Histone macroH2A isoforms predict the risk of lung cancer recurrence

Sporn, Judith C.; Kustatscher, Georg; Hothorn, Torsten; Collado, Manuel; Serrano, Manuel; Muley, Thomas; Schnabel, Philipp A.; Ladurner, Andreas G.

doi:10.1038/onc.2009.26

Cited by 163 publications

(194 citation statements)

References 18 publications

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“…In this context, it is interesting to point out that melanoma cells are dedifferentiated cells that reactivate embryonic signaling pathways [54]. Others could point out functional differences between macroH2A1 splice variants in different types of cancer [55,56]. Ongoing and future studies are likely to reveal the importance, the regulation and the molecular function of macroH2A-containing epigenetic mechanisms in a larger number of physiological and pathological processes.…”

Section: Future Perspectivementioning

confidence: 99%

MacroH2A in Stem Cells: A Story Beyond Gene Repression

et al. 2012

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The importance of epigenetic mechanisms is most clearly illustrated during early development when a totipotent cell goes through multiple cell fate transitions to form the many different cell types and tissues that constitute the embryo and the adult. The exchange of a canonical H2A histone for the ‘repressive’ macroH2A variant is one of the most striking epigenetic chromatin alterations that can occur at the level of the nucleosome. Here, we discuss recent data on macroH2A in zebrafish and mouse embryos, in embryonic and adult stem cells and also in nuclear reprogramming. We highlight the role of macroH2A in the establishment and maintenance of differentiated states and we discuss its still poorly recognized function in transcriptional activation.

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Section: Future Perspectivementioning

confidence: 99%

MacroH2A in Stem Cells: A Story Beyond Gene Repression

et al. 2012

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“…In the present study, the artificial altering of macroH2A expression was performed by the interference and overex- (25)(26)(27)(28)(29)(30). In these cancer types, the expression levels of macroH2A decreased significantly in tumor tissues compared with normal tissues.…”

Section: Discussionmentioning

confidence: 99%

MacroH2A suppresses the proliferation of the B16 melanoma cell line

Lei

Long

2014

Molecular Medicine Reports

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Abstract. MacroH2A is the most frequently altered histone, which participates in cancer progression. Increasing evidence demonstrates that cancer progression could be regulated by macroH2A by affecting the cell cycle. In the present study, it was demonstrated that macroH2A suppresses melanoma cell progression and the molecular mechanisms underlying this process were examined. The interference and overexpression vectors of macroH2A were constructed and then transferred into B16 melanoma cells and, following transfection, were analyzed by quantitative polymerase chain reaction (PCR), western blot analysis and immunofluorescence assays. Apoptosis and the cell cycle stage among all the treatment groups were detected. Then, cyclin D1, cyclin D3, cyclin-dependent protein kinase (CDK) 4, CDK6 and CDK8 expression was detected in order to elucidate the effects of macroH2A on cell cycle-related genes. The results demonstrated that the overexpression of macroH2A suppressed melanoma cell progression and arrested the cells in the G2/M stage. Furthermore, macroH2A inhibits cyclin D1, cyclin D2, CDK6 and CDK8 expression in B16 melanoma cells. In conclusion, the results demonstrated that macroH2A, a critical component of chromatin, suppresses the development of melanoma (which results from a disordered cell cycle) through regulating cyclin D1, cyclin D3 and CDK6 genes.

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“…The gene for lncRNA RP11-672F9.1, upregulated in H2, was co-expressed with 10 mRNAs. One of these mRNAs, H2AFY2, is located near lncRNA RP11-672F9.1, which is reported to predict lung cancer recurrence (Sporn et al, 2009). The gene for lncRNA CR613944, downregulated in H2, was co-expressed with 22 mRNAs, 12 of which were related to cell adhesion, cell migration, and various types of cancer.…”

Section: Discussionmentioning

confidence: 99%

Long Non-coding RNAs are Differentially Expressed in Hepatocellular Carcinoma Cell Lines with Differing Metastatic Potential

Fang

Sun²,

Chen³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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(Talmadge and Fidler, 2010). A salient feature of metastasis is the ability of cancer cells to colonize specific organ sites (Hanahan and Weinberg, 2011). For instance, HCC cells metastasize to the lung more frequently than the lymph nodes. It is well recognized that the probability of metastatic seeding and growth is determined by both intrinsic genetic properties of the cancer cells involved and characteristics of the stromal microenvironment that surrounds them (Lu and Kang, 2007;Nguyen et al., 2009). Functional genomic analysis of HCC cell lines with different organ-specific metastatic potential may provide new opportunities for identifying diagnostic biomarkers and developing therapies to combat HCC metastasis.Large-scale genomic studies have demonstrated that the mammalian genome encodes many thousands Ting-Ting Fang et al

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Histone macroH2A isoforms predict the risk of lung cancer recurrence

Cited by 163 publications

References 18 publications

MacroH2A in Stem Cells: A Story Beyond Gene Repression

MacroH2A in Stem Cells: A Story Beyond Gene Repression

MacroH2A suppresses the proliferation of the B16 melanoma cell line

Long Non-coding RNAs are Differentially Expressed in Hepatocellular Carcinoma Cell Lines with Differing Metastatic Potential

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