Histones are exosome membrane proteins regulated by cell stress
Birendra Singh,
Marcus Fredriksson Sundbom,
Uma Muthukrishnan
et al.
Abstract:Histones are conserved nuclear proteins that function in the regulation of chromatin structure and gene expression. Interestingly, extracellular histones populate biofluids from healthy individuals and when elevated may contribute to various acute and chronic diseases. It is unknown if histones are secreted via a controlled pathway, or merely released from damaged or dying cells. We analysed cell culture models under normal and stressed conditions to identify pathways of histone secretion. We report that core … Show more
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