Histopathologic characteristics of neonatal cutaneous lupus erythematosus: description of five cases and literature review

Peñate, Yeray; Guillermo, N.; Rodríguez, Julio César; Hernández‐Machín, Buenaventura; Montenegro, T.; Afonso, Juan L.; Borrego, Leopoldo

doi:10.1111/j.1600-0560.2008.01136.x

Cited by 48 publications

(35 citation statements)

References 56 publications

(57 reference statements)

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“…The histopathology of the erythematous-desquamative lesions shows vacuolar alterations at the dermoepidermal interface and adnexal structures [30]. Some patients present with urticaria-like lesions that have superficial and deep perivascular and periadnexal lymphocytic infiltrates.…”

Section: Skin Manifestationsmentioning

confidence: 99%

Neonatal Lupus Erythematosus

Nasef

Hafez²,

Bakr³

2014

NCP

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Neonatal lupus is a passively acquired autoimmune disease that occurs in offspring of mothers with anti-SSA/Ro and/or anti-SSB/La antibodies. The primary clinical features are a photosensitive rash that is usually found on the scalp and periorbital areas, congenital heart block with or without cardiomyopathy, cytopenias, disseminated intravascular coagulation, and neonatal cholestasis with or without elevated transaminases. The diagnosis is usually made in utero by detection of a slow fetal heart rate and subsequent fetal echocardiographic confirmation of heart block and/or cardiomyopathy. Prenatal treatment with fluorinated glucocorticoids beginning as soon after detection has favourable outcome for mothers of fetuses with second degree heart block, is of no value for mothers of fetuses with third degree heart block, and controversial for mothers of fetuses with first degree heart block. Prenatal glucocorticoids can be used also in presence of cardiomyopathy associated with neonatal lupus. Hydroxychloroquine has been used in pregnant women who have anti-SSA/Ro antibodies and who have previously given birth to a child with cardiac manifestations. First and second degree block, detected in utero or at birth, can progress to complete heart block. Infants with complete heart block usually require a pacemaker with an excellent prognosis, although development of heart failure may occur.

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Section: Skin Manifestationsmentioning

confidence: 99%

Neonatal Lupus Erythematosus

Nasef

Hafez²,

Bakr³

2014

NCP

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“…However, eosinophilic polymyositis is regarded nowadays as clinical entity [3] and in lupus erythematosus and rheumatoid arthritis mast cells, macrophages and few eosinophils are present in inflamed rheumatoid synovial tissue and sites of cartilage. Such findings are at variance with those in allergic inflammation, in which the presence of eosinophils has been reported to be regulated by specific chemokines and adhesion molecules [4,5]. Therefore an association with Kounis syndrome [6] cannot be excluded.…”

mentioning

confidence: 57%

Coronary artery spasm progressing to acute myocardial infarction in patients with systemic inflammatory disease: A potential association with Kounis syndrome

Almpanis¹,

Kounis²,

Mazarakis³

et al. 2011

International Journal of Cardiology

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“…However, multisystem involvement is less common. [345] Both mother and the child are at an increased risk of developing some rheumatologic or autoimmune disease in future. [3567]…”

Section: Discussionmentioning

confidence: 99%