabetic effect of Stachytarpheta jamaicensis on low dose streptozotocin-induced diabetic rats fed on a high-fat diet

2021

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Introduction This study evaluates the anti-diabetic effect of ethanol extract of Stachytarpheta jamaicensis leaf on streptozotocin (STZ) - induced diabetic rats fed on high-fat diet (HFD). Methods Sets of male albino rats of the Wistar strain weighing between 180 and 250 g were exposed to high fat diet (margarine and oil from vegetable sources in a ratio of 2:1 w/v) for 3 weeks. Then the animals were fasted overnight; hyperglycemic state was induced using reduced dose of streptozotocin (35 mg/kg) and animals were randomly divided into five groups (n = 7); group A received the HFD + STZ (35 mg/kg i.p.); group B received HFD + STZ + gliberclamide (10 mg/kg; i.p); groups C, D and E were administered the HFD + streptozotocin with different doses of the ethanol extract (30, 35 and 100 mg/kg p.o., respectively). Results Results showed significant (p < 0.05) decrease in blood glucose concentration of the rats treated with different doses of S. jamaicensis extract and those treated with gliberclamide compared to the untreated diabetic rats (negative control). Significant (p < 0.05) reductions in activities of serum AST, ALP, total protein and bilirubin were noticed in the groups in contrast to the control. Levels of urea, creatinine, potassium and chloride were considerably (p < 0.05) low while sodium and bicarbonate levels were high in the groups except the control. Lipid profile revealed significant (p < 0.05) reduction in total cholesterol, triacylglycerol, LDL, VLDL while HDL levels were high in the groups compared to the control. The extract significantly (p < 0.05) ameliorated weight loss. Histopathology of the liver, kidney and pancreas showed ameliorative effect of the extract against the deleterious changes occasioned by the HFD and STZ induced diabetic state. Conclusion These findings have provided scientific basis for the use of S. jamaicensis in the treatment of diabetes mellitus in ethnomedicinal practices in Nigeria.

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Antinociceptive and Anti-Inflammatory Effects of <i>Stachytarpheta jamaicensis </i>(L.) Vahl (Verbenaceae)in Experimental Animal Models

Sulaiman

Zunita²,

Chiong³

et al. 2009

Med Princ Pract

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Objective: The present study was carried out to explore the antinociceptive as well as the anti-inflammatory effects of an ethanol extract of Stachytarpheta jamaicensis (L.) Vahl (EESJ) using 3 models of nociception and 2 models of inflammation in experimental animals. Materials and Methods: EESJ was prepared by overnight soaking of the oven-dried (50°C; 72 h) ground leaves (500 g) in 80% ethanol (1:5; w/v). The filtrate was evaporated to dryness (50°C), resuspended in distilled water at concentrations to provide the desired doses of 50, 100 and 150 mg/kg. For antinociceptive effects, 3 models were used: acetic acid-induced abdominal writhing, hot-plate- and formalin-induced paw-licking tests; for anti-inflammatory effects, 2 models were used – carrageenan-induced paw edema and cotton-pellet-induced granuloma tests. Appropriate doses were administered intraperitoneally (i.p.) to mice/rats prior to each test. The mechanisms of antinociceptive action of the extract were also investigated by pretreatment with naloxone (5 mg/kg, i.p.). Results: The extract exhibited significant (p < 0.05) antinociceptive activity in all nociceptive models tested with dose-dependent activity observed using the abdominal writhing and formalin tests. Pretreatment with naloxone partially, but significantly (p < 0.05) reversed the antinociceptive activity of the extract when assessed using the abdominal-writhing- and formalin-induced paw-licking tests, and completely inhibited its activity when the hot-plate test was used. The extract also showed significant (p < 0.05) anti-inflammatory activity in both the acute (carrageenan-induced paw edema test) and the chronic (cotton-pellet granuloma test) tests. Conclusion: This study showed the potential of EESJ to exert antinociceptive and anti-inflammatory activities, the former being modulated via peripheral and central mechanisms and involving, in part, activation of the opioid receptor system.

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Histopathologic Effects of Stachytarpheta jamaicensis (L.) Vahl. on Wistar Rats

Cited by 8 publications

References 0 publications

Stachytarpheta jamaicensis (L.) Vahl: From Traditional Usage to Pharmacological Evidence

Stachytarpheta jamaicensis (L.) Vahl: From Traditional Usage to Pharmacological Evidence

Anti-diabetic effect of Stachytarpheta jamaicensis on low dose streptozotocin-induced diabetic rats fed on a high-fat diet

Antinociceptive and Anti-Inflammatory Effects of <i>Stachytarpheta jamaicensis </i>(L.) Vahl (Verbenaceae)in Experimental Animal Models

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