Histopathologic characteristics of scleromyxedema: A study of a series of 34 cases

Rongioletti, Franco; Merlo, Giulia; Carli, Claudio De; Cribier, B.; Metze, Dieter; Calonje, Eduardo; Kempf, Werner; Stefanato, Catherine M.; Marinho, E.; Kanitakis, Jean

doi:10.1016/j.jaad.2015.12.021

Cited by 48 publications

(63 citation statements)

References 16 publications

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“…Histopathological evaluation is important for the diagnosis of scleromyxoedema . The classic triad of mucin deposition, fibroblast proliferation and fibrosis was present in our case .…”

Section: Discussionmentioning

confidence: 99%

“…The classic triad of mucin deposition, fibroblast proliferation and fibrosis was present in our case . Positive alcian blue (pH 2.5) staining was abolished by hyaluronidase pretreatment, confirming dermal mucin deposits to be hyaluronic acid . Trichrome staining confirmed fibrosis, whereas Verhoeff–Van Gieson staining showed slightly reduced elastin fibres .…”

Section: Discussionmentioning

confidence: 99%

“…Positive alcian blue (pH 2.5) staining was abolished by hyaluronidase pretreatment, confirming dermal mucin deposits to be hyaluronic acid . Trichrome staining confirmed fibrosis, whereas Verhoeff–Van Gieson staining showed slightly reduced elastin fibres . Immunophenotyping identified a mild infiltrate of T‐lymphocytes, B‐lymphocytes and macrophages, which is reported in people .…”

Section: Discussionmentioning

confidence: 99%

“…Trichrome staining confirmed fibrosis, whereas Verhoeff–Van Gieson staining showed slightly reduced elastin fibres . Immunophenotyping identified a mild infiltrate of T‐lymphocytes, B‐lymphocytes and macrophages, which is reported in people . A few macrophages, Iba‐1 positive, appeared to be activated, but were insufficient to support the granuloma annulare‐like variant of scleromyxoedema .…”

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Scleromyxoedema in a dog

Laprais

Bizikova

Lashnits

et al. 2017

Veterinary Dermatology

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show abstract

“…Histopathological evaluation is important for the diagnosis of scleromyxoedema . The classic triad of mucin deposition, fibroblast proliferation and fibrosis was present in our case .…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Scleromyxoedema in a dog

Laprais

Bizikova

Lashnits

et al. 2017

Veterinary Dermatology

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show abstract

“…Die für das klassische, nekrobiotische Granuloma anulare typische Palisadenstellung der Histiozyten um Nekrobioseareale sowie die Einwanderung neutrophiler Granulozyten wurden beim interstitiell granulomatösen Muster des Skleromyxödems bislang nicht beschrieben [4][5][6][7] . Liegt neben der interstitiell histiozytären Komponente zusätzlich eine vakuoläre Basalzelldegeneration oder eine Vermehrung eosinophiler Granulozyten vor, ist histologisch eher eine interstitiell histiozytäre Arzneireaktion zu favorisieren.…”

Section: Histologischer Befundunclassified

Skin‐colored papules on the elbows with a granuloma‐annulare‐like histological pattern

Liersch

Rohdenburg²,

Duckheim³

et al. 2018

J Deutsche Derma Gesell

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Cutaneous Mucinoses

Rongioletti

2024

Rook's Textbook of Dermatology

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Cutaneous mucinoses are a heterogeneous group of diseases whose main characteristic is the abnormal excessive deposition of mucin (glycosaminoglycans) in the skin. The aetiopathogenesis of cutaneous mucinoses is unknown, although a few cytokines such as tumour necrosis factor α and β, interleukin 1, interleukin 6, and transforming growth factor β and/or polyclonal immunoglobulins and monoclonal and other unidentified factors in patient serum, may induce pathological stimulation of glycosaminoglycan synthesis. Cutaneous mucinoses are divided into two groups: primary cutaneous mucinoses in which mucin deposition is the main histological feature leading to specific clinical lesions, and secondary mucinoses in which mucin deposition is only an additional histological epiphenomenon. Primary mucinoses can be divided into dermal and follicular mucinoses. The former includes lichen myxoedematosus (papular mucinosis), divided into diffuse/generalised lichen myxoedematosus (also called scleromyxoedema) and the localised form, reticular erythematous mucinosis (REM), scleroedema, mucinosis in thyroid disease, papular and nodular mucinosis in connective tissue diseases, self‐healing (juvenile) cutaneous mucinosis, cutaneous focal mucinosis and digital myxoid cyst. While the follicular mucinoses include Pinkus follicular mucinosis and urticaria‐like follicular mucinosis. Associated disorders include paraproteinaemia (scleromyxoedema, scleroedema), diabetes mellitus (scleroedema), hyperthyroidism (pretibial myxoedema), hypothyroidism (generalised myxoedema), and lupus erythematosus, dermatomyositis or scleroderma (papular and nodular mucinosis in patients with connective tissue). There are no evidence‐based therapies for the main conditions, although some positive results have been obtained with intravenous immunoglobulin in scleromixoedema, antimalarials in REM and phototherapy in scleroedema.

show abstract

Histopathologic characteristics of scleromyxedema: A study of a series of 34 cases

Cited by 48 publications

References 16 publications

Scleromyxoedema in a dog

Scleromyxoedema in a dog

Skin‐colored papules on the elbows with a granuloma‐annulare‐like histological pattern

Cutaneous Mucinoses

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