Abstract:Histone deacetylases (HDAC) are enzymes that regulate biological activity through removal of acetyl groups from histones and non-histone proteins. A few HDAC inhibitors have been approved for use as anti-cancer agents, but their clinical uptake so far has been limited, presumably due to their adverse effect profiles. Consequently, a new generation of HDAC inhibitors has emerged with improved chemistry and pharmacological properties, optimised through mechanism of action and precision medicine strategies. In th… Show more
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