Histopathologic Correlation in Dermoscopy

In Vivo Confocal Microscopic and Histopathologic Correlations of Dermoscopic Features in 202 Melanocytic Lesions

“…[1][2][3][4] Although some dermoscopic features correspond to histologic findings, a direct and exact correlation is difficult to determine. A step-sectioning procedure 5,6 and micropunch technique 7 were used to correlate accurately dermoscopic features with their histopathologic counterparts. Moreover, horizontal histologic sections can be performed; however, this procedure is limited to selected features because of the risk of interference with the Breslow thickness evaluation.…”

“…Streaks (peripheral structures) were present in 52 cases, 15 of which (8 MMs, 4 nevi, and 3 Spitz or Reed nevi) showed radial streamings, 7 19 (8 MMs, 8 nevi, and 3 Spitz or Reed nevi) peripheral globules, and 18 (11 MMs, 5 nevi, and 2 Spitz or Reed nevi) pseudopods. 24 On RCM, radial streamings consisted of parallel series of elongated junctional thickening-like structures or of lines of interpapillary basal cells projected toward the periphery, separated by narrow elongated darker areas corresponding to dermal papillae.…”

Correlation of Dermoscopic Structures of Melanocytic Lesions to Reflectance Confocal Microscopy

“…[6][7][8][9][10] However, owing to the perpendicular plane in which a pathological specimen is sectioned, as opposed to the horizontal plane of view of dermoscopy, this correlation is hindered by technical limitations. 7 Yadav et al 9 presented the correlation of dermoscopic structures by showing the best available dermoscopic and histopathological photomicrographs, not necessarily from the same case. Subsequently, Soyer et al 6 correlated a small series of case-by-case dermoscopic findings to histopathological features by providing the pathologist with a suture-marked tissue sample, a digital dermoscopic image highlighting the dermoscopic structures of interest, and a corresponding Polaroid image of the gross pathological features of the excised le-sion with marking to guide sectioning.…”

Use of Digital Epiluminescence Microscopy to Help Define the Edge of Lentigo Maligna

“…Many researchers have examined the histopathologic correlation of the dermoscopic structures. [23][24][25][26][27][28][29][30][31] A variety of orientation methods, including orienting sutures and micropunch, were used. It does not seem that DELM was previously used to mark the excisional units.…”