2020
DOI: 10.1016/j.bbrc.2020.09.108
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Histone methylation status of H3K4me3 and H3K9me3 under methionine restriction is unstable in methionine-addicted cancer cells, but stable in normal cells

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Cited by 48 publications
(79 citation statements)
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“…These results indicated that malignancy was decreased in methionine-independent revertants compared to parental methionine-addicted cancer cells, due to the decrease in histone H3 lysine methylation. The results of the present study and our previous study (14) indicate that overmethylation of lysines in histone H3 is necessary for both methionine addiction of cancer cells and their malignancy.…”
Section: Resultssupporting
confidence: 80%
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“…These results indicated that malignancy was decreased in methionine-independent revertants compared to parental methionine-addicted cancer cells, due to the decrease in histone H3 lysine methylation. The results of the present study and our previous study (14) indicate that overmethylation of lysines in histone H3 is necessary for both methionine addiction of cancer cells and their malignancy.…”
Section: Resultssupporting
confidence: 80%
“…Mentch et al showed that tri-methyl histone H3 was unstable in cancer cells under MR but did not examine the stability of tri-methyl histone H3 in normal cells under MR (21). Our recent previous study also demonstrated that histone H3K4me3 and H3K9me3 were unstable in cancer cells under MR; and we showed for the first time H3K4me3 and H3K9me3 were stable in normal cells under MR (14), which explains why cancer cells arrest under MR and normal cells do not. And most importantly, the present study shows that pan-histone H3 lysine, H3K4me3 and H3K9me3 are not over methylated in normal cells or in methionine-independent revertants that have decreased malignancy and lost methionine addiction, and can proliferate under MR.…”
Section: Discussionsupporting
confidence: 62%
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