Histopathologic characterization of human breast cancer in correlation with estrogen receptor status.A comparison of immunocytochemical and biochemical analysis

Reiner, Angelika; Reiner, G.; Spona, J; Schemper, M.; Holzner, Johann

doi:10.1002/1097-0142(19880315)61:6<1149::aid-cncr2820610615>3.0.co;2-z

Cited by 77 publications

(34 citation statements)

References 18 publications

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“…In addition to histological grade (Elston and Ellis, 1991), Ki-67 LI is also well-known to be a useful prognostic factor in human breast carcinoma (Veronese et al, 1993). Inverse correlations between these factors and ER LI (Reiner et al, 1988;Veronese and Gambacorta, 1991) have been reported. Our present data are consistent with these previous reports, and it is suggested that breast carcinomas positive for 17β-HSD type 1 are relatively well differentiated and maintain some of the normal hormonal regulatory mechanisms that lead to a low proliferation rate.…”

Section: Discussionmentioning

confidence: 99%

17 β -Hydroxysteroid dehydrogenase type 1 and type 2 in human breast carcinoma: a correlation to clinicopathological parameters

et al. 2000

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The expression of 17β-hydroxysteroid dehydrogenase (17β-HSD) type 1 and type 2 was examined immunohistochemically in 111 invasive ductal carcinomas, and correlated with various clinicopathological parameters. This study investigates local regulatory mechanisms of oestrogens in human breast carcinoma. 17β-HSD type 1 was immunolocalized in carcinoma cells of 68 out of 111 invasive ductal carcinoma cases (61.3%). 17β-HSD type 2 immunoreactivity was not detected in all cases examined. A significant inverse correlation was observed between the immunohistochemical expression of 17β-HSD type 1 and histological grade of the carcinoma ( P < 0.02). There was a significant correlation between 17β-HSD type 1 and oestrogen receptor (ER) labelling index (LI) ( P < 0.05). In addition, carcinoma cells expressing immunoreactive 17β-HSD type 1 were frequently positive for ER. 17β-HSD type 1 was also correlated with progesterone receptor (PR) LI ( P < 0.05). There was a significant inverse correlation between 17β-HSD type 1 and Ki-67 LI ( P < 0.0001). No significant correlations were detected between 17β-HSD type 1 and other clinicopathological parameters, including patient age, menopausal status, stage, tumour size, lymph node status and prognosis. This study suggests that 17β-HSD type 1 plays an important role in the regulation of in situ oestradiol production in hormone-dependent breast carcinomas. © 2000 Cancer Research Campaign

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Section: Discussionmentioning

confidence: 99%

17 β -Hydroxysteroid dehydrogenase type 1 and type 2 in human breast carcinoma: a correlation to clinicopathological parameters

et al. 2000

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“…Samples were considered negative for ER and PR if \10% of tumor cells showed expression by IHC staining. As IHC staining for ER and PR was each scored from 0 to 7 in our institution, IHC scores of 0-3 were regarded as negative and scores of 4-7 were regarded as positive [17]. IHC staining for HER2 was scored as 0-3, with scores of 0-2 regarded as negative and a score of 3 regarded as positive.…”

Section: Methodsmentioning

confidence: 99%

Clinical features and course of brain metastases in triple-negative breast cancer: comparison with human epidermal growth factor receptor 2-positive and other type at single institution in Korea

