Histopathologic Correlation of Lesions of Papular Urticaria and Positive Skin Test Reactions to Insect Antigens

Shaffer, Bertram; Jacobson, Coleman; Beerman, Herman

doi:10.1001/archderm.1954.01540220039005

Cited by 20 publications

(11 citation statements)

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“…Whenever possible, one should subject to biopsy only newly formed lesions that are not excoriated. 16,40 In a histopathologic study of 30 patients with papular urticaria, T lymphocytes (CD45RO, CD3) and macrophages (CD68) were present in all cases, while B lymphocytes (CD20) and dendritic antigen-presenting cells (S100) were entirely absent. 41 Immunofluorescence staining for the deposition of immunoglobulin (Ig) A, IgG, IgM, C3, and fibrin was negative in all cases.…”

Section: Etiologymentioning

confidence: 98%

“…12 Excruciating pruritus frequently leads to excoriations, which may become secondarily impetiginized. 16,17 The lesions generally persist for 2 to 10 days and may result in temporary hyperpigmentation once they resolve. 5…”

Section: Papular Urticariamentioning

confidence: 99%

“…12 The histologic appearance of papular urticaria was identical to that of the eruptions of persistent insect bite reactions, a finding that lent further credence to the idea that arthropods were the cause of papular urticaria. 16 The primary lesion of papular urticaria is an erythematous wheal, which is followed by the formation of a firm, brownish-red papule. 21 Because papular urticaria is an allergic hypersensitivity reaction to arthropod bites, patients with the condition must be previously sensitized to parasitic antigens.…”

Section: Etiologymentioning

confidence: 99%

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Steen

Carbonaro

Schwartz

2004

Journal of the American Academy of Dermatology

168

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Section: Etiologymentioning

confidence: 98%

Section: Papular Urticariamentioning

confidence: 99%

Section: Etiologymentioning

confidence: 99%

See 1 more Smart Citation

Arthropods in dermatology

Steen

Carbonaro

Schwartz

2004

Journal of the American Academy of Dermatology

168

127

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“…Aunque se describió ya hace dos siglos, su relación con la picadura de insectos no siempre fue evidente. En los años 50, Shaffer, et al, fueron los primeros en describir en sus estudios científicos la relación causal entre la enfermedad y la exposición al agente (1,2).…”

Section: Papular Urticaria: a Review Of Causal Agents In Colombiaunclassified

Papular urticaria: A review of causal agents in Colombia

et al. 2016

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López: análisis bioinformático y datos experimentales inéditos Todos los autores contribuyeron en igual medida a la redacción del manuscrito. La urticaria papular es una enfermedad alérgica causada por la picadura de insectos, la cual predomina en el trópico. El objetivo de esta revisión fue profundizar en sus aspectos epidemiológicos e inmunológicos, particularmente con base en datos publicados en Latinoamérica. Se hizo una revisión no sistemática mediante la búsqueda electrónica de artículos sobre la epidemiología de la urticaria papular, las características entomológicas de los agentes causales y los mecanismos inmunológicos asociados. Según los diversos reportes de centros médicos de Latinoamérica la urticaria papular es frecuente; el único estudio de prevalencia publicado indica que afecta a una cuarta parte de los niños escolares de Bogotá. Hay información sobre la relación causal entre la exposición domiciliaria a la pulga, la pobreza y la urticaria papular en Bogotá, una ciudad representativa de las altitudes andinas. No hay estudios que indaguen directamente sobre los insectos causales en zonas cálidas, aunque se sospecha clínicamente de los mosquitos Aedes aegypti y Culex quinquefasciatus. En cuanto a su patogenia, se destaca la participación de mecanismos celulares que involucran las células colaboradoras Th2, lo cual explica que sea una condición de hipersensibilidad retardada. El papel de la inmunoglobulina E (IgE) en la urticaria papular no está tan claro. Se desconocen los antígenos derivados de los insectos que causan la enfermedad, aunque se plantea que existen moléculas comunes de reacción cruzada entre los insectos, tales como el alérgeno Cte f 2 en la pulga, y sus homólogos en los mosquitos. La urticaria papular es una condición frecuente en Latinoamérica que debe investigarse en profundidad. La caracterización inmunológica de los componentes moleculares que causan esta condición puede resolver interrogantes sobre su etiología y su patogenia. Urticaria papular y sus agentes causales en ColombiaPalabras clave: urticaria; insectos; Aedes; Culex; Ctenocephalides; hipersensibilidad. doi: http://dx.doi.org/10.7705/biomedica.v36i4.3258 Papular urticaria: A review of causal agents in ColombiaPapular urticaria is a chronic allergic reaction induced by insect bites, which is common in the tropics. The objective of this review was to deepen on epidemiological and immunological aspects of this disease, focused on data published in Latin American countries. We conducted a non-systematic review of the literature through electronic search on the epidemiology of papular urticaria, the entomological characteristics of the causative agents and associated immunological mechanisms. Several reports from medical centers suggest that papular urticaria is common in Latin America. Only one epidemiological survey designed to estimate prevalence of papular urticaria has been published, reporting that about a quarter of children under six years of age is affected by this condition in Bogotá. There is evidence on the ca...

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“…It is not inconceivable that they may infest telephone equipment (switch¬ boards) and even air conditioners.2 In 1948In -1954 our group at the University of Pennsylvania related papular urticaria to flea bites and noted benefits from the now more or less outlawed chlorophenothane (DDT) therapy.36 It is not inconceivable that they may infest telephone equipment (switch¬ boards) and even air conditioners.2 In 1948In -1954 our group at the University of Pennsylvania related papular urticaria to flea bites and noted benefits from the now more or less outlawed chlorophenothane (DDT) therapy.36…”

Section: MD Californiamentioning

confidence: 99%

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Histopathologic Correlation of Lesions of Papular Urticaria and Positive Skin Test Reactions to Insect Antigens

Cited by 20 publications

References 9 publications

Arthropods in dermatology

Arthropods in dermatology

Papular urticaria: A review of causal agents in Colombia

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