Histopathologic and prognostic correlations regarding human papillomavirus (HPV) infection in penile squamous cell carcinomas (SCC) considering the novel 2016 WHO classification

Hölters, Sebastian; Khalmurzaev, Oybek; Ueberdiek, Stefan; Loertzer, Philine; Pfuhl, Thorsten; Pryalukhin, Alexey; Hartmann, Anne; Janssen, Martin; Loertzer, Hagen; Wunderlich, Heiko; Hauschild, E.; Bohle, Rainer M.; Smola, Sigrun; Stöckle, M.; Matveev, V.; Junker, Kerstin

doi:10.1016/s1569-9056(17)30771-6

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“…The relationship between papilloma virus infection and inflammation is also well documented 55 . There is evidence, both in human and horse, associating papillomavirus infection with squamous cell carcinomas of the penis 7,15,56 . The relationship between infection and dysplasia (a pre-malignant change) is well-characterised in the case of human cervical cancer, where HPV is found in over 99% of cervical cancers 13 .…”

Section: Inflammation Ecpv2 and Epscc The Association Between Chronmentioning

confidence: 99%

Equine penile squamous cell carcinoma: expression of biomarker proteins and EcPV2

Arthurs

Suárez‐Bonnet

Willis

et al. 2020

Sci Rep

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equine penile squamous cell carcinoma (epScc) is a relatively common cutaneous neoplasm with a poor prognosis. in this study, we aimed to determine the protein expression and colocalisation of FRA1, c-Myc, Cyclin D1, and MMP7 in normal (NT), tumour (T), hyperplastic epidermis and/or squamous papilloma (Hyp/Pap), poorly-differentiated (PDSCC), or well-differentiated (WDSCC) EpSCC using a tissue array approach. further objectives were to correlate protein expression to (i) levels of inflammation, using a convolutional neural network (ii) equine papillomavirus 2 (EcPV2) infection, detected using PCR amplification. We found an increase in expression of FRA1 in EpSCC compared to NT samples. c-Myc expression was higher in Hyp/Pap and WDSCC but not PDSCC whereas MMP7 was reduced in WDSCC compared with NT. There was a significant increase in the global intersection coefficient (GIC) of FRA1 with MMP7, c-Myc, and Cyclin D1 in EpSCC. Conversely, GIC for MMP7 with c-Myc was reduced in EpSCC tissue. Inflammation was positively associated with EcPV2 infection in both NT and EpSCC but not Hyp/Pap. Changes in protein expression could be correlated with EcPV2 for Cyclin D1 and c-Myc. Our results evaluate novel biomarkers of EpSCC and a putative correlation between the expression of biomarkers, EcPV2 infection and inflammation. Equine penile squamous cell carcinoma (EpSCC) is a cutaneous neoplasm with a poor prognosis that often results in euthanasia due to late presentation, treatment difficulties and deterioration. EpSCC are often seen with precancerous pink to yellow plaques and genital papillomas. The lesion is seen mostly at the end of the second and beginning of the third decade of life 1. The term penile intraepithelial neoplasia (PIN) used in humans may also be applied to these lesions. After sarcoids, squamous cell carcinomas are considered the most common equine neoplasm 1-3. Around one tenth of all equine neoplasms are diagnosed in the penis, vulva and ocular adnexa 4,5 of which EpSCC is the most common. Incidence rates of EpSCC, reported more in ponies compared to horses 6 , vary and no specific breed predilection has been ascertained 6. The recorded incidence rates for EpSCCs are between 50-80% of all external genital neoplasms, however one report recorded that EpSCC made up around a fifth of all diagnosed equine cancers in a single UK laboratory over a 29-year period, with the incidence of cutaneous equine tumours also varying by region 6. The possible causes of EpSCC are suggested to be smegma accumulation, ultraviolet light overexposure, chronic irritation and balanoposthitis 7. Chronic inflammation is a known risk factor for cancer development 8. It is also thought that a majority of solid tumours are infiltrated with immune and inflammatory cells 9. The link between human papilloma virus (HPV), cervical cancer 10 and chronic inflammation is known 8. There is evidence to suggest that equine cancers may be initiated, in part, by papillomavirus infection analogous to human cervical and penile cancer 11. These sugge...

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Section: Inflammation Ecpv2 and Epscc The Association Between Chronmentioning

confidence: 99%

Equine penile squamous cell carcinoma: expression of biomarker proteins and EcPV2

Arthurs

Suárez‐Bonnet

Willis

et al. 2020

Sci Rep

View full text Add to dashboard Cite

show abstract

Histopathologic and prognostic correlations regarding human papillomavirus (HPV) infection in penile squamous cell carcinomas (SCC) considering the novel 2016 WHO classification

Cited by 1 publication

References 0 publications

Equine penile squamous cell carcinoma: expression of biomarker proteins and EcPV2

Equine penile squamous cell carcinoma: expression of biomarker proteins and EcPV2

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