Histopathologic and Immunohistopathologic Features of Subretinal Fibrosis and Uveitis Syndrome

Kim, Myung K.; Chan, Chi-C.; Belfort, Rubens; Farah, Michel Eid; Burnier, M.; Nussenblatt, Robert B.; Kuwabara, Toichiro; Palestine, Alan G.

doi:10.1016/0002-9394(87)90287-x

Cited by 47 publications

(21 citation statements)

References 23 publications

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“…Retinal complications have not been reported except for its vasculitis [8][9][10]. In this report, we present two patients with rheumatoid arthritis and renal dysfunction who developed progressive subretinal fibrosis, similar to the clinical entity designated as 'multifocal choroiditis associated with progressive subretinal fibrosis' by Cantrill and Folk [11] or as 'subretinal fibrosis and uveitis syndrome' by Palestine et al [12,13] and Kim et al [14], together with several other authors [15][16][17][18][19][20][21][22].…”

Section: Introductionmentioning

confidence: 80%

Progressive Subretinal Fibrosis in Patients with Rheumatoid Arthritis and Renal Dysfunction

Matsuo

1998

Ophthalmologica

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We present two patients (56-year-old and 71-year-old women) who developed subretinal fibrosis in parallel with exacerbation of rheumatoid arthritis and deteriorated renal function. The first patient developed subretinal fibrosis in the right eye, coupled with multifocal choroiditis and serous retinal detachment in both eyes, in the course of rapidly progressive glomerulonephritis complicated with rheumatoid arthritis. Antineutrophil cytoplasmic antibody was positive in a perinuclear pattern (pANCA) and the increased dose of prednisolone to 40 mg/day resulted in subsidence of the subretinal inflammation. The second patient developed subretinal fibrosis in the left eye with mottled retinal pigment epithelium of both eyes, in the course of rheumatoid arthritis and stable chronic renal failure. Although the manifestations of subretinal fibrosis and concurrent renal dysfunction were different between these two patients, subretinal fibrosis might be noted as a complication of rheumatoid arthritis and renal dysfunction.

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Section: Introductionmentioning

confidence: 80%

Progressive Subretinal Fibrosis in Patients with Rheumatoid Arthritis and Renal Dysfunction

Matsuo

1998

Ophthalmologica

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“…CNV is not common and is diffi cult to diff erentiate from fi brosis. 31 Laboratory evaluation is typically unrewarding. 30 The diff erential diagnosis of SFU is similar to that of MFC and PIC and includes conditions producing panuveitis.…”

Section: Sub-retinal Fibrosis and Uveitis Syndromementioning

confidence: 99%

“…Auto -immune mechanisms have been implicated with the demonstration of local antibodies & B lymphocytes 31 , plasma cells , and subretinal fi brotic tissues with islands of RPE and Muller cells in histopathologic specimens. The disease course is marked by chronic recurrent infl ammation and the visual prognosis is guarded.…”

Section: Sub-retinal Fibrosis and Uveitis Syndromementioning

confidence: 99%

White Dot Syndromes

Biswas¹

2015

DJO

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“…e coróide, localizadas no pólo posterior, que coalescem em semanas evoluindo para extensas áreas de cicatrizes sub-retinianas. A histopatologia revela espesso tecido fibroso subretiniano e infiltrado granulomatoso linfocitário na coróide (6) . O prognósti-co visual destes pacientes é reservado e a resposta ao tratamento com altas doses de corticosteróides é limitada.…”

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