Histopathologic Classification of ANCA-Associated Glomerulonephritis

Berden, Annelies E.; Ferrario, Franco; Hagen, E. Christiaan; Jayne, David; Jennette, J. Charles; Joh, Kensuke; Neumann, Irmgard; Noël, Laure Hélène; Pusey, Charles D.; Waldherr, Rüdiger; Bruijn, Jan A.; Bajema, Ingeborg M.

doi:10.1681/asn.2010050477

Cited by 719 publications

(724 citation statements)

References 32 publications

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“…The classification system was composed of a total of 4 categories (25) ( Table 2). Patients with focal and/or crescentic ANCA-associated glomerulonephritis presented with highly active renal disease, but had a favorable renal outcome (25). Patients with a mixed phenotype had an intermediate renal outcome (25).…”

Section: Discussionmentioning

confidence: 99%

“…Patients with focal and/or crescentic ANCA-associated glomerulonephritis presented with highly active renal disease, but had a favorable renal outcome (25). Patients with a mixed phenotype had an intermediate renal outcome (25). However, sclerotic ANCA-associated glomerulonephritis ran the poorest prognosis, with an increased risk of death in the first year of diagnosis (25).…”

Section: Discussionmentioning

confidence: 99%

“…Patients with a mixed phenotype had an intermediate renal outcome (25). However, sclerotic ANCA-associated glomerulonephritis ran the poorest prognosis, with an increased risk of death in the first year of diagnosis (25). This classification takes into account patients with ANCA-negative pauci-immune crescentic glomerulonephritis.…”

Section: Discussionmentioning

confidence: 99%

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Estrada

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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An Unusual Case of Hematuria

Najem

Sfeir

Estrada

et al. 2014

Arthritis Care & Research

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“…Nierenbiopsien liefern dagegen eine hohe diagnostische Ausbeute mit spezifischen Veränderun-gen (nekrotisierende Glomerulonephritis 85 %, Halbmondbildung 92 %) [2]. Die Ergebnisse der Nierenbiopsie haben zudem einen prognostischen Wert, da aktuell entzündliche (und therapeutische beeinflussbare) Veränderungen von bereits eingetretenen irreversiblen Schäden differenziert werden können, was Einfluss aufdie Wahl derTherapie habenkann [13,75,89,134,136,233,245]. Ebensokönnen Nierenfunktionseinschränkungen durch andere Begleiterkrankungen wie Diabetes mellitus oder arterielle Hypertonie abgegrenzt werden.…”

Section: Diagnostikunclassified

S1 guidelines Diagnostics and treatment of ANCA-associated vasculitis

Schirmer

Moosig²

2017

Z Rheumatol

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“…1 The percentage of normal glomeruli is a powerful predictor, possibly the best predictor of histologic outcomes in the short and long term. 9 Nevertheless, renal disease activity indicators, such as increased serum creatinine and/or presence of hematuria, and the value or worsening of proteinuria and erythrocyte cylinders in urine, have been identified. 10 In short, ANCA antibodies have a central involvement in the pathogenesis of these vasculites, but little is known about their prognostic value at the date of diagnosis and progression in the course of disease.…”

mentioning

confidence: 99%

ANCA-positive vasculitis: Clinical implications of ANCA types and titers

Domingues

Machado

Santos

2016

Rev. Assoc. Med. Bras.

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Introduction: Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis is an autoimmune disease that can affect multiple organs, the kidney being one of the most affected. Apart from the diagnostics value of ANCA, they have also been advocated as biomarkers of the disease activity. Recently, the genetic changes found in polyangiitis associated with serine-protease proteinase 3 (PR3)-ANCA or myeloperoxidase (MPO)-ANCA raised the possibility of immune-pathogenic and therapeutic differences. Objective: To identify differences in the number of relapses, inflammatory markers, outcomes and renal histology related to the types of ANCA. To analyze the implications of ANCA titers in prognosis. Method: A retrospective observational study in a Portuguese tertiary hospital. Results: There were no differences in the progression of renal function, histological pattern and initial treatment with regard to ANCA subtypes. As for the evaluated parameters, there were no significant differences according to the types of ANCA, except for mean CRP values within the normal range, which was 6.3±1.3 mg/L for MPO-ANCA and 12.4±10.14 mg/L for PR3-ANCA (p=0.04). We found that 66.7% of the MPO-ANCA-positive showed no relapses versus 40% in the case of PR3-ANCA-positive. There was no correlation between the ANCA titers at presentation, during remission, and in the last evaluation, and the number of relapses. Conclusion: PR3-ANCA patients have a mean CRP value within the normal range significantly higher than that of MPO-ANCA patients (p=0.04), which seems to reveal greater inflammatory activity in the first.

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Histopathologic Classification of ANCA-Associated Glomerulonephritis

Cited by 719 publications

References 32 publications

An Unusual Case of Hematuria

An Unusual Case of Hematuria

S1 guidelines Diagnostics and treatment of ANCA-associated vasculitis

ANCA-positive vasculitis: Clinical implications of ANCA types and titers

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