Jang

Lee

Ahn

et al. 2011

Breast Cancer Res Treat

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The incidences and clinical aggressiveness of intracranial metastases have not been as well characterized in patients with triple-negative (TN) breast cancer as in patients with human epidermal growth factor 2-positive (HER2+) breast cancer. Patients diagnosed with brain metastases from primary breast cancer, as determined by computed tomography and/or magnetic resonance imaging, at Asan Medical Center from January 1990 to July 2006 were identified and classified into three subtypes: TN, HER2+, and other. The clinical features and outcomes of these three groups were compared. Of the 7,872 patients diagnosed with primary breast cancer, 198 developed brain metastases; of these, 61 patients with unknown estrogen receptor, progesterone receptor, and HER2 status were excluded. Of the remaining 137 patients, 44 (32%) were classified as TN, 69 (50%) as HER2+, and 24 (18%) as other. Clinical parameters, including performance status and previous adjuvant chemotherapy and/or radiotherapy, were well balanced among groups, except that earlier staged tumors (I and II) were more prevalent in the TN than in the HER2+ and other (59 vs. 36 vs. 38%, P = 0.01). At a median follow-up of 99 months, the median times from initial diagnosis to brain metastasis (20 vs. 32 vs. 45 months, P = 0.01) and to first distant metastasis at any site (16 vs. 23 vs. 23 months, P = 0.005) were significantly shorter in TN than in the HER2+ and other. Median overall survival (OS) from primary cancer diagnosis was significantly shorter in the TN than in the HER2+ and other (31 vs. 39 vs. 57 months, P = 0.02), but survival after brain metastasis was similar (5.9 vs. 5.2 vs. 8.8 months, P = 0.31). Compared with other breast cancer phenotypes, TN breast cancer was characterized by earlier brain and other distant metastases and shorter OS, despite a higher proportion of tumors diagnosed at early stages.

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“…EIC was defined as the presence of intraductal components extending both beyond the lesion and within the lesion. Cases were considered positive for ER when strong nuclear staining was observed in at least 10% of the tumour cells tested [30]. Tumour size was measured by a combined macroscopic and microscopic measurement of the greatest diameter of the invasive carcinoma.…”

Section: Pathologymentioning

confidence: 99%

Correlation between mammographic and sonographic findings and prognostic factors in patients with node-negative invasive breast cancer

Shin

Kim²,

Huh³

et al. 2011

BJR

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Objectives: The purpose of this study was to correlate sonographic and mammographic findings with prognostic factors in patients with node-negative invasive breast cancer. Methods: Sonographic and mammographic findings in 710 consecutive patients (age range 21-81 years; mean age 49 years) with 715 node-negative invasive breast cancers were retrospectively evaluated. Pathology reports relating to tumour size, histological grade, lymphovascular invasion (LVI), extensive intraductal component (EIC), oestrogen receptor (ER) status and HER-2/neu status were reviewed and correlated with the imaging findings. Statistical analysis was performed using logistic regression analysis and intraclass correlation coefficient (ICC). Results: On mammography, non-spiculated masses with calcifications were associated with all poor prognostic factors: high histological grade, positive LVI, EIC, HER-2/neu status and negative ER. Other lesions were associated with none of these poor prognostic factors. Hyperdense masses on mammography, the presence of mixed echogenicity, posterior enhancement, calcifications in-or-out of masses and diffusely increased vascularity on sonography were associated with high histological grade and negative ER. Associated calcifications on both mammograms and sonograms were correlated with EIC and HER-2/neu overexpression. The ICC value for the disease extent was 0.60 on mammography and 0.70 on sonography. Conclusion: Several sonographic and mammographic features can have a prognostic value in the subsequent treatment of patients with node-negative invasive breast cancer. Radiologists should pay more attention to masses that are associated with calcifications because on both mammography and sonography associated calcifications were predictors of positive EIC and HER-2/neu overexpression.

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Histopathologic characterization of human breast cancer in correlation with estrogen receptor status.A comparison of immunocytochemical and biochemical analysis

Cited by 77 publications

References 18 publications

17 β -Hydroxysteroid dehydrogenase type 1 and type 2 in human breast carcinoma: a correlation to clinicopathological parameters

17 β -Hydroxysteroid dehydrogenase type 1 and type 2 in human breast carcinoma: a correlation to clinicopathological parameters

Clinical features and course of brain metastases in triple-negative breast cancer: comparison with human epidermal growth factor receptor 2-positive and other type at single institution in Korea

Correlation between mammographic and sonographic findings and prognostic factors in patients with node-negative invasive breast cancer

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