Histopathologic and molecular comparative analyses of intravesical Aurora kinase-A inhibitor Alisertib with bacillus Calmette–Guérin on precancerous lesions of bladder in a rat model

Abstract

Although intravesical ALS treatment has similar antiproliferative effects like BCG, ALS + BCG combined treatment led to a best histopathologic and apoptotic response. Consequently, BCG combined with Aurora-A inhibition may provide a new intravesical treatment modality in the prevention of bladder carcinogenesis.

Contrasting Dynamics of Apoptosis and of Cell Cycling in Carcinogenesis

“…The development of Aurora kinases as modeled systems of disruption of the cell cycle dynamics is exemplified by the inclusion of resistance to immune system action and for the emergence of parametric independence in tumor origin, establishment and progression. Bacillus Calmette-Guerin combined with Aurora-A inhibition may constitute a new intravesical modality treatment in preventing bladder carcinogenesis [2]. Aberrant cell cycle regulation of human embryonic stem cells is related to centrosome amplification with enhanced chromosomal instability [3].…”