Histopathologic and immunophenotypic features of cutaneous solid organ transplant‐associated graft‐vs‐host disease: Comparison with acute hematopoietic cell transplant‐associated graft‐vs‐host disease and cutaneous drug eruption
Abstract:Background
Although it is relatively common after hematopoietic cell transplant (HCT), graft‐vs‐host disease (GVHD) is a rare complication following solid organ transplantation (SOT).
Methods
This study evaluated skin biopsy specimens from five cases of SOT GVHD, 15 cases of HCT GVHD, and 15 cases of cutaneous drug eruption. Immunohistochemical staining for CD3, CD4, CD8, T‐bet, and GATA‐3 was performed to examine the density and immune phenotype of skin‐infiltrating lymphocytes.
Results
Similar to HCT GVHD, t… Show more
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