Histopathologic and Clinical Features of Vesical Diverticula

Kong, Max Xiangtian; Zhao, Xueqiang; Kheterpal, Emil; Lee, Peng; Taneja, Samir S.; Lepor, Herbert; Melamed, Jonathan; Deng, Fang

doi:10.1016/j.urology.2013.02.015

Cited by 31 publications

(21 citation statements)

References 10 publications

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“…Epithelial neoplasms have been reported in up to 14% of bladder diverticula, composing approximately 1% of bladder neoplasms [104][105][106]. Based on the unique clinical scenario and anatomy of diverticula, it is an important topic that was not covered in the prior edition.…”

Section: Tumours Arising In a Bladder Diverticulummentioning

confidence: 99%

The 2016 WHO Classification of Tumours of the Urinary System and Male Genital Organs—Part B: Prostate and Bladder Tumours

et al. 2016

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It has been 12 yr since the publication of the last World Health Organization (WHO) classification of tumours of the prostate and bladder. During this time, significant new knowledge has been generated about the pathology and genetics of these tumours. Intraductal carcinoma of the prostate is a newly recognized entity in the 2016 WHO classification. In most cases, it represents intraductal spread of aggressive prostatic carcinoma and should be separated from high-grade prostatic intraepithelial neoplasia. New acinar adenocarcinoma variants are microcystic adenocarcinoma and pleomorphic giant cell adenocarcinoma. Modifications to the Gleason grading system are incorporated into the 2016 WHO section on grading of prostate cancer, and it is recommended that the percentage of pattern 4 should be reported for Gleason score 7. The new WHO classification further recommends the recently developed prostate cancer grade grouping with five grade groups. For bladder cancer, the 2016 WHO classification continues to recommend the 1997 International Society of Urological Pathology grading classification. Newly described or better defined noninvasive urothelial lesions include urothelial dysplasia and urothelial proliferation of uncertain malignant potential, which is frequently identified in patients with a prior history of urothelial carcinoma. Invasive urothelial carcinoma with divergent differentiation refers to tumours with some percentage of "usual type" urothelial carcinoma combined with other morphologies. Pathologists should mention the percentage of divergent histologies in the pathology report. PATIENT SUMMARY Intraductal carcinoma of the prostate is a newly recognized entity in the 2016 World Health Organization classification. Better defined noninvasive urothelial lesions include urothelial dysplasia and urothelial proliferation of uncertain malignant potential. v a i l a b l e a t w w w . s c i e n c e d i r e c t . c o m j AbstractIt has been 12 yr since the publication of the last World Health Organization (WHO) classification of tumours of the prostate and bladder. During this time, significant new knowledge has been generated about the pathology and genetics of these tumours.

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Section: Tumours Arising In a Bladder Diverticulummentioning

confidence: 99%

The 2016 WHO Classification of Tumours of the Urinary System and Male Genital Organs—Part B: Prostate and Bladder Tumours

et al. 2016

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“…Tumors involving peridiverticular soft tissue are often associated with increased risk of local recurrence and progression, including metastasis. [57][58][59][60][61] Perivesical lymph nodes were added as a primary drainage site for bladder urothelial carcinoma as involvement correlates with a worse prognosis (Table 4). 62,63 Therefore, pathologic evaluation of the perivesical soft tissue for lymph nodes are prudent.…”

Section: Updates In Bladder and Urethral Cancer Staging Updates In Blmentioning

confidence: 99%

Updates in Staging and Reporting of Genitourinary Malignancies

Cornejo

Rice-Stitt

2020

Archives of Pathology &Amp; Laboratory Medicine

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Context.— The 8th edition of the American Joint Committee on Cancer (AJCC) staging manual changed the tumor, node, metastasis (TNM) classification systems of genitourinary malignancies in 2017. However, some of the changes appear not well appreciated or recognized by practicing pathologists. Objective.— To review the major changes compared with the 7th edition in cancers of the prostate, penis, testis, bladder, urethra, renal pelvis/ureter, and kidney and discuss the challenges that pathologists may encounter. Data Sources.— Peer-reviewed publications and the 8th and 7th editions of the AJCC Cancer Staging Manual. Conclusions.— This article summarizes the updated staging of genitourinary malignancies, specifically highlighting changes from the 7th edition that are relevant to the pathologic staging system. Pathologists should be aware of the updates made in hopes of providing clarification and the remaining diagnostic challenges associated with these changes.

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“…Most bladder diverticula are small and asymptomatic. A subset of these lesions, however, may be complicated with inflammation, calculus, infection and malignancy [ 2 , 3 ].…”

Section: Introductionmentioning

confidence: 99%

“…Due to its rarity, intradiverticular carcinoma remains infrequently encountered in general practice. As result, the histopathologic features and clinical outcomes of intradiverticular bladder carcinoma are not well investigated, with only three studies of notable size in the current literature, each including less than 40 patients [ 2 , 3 , 7 , 8 ]. While absence of muscularis propria layer may in theory predispose intradiverticular tumors to a greater risk for bladder wall infiltration and possibly spreading into adjacent organs, the aggressiveness of these tumors and their clinical outcomes remain poorly characterized.…”

Section: Introductionmentioning

confidence: 99%

Clinicopathologic characterization of intradiverticular carcinoma of urinary bladder - a study of 22 cases from a single cancer center

et al. 2014

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BackgroundTo examine histopathologic features and clinical outcomes of intradiverticular bladder carcinomas.MethodsTwenty-two consecutive patients with intradiverticular bladder carcinoma treated with either endoscopic transurethral resection or partial or radical cystectomy at a single institution between years of 1995 to 2011. Clinicopathologic characteristics and oncologic outcomes of patients were retrospectively analyzed, including tissue histology re-review by genitourinary pathologists.ResultsHistologically, 9 cases (41%) were non-invasive papillary urothelial carcinoma, 13 cases (59%) were invasive urothelial carcinoma, including three cases of small cell carcinoma. Final pathology revealed synchronous extradiverticular urothelial carcinomas in 6 out of 9 cases (67%) of non-invasive and 2 out of 10 cases (20%) invasive intradiverticular urothelial carcinoma, respectively. More than half of cases (13/22, 59%) showed a distinctive hypertrophic layer of muscularis mucosae. There was no statistical difference in disease free survival or overall survival between non-invasive and invasive tumors within approximately 3 years of follow up (mean 38 months, median 32 months). While stage T3 patients generally did poorly, oncologic outcomes for stage T1 patients were no different than those of stage Ta.ConclusionIntradiverticular carcinomas are often associated with a hypertrophic layer of muscularis mucosae that can potentially confound tumor staging. Non-invasive intradiverticular urothelial carcinomas are more likely to have coexisting synchronous extradiverticular lesions. The absence of a muscularis propria layer may not necessarily predispose T1 tumors to more aggressive disease.Virtual SlidesThe virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/13000_2014_222

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Histopathologic and Clinical Features of Vesical Diverticula

Cited by 31 publications

References 10 publications

The 2016 WHO Classification of Tumours of the Urinary System and Male Genital Organs—Part B: Prostate and Bladder Tumours

The 2016 WHO Classification of Tumours of the Urinary System and Male Genital Organs—Part B: Prostate and Bladder Tumours

Updates in Staging and Reporting of Genitourinary Malignancies

Clinicopathologic characterization of intradiverticular carcinoma of urinary bladder - a study of 22 cases from a single cancer center

